Articles tagged with Translational Research
The summit brought together endocrine leaders to identify opportunities to work closely together on increasing the visibility of endocrine health in policy decisions. Early findings from a workforce survey revealed challenges including long patient waiting times and retention concerns among early-career clinicians.
The Cure Innovation Index ranks top US biomedical institutions based on their ability to translate scientific discoveries into real-world healthcare solutions. The index identifies key factors such as commercialization infrastructure, industry engagement, and entrepreneurial culture that enable translational success.
A new targeted therapy has shown strong results in preclinical studies against aggressive childhood and adult cancers, eliminating tumours and stopping cancer spread. The therapy targets the IL1RAP protein, which is found on cancer cells but largely absent from normal tissues, allowing for precise delivery of treatment.
A study mapped early molecular and cellular changes in the jaw joint that may trigger temporomandibular joint osteoarthritis. The research found structural and molecular changes in joint tissues, including inflammation, fibrosis, and metabolic shifts. Single-cell sequencing revealed diverse cell populations interacting within the synov...
Lindsay Squeglia, Ph.D. of the Medical University of South Carolina received the 2026 ACTS Award for Supporting an Excellent Translational Science Workforce. She is a leading figure in substance use prevention and adolescent brain development research.
The Stem Cell Report podcast has marked five years of exploration in stem cell research, capturing significant progress in human development, disease, and regenerative medicine. The anniversary episode reunites past guests to discuss the field's evolution, highlighting advances in therapies, organoid systems, and global standards.
Scientists at the University of Virginia Health System have developed a suite of AI-powered tools, called YuelDesign, YuelPocket and YuelBond, to transform how new drugs are created. These tools can design drug molecules tailored to fit their protein targets exactly, even accounting for protein flexibility.
The San Antonio Breast Cancer Symposium generated nearly $40 million in economic impact and drew over 11,000 attendees from 104 countries. The symposium also produced $1.5 million in local tax revenue and supported more than 6,800 jobs.
The Accelerating Cancer Cures Research Symposium brings together Damon Runyon scientists and industry partners to foster communication and collaboration. The symposium features updates on research aimed at developing more precise targeted therapies for cancer treatment.
Researchers at Memorial Sloan Kettering Cancer Center discovered that skin stem cells possess a remarkable form of inflammatory memory that can last over a year. This finding has implications for understanding how repeated inflammation affects skin aging and disease susceptibility. The study used MSK-IMPACT, a tumor sequencing test, to...
The BiliSeq test detected approximately 82% of bile duct cancers, compared to 44% with pathology alone, and increased cancer detection to nearly 90% when combined with pathology. This improved accuracy enables physicians to provide more personalized medicine and treatment options for patients.
The University of Missouri is honoring three distinguished faculty members as 2025 AAAS Fellows. Paul de Figueiredo is being recognized for his contributions to microbiology, while Roman Ganta advances research on tick-borne diseases. Wesley Warren's expertise in genome-scale data analysis has reshaped research across multiple fields.
The BrainHealth Network connects researchers across the country to understand brain health improvement through advanced MRI imaging and data analysis. The network leverages a comprehensive multimodal brain imaging dataset, including a longitudinal study of 100,000 healthy participants over 10 years.
A multi-phase clinical study will examine dosing, safety and long-term effects of rapamycin in older adults to guide future research on extending health span. Researchers aim to establish evidence-based guidance for the drug's use and move beyond speculation.
A drug already in clinical trials for hepatitis C has been found to also prevent hepatitis E virus replication, offering new hope for a treatment option. The discovery was made using a library of nucleotide/nucleoside analogues and preclinical models.
The Terasaki Institute for Biomedical Innovation and UCLA Technology Development Group will co-curate an Advanced Organ and Tissue Repair (AToR) session at LABEST, featuring leading experts in regenerative medicine. The session aims to accelerate the translation of breakthrough technologies into real-world clinical solutions.
Dr. Gobbi challenges the global drug-development system, stating that promising treatments for mental illness are failing to reach patients due to venture capital and profit motives. Her research focuses on cannabis, melatonin, and psychedelics, with a goal of improving public-health decisions and treatment outcomes.
The NRG-LU005 trial found that immunotherapy atezolizumab did not improve survival for patients with limited-stage small cell lung cancer when added to chemoradiation. Twice-daily radiation therapy, however, was associated with improved survival in this population.
