Depressants

Long-term benzodiazepine use is less likely when shorter courses, a single medication or short-acting agents are prescribed, per cohort study of more than 1.8 million Canadian adults which could inform prescribing practices

A cohort study of over 1.8 million Canadian adults found that shorter prescription courses, single medication, and short-acting agents are associated with lower rates of long-term benzodiazepine use. This study provides valuable insights for informing prescribing practices to reduce reliance on these medications.

SourcePLOS·JournalPLOS Medicine·TypeObservational study·DateJun 18, 2026

Antidepressant unable to prevent chemotherapy-associated nerve damage

A randomized trial found that duloxetine does not prevent painful neuropathy caused by oxaliplatin-based chemotherapy in patients with stage II or III colorectal cancer. The study suggests that duloxetine should only be used for managing existing neuropathy, not prevention.

SourceAlliance for Clinical Trials in Oncology·JournalJCO Oncology Advances·TypeRandomized controlled/clinical trial·DateApr 8, 2026

Rigol DP832 Triple-Output Bench Power Supply

Rigol DP832 Triple-Output Bench Power Supply powers sensors, microcontrollers, and test circuits with programmable rails and stable outputs.

New ‘designer drugs’ pose growing threat to road safety in the US

A new study found that new psychoactive substances (NPS) are a significant concern in roadway crashes in California. NPS, also known as ‘designer drugs’, were detected in the blood of 17 patients, with most frequent being designer benzodiazepines and fentanyl analogs.

SourceFrontiers·JournalFrontiers in Toxicology·TypeObservational study·DateJun 25, 2025

Initial prescriptions of sedatives among older stroke survivors may include too many pills

A new study found that initial prescriptions of benzodiazepines for older stroke survivors often include excessive doses, posing a risk of dependence, falls, and other harmful effects. Guidelines recommend avoiding benzodiazepine prescriptions if possible, but some cases may require limited use under close monitoring.

SourceAmerican Heart Association·JournalStroke·DateOct 17, 2024

4TEEN4's first-in-class therapeutic antibody Procizumab restores heart function in life-threatening cardiac depression induced by sepsis

The study data show that Procizumab promptly restored cardiac dysfunction in a preclinical sepsis model by inhibiting the cardiac depressant factor DPP3. The administration of Procizumab improved heart function by increasing cardiac output, stroke volume, and left ventricular shortening fraction.

Source4TEEN4 Pharmaceuticals GmbH·JournalPLOS ONE·DateSep 16, 2020