Articles tagged with Drug Safety
Researchers at the University of Pennsylvania School of Medicine have developed a new approach to bone marrow transplantation that prevents graft-versus-host disease by inactivating antigen-presenting cells. This technique targets T cell stimulation, reducing immune system suppression and potentially improving cancer treatment outcomes.
A human factors approach to interface design significantly reduces errors in patient-controlled analgesia. The redesigned device shows a 55% reduction in errors, an 18% improvement in performance time, and a strong preference among nurses.
The safety of new high blood pressure drugs is being questioned due to insufficient data. Centrally acting antihypertensives have been found to target brainstem receptors that orchestrate blood vessel dilation, but concerns remain over their long-term effectiveness in reducing heart attacks, strokes, and deaths.
A unique gel formulation of diazepam has been found to reduce the severity of acute repetitive seizure episodes in both children and adults. The treatment, administered through a Quick-Dose delivery system, protects patients from seizure recurrence and enables caregivers to administer treatment privately.
Three experts recommend establishing a national office of drug safety to track and reduce prescription drug-related injuries, which could be the fourth-leading cause of death in the US. The proposed office should develop reliable estimates of deaths and serious injuries from prescription drugs.
Researchers at the Brain Attack Team (BAT) are developing Tele-BAT, a system that enables remote evaluation of stroke patients via video, cellular telephone, and computer technology. This allows for faster diagnosis and treatment, as it can provide valuable information to emergency rooms before patients arrive.
A nationwide review of managed-care companies' gatekeeping practices found nearly one-third of patients denied emergency medical care suffered adverse outcomes. The study highlights the need for in-person medical assessments, as telephone gatekeeping failed to reliably distinguish between safe and unsafe cases.
Researchers have found a potential link between calcium channel blockers and brain damage, as well as impaired memory. The study analyzed data from the Cardiovascular Health Study and found that participants taking these medications had more evidence of white matter hyperintensity and lower scores on mental tests.
A meta-analysis of 98 studies found that sustained-release and extended-release formulations of nifedipine are safe when used in combination with diuretics or beta blockers. However, patients taking short-acting nifedipine were more likely to experience adverse side effects.
A University of Pittsburgh study has successfully weaned 41 adults and children off immunosuppressive drugs for extended periods, with 25 patients remaining drug-free after seven years or more. Close surveillance is crucial to manage rejection and prevent graft loss, says Dr. Reyes.
The FDA has approved fexofenadine, a new antihistamine that effectively relieves seasonal allergy symptoms without the risk of fatal heart conditions. Developed by Georgetown pharmacologist Raymond Woosley, fexofenadine was discovered through research on Seldane's cardiac side effects.
Daily performance testing is suitable for immediate determination of relevant psychomotor impairment at the start of work. However, managers must remain aware of test limitations associated with job requirements, such as decision-making skills required for driving a truck safely.