Articles tagged with Drug Safety
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
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Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
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A recent study found that a sepsis drug, DAA, can significantly reduce hospital care and mortality rates among older patients. The study, which followed 386 patients over two years, showed that the drug improved survival rates and reduced the need for intensive care.
The use of generic drugs led to a slowdown in prescription drug spending during the first quarter, with a 3.2% reduction in dollar outlay. Physicians responded positively to safety warnings and modified patient therapy as a result, with 38% changing or modifying their treatment.
Researchers at Johns Hopkins Medicine have made a breakthrough in treating children with chronic hepatitis C (CHC). A multi-center study found that peginterferon alfa-2a was effective in reducing the virus in 43% of pediatric patients. The new treatment approach offers hope to both affected children and their worried families.
A new antibiotic, fosmidomycin, has been shown to be effective against the Plasmodium falciparum parasite, with rapid parasite elimination and fever reduction. Cure rates after two weeks were 89%, 88%, and 60% for treatment durations of 5, 4, and 3 days, respectively.
The study found that COX-2 inhibitors led to a substantial increase in NSAID prescriptions and expenditures among elderly patients in Ontario. The listing of these medications had an immediate impact, accounting for 48% of prescriptions and 66% of expenditures for NSAIDs.
A randomized trial of simvastatin in 173 children with heterozygous familial hypercholesterolemia found significant reductions in all cholesterol measures. The drug was well-tolerated and did not affect growth or pubertal development, making it a safe option for treating inherited high cholesterol in children.
Researchers at Stanford University Medical Center have confirmed that pill-splitting can be a safe and viable cost-saving strategy for certain medications. By splitting higher-strength pills to achieve desired dosages, patients can reduce medication costs by up to 50%. However, the practice must be implemented with careful controls and...
A new study found sertraline to be both safe and effective in treating depression among hospitalized heart patients. The trial showed a 23% reduction in life-threatening cardiovascular events, although not statistically significant, indicating potential benefits of sertraline for this population.
A study by Georgetown University researchers found that initially recommended drug dosages are often too high, which can lead to unnecessary overdosing. This discrepancy has significant implications for patient safety and healthcare costs. Further research is needed to address the issue of dose-selection in drug development.
A study found that UK family doctors under-report suspected adverse drug reactions, with only 9% of events reported to the CSM. However, serious events were five times more likely to be reported than non-serious ones.
The Suncoast Developmental Center will analyze data on patient falls and medication errors among elderly patients to improve patient safety. Researchers aim to identify checks and balances in the healthcare system to prevent or reduce mistakes.
A meta-analysis of 27 trials involving over 136,000 people found that lowering high blood pressure is the most important effect of all drug treatments, with little difference between various drugs used. The study's results support the importance of detecting and treating raised blood pressure to prevent cardiovascular disease.
The study recommends that physicians specifically ask patients about herbal medication use before surgery, as many patients fail to disclose their use. Herbal medications can affect heart rate, blood clotting, and immune function, making it essential for patients to stop taking them before surgery.
A Yale University study found no correlation between household hazards and elderly falls, contradicting common wisdom. Instead, researchers recommend targeting proven methods like increasing muscle strength, improving gait and balance, and proper medication management.
Defibrillator availability for home use could save thousands of lives, says Dr. Mickey Eisenberg. Despite high costs, he suggests AEDs could become more affordable and accessible with proper labeling and training.
A study of homeless people in Toronto shelters found that 72% had difficulties managing their diabetes due to factors like shelter diet and medication logistics. The authors recommend improving care by establishing secure areas for insulin administration and assessing shelter meals.
The National Toxicology Program (NTP) will review testing recommendations for future studies on DNA-based therapies, dietary supplements, and occupational chemicals. The agenda includes discussion of DNA-derived vaccines, gene therapies, and radio frequency radiation emissions from cellular phones.
The Clinical Advantage program aims to reduce the gap between effective treatments and conventional care for heart attack patients. By implementing evidence-based techniques, hospitals hope to improve assessment, management, and discharge planning, resulting in better patient outcomes.
The National Patient Safety Foundation announced four grant winners in its 1999 Research Awards, supporting projects aimed at improving patient safety. The grants, totaling up to $100,000, will fund studies on various aspects of patient safety, including cardiac surgery and pediatric sedation.
Researchers at Vion Pharmaceuticals have developed a novel gene-based anti-cancer drug delivery system using Salmonella bacteria. The TAPET technology has shown complete tumor regression in mice and high safety profiles, with potential applications for treating various types of cancer.
The National Patient Safety Foundation has launched an initiative to reduce medication error risk, focusing on redesigning practices for safe medication use. Key findings include the need for broad cooperation across the healthcare system to improve pharmaceutical safety.
A new botulinum toxin type B medication has shown significant improvements in pain, disability, and disease severity in cervical dystonia patients. The treatment's benefits lasted for 12-16 weeks with no serious adverse side effects reported.
The US dietary supplement market is projected to reach $14 billion in 2000, with most supplements being unregulated. Dr. Steven H. Zeisel proposes creating a special 'nutraceuticals' category for regulated supplements that deliver concentrated forms of bioactive agents beyond food levels.
Researchers at the University of Pennsylvania School of Medicine have developed a new approach to bone marrow transplantation that prevents graft-versus-host disease by inactivating antigen-presenting cells. This technique targets T cell stimulation, reducing immune system suppression and potentially improving cancer treatment outcomes.
A human factors approach to interface design significantly reduces errors in patient-controlled analgesia. The redesigned device shows a 55% reduction in errors, an 18% improvement in performance time, and a strong preference among nurses.
The safety of new high blood pressure drugs is being questioned due to insufficient data. Centrally acting antihypertensives have been found to target brainstem receptors that orchestrate blood vessel dilation, but concerns remain over their long-term effectiveness in reducing heart attacks, strokes, and deaths.
A unique gel formulation of diazepam has been found to reduce the severity of acute repetitive seizure episodes in both children and adults. The treatment, administered through a Quick-Dose delivery system, protects patients from seizure recurrence and enables caregivers to administer treatment privately.
Three experts recommend establishing a national office of drug safety to track and reduce prescription drug-related injuries, which could be the fourth-leading cause of death in the US. The proposed office should develop reliable estimates of deaths and serious injuries from prescription drugs.
Researchers at the Brain Attack Team (BAT) are developing Tele-BAT, a system that enables remote evaluation of stroke patients via video, cellular telephone, and computer technology. This allows for faster diagnosis and treatment, as it can provide valuable information to emergency rooms before patients arrive.
A nationwide review of managed-care companies' gatekeeping practices found nearly one-third of patients denied emergency medical care suffered adverse outcomes. The study highlights the need for in-person medical assessments, as telephone gatekeeping failed to reliably distinguish between safe and unsafe cases.
Researchers have found a potential link between calcium channel blockers and brain damage, as well as impaired memory. The study analyzed data from the Cardiovascular Health Study and found that participants taking these medications had more evidence of white matter hyperintensity and lower scores on mental tests.
A meta-analysis of 98 studies found that sustained-release and extended-release formulations of nifedipine are safe when used in combination with diuretics or beta blockers. However, patients taking short-acting nifedipine were more likely to experience adverse side effects.
A University of Pittsburgh study has successfully weaned 41 adults and children off immunosuppressive drugs for extended periods, with 25 patients remaining drug-free after seven years or more. Close surveillance is crucial to manage rejection and prevent graft loss, says Dr. Reyes.
The FDA has approved fexofenadine, a new antihistamine that effectively relieves seasonal allergy symptoms without the risk of fatal heart conditions. Developed by Georgetown pharmacologist Raymond Woosley, fexofenadine was discovered through research on Seldane's cardiac side effects.
Daily performance testing is suitable for immediate determination of relevant psychomotor impairment at the start of work. However, managers must remain aware of test limitations associated with job requirements, such as decision-making skills required for driving a truck safely.