The Alliance trial explores the combination of zanubrutinib and sonrotoclax for CLL treatment, aiming to send cancer into remission and allow patients to stop treatment earlier. The study has the potential to be life-changing for patients and their families, reducing the burden of ongoing therapy and improving quality of life.
Severe COVID-19 and influenza infections can prime the lungs for cancer development, according to new research. Vaccination, however, largely prevents these changes, suggesting a reduced risk of lung cancer.
The partnership aims to accelerate biomedical innovation through joint research programs, faculty collaboration, and expanded student training opportunities. Researchers will have access to shared laboratory infrastructure, reciprocal faculty affiliations, and joint grant proposals.
The Alliance for Clinical Trials in Oncology is spotlighting new trials for colorectal cancer in March, focusing on early detection methods and treatments for treatment delays and loss of appetite. The trials aim to improve patient outcomes, with several enrolling patients with newly diagnosed colon or rectal cancer.
The Greaux Healthy initiative, launched by Pennington Biomedical Research Center, aims to prevent and treat childhood obesity in Louisiana. Studies show that childhood obesity is a national healthcare crisis in Louisiana, with over 1 in 3 children living with overweight or obesity.
Renowned cancer clinician Dr. Daniela Matei will lead the Houston Methodist Dr. Mary and Ron Neal Cancer Center, bringing expertise in ovarian cancer treatment and therapeutics. She aims to bridge laboratory science to the clinic, advancing new concepts from bench to bedside.
The foundation awarded $400,000 over two years to five early-career researchers and continuation support to three current Innovators with significant progress on their proposed research. The recipients focus on developing targeted therapeutics, decoding dendritic cell function, defining NKT cell interactions with tumors, engineering T ...
The International Society for Stem Cell Research has awarded the 2026 ISSCR Lifetime Achievement Award to Dr. Allen Eaves and late Dr. Connie Eaves, recognizing their groundbreaking work on blood stem cell biology, leukemia, and cancer stem cells. Their research and mentorship have profoundly influenced the field of stem cell science.
Aviv Regev, a pioneering computational biologist, will deliver a keynote address on tissue stem cells at the ISSCR 2026 Annual Meeting. Her work has transformed our understanding of cell and tissue function in health and disease.
The partnership aims to develop next-generation mRNA vaccines with enhanced stability and targeted delivery, providing broader protection against emerging pathogens. This collaboration combines Ethris' mRNA technology platforms with DZIF's vaccine research expertise to accelerate the development of variant-ready vaccines.
A team of researchers uses CRISPR gene editing to eliminate cells with amplified oncogenes, reducing tumour growth and increasing animal survival. The study offers a promising approach for precision therapies in resistant cancers.
The journal welcomes Bo Shen, Ph.D., and Luca Peruzzotti-Jametti, M.D., Ph.D. as Early Career Editors, bringing complementary strengths in stem cell niche biology and metabolism to the editorial board. Their perspectives will help ensure rigorous peer review, relevance, and global engagement.
The ACHILLES project trains researchers in experimental haematological oncology, developing advanced models, analysis tools, and therapeutic targets for leukaemia and lymphoma. The project aims to bridge basic and preclinical research with clinical practice, improving survival rates and accessibility to innovative treatments.
Cancer cells tap into the nervous system's power grid by forming synaptic contacts with nerve cells, promoting tumor growth and spread. Venkataramani's research aims to repurpose the drug perampanel for glioblastoma treatment and develop gene therapy approaches to disconnect tumors from the nervous system.
The USF team aims to identify the role of lymphatic dysfunction in various diseases, including cancer, obesity and heart failure, through innovative imaging technologies and biomarker discovery. The project will create a new database to map how the normal lymphatic system should work.
The Critical Path Institute's Translational Therapeutics Accelerator is offering grants to support the development of new treatments for polycystic kidney disease, brain health, pediatrics, and rare diseases. C-Path has partnered with the PKD Foundation to offer a specialized track focused on PKD, and is also accepting applications fro...
A Purdue-developed mRNA therapy delivery system has shown promise in targeting bladder cancer cells with improved efficiency. The system, called LENN, can be freeze-dried and stored for several days without losing its biological activity.
Dan Devers joins the Stowers Institute with over 20 years of experience in law and business. He will lead all legal matters across the Institute, ensuring governance, compliance, intellectual property strategy, and partnerships support the Institute's mission to diagnose, treat, and prevent disease.
The new program combines limb preservation, amputation care, and reconstructive solutions like osseointegration to improve identity, functional outcome, and quality of life for patients. Patients will receive coordinated, personalized, and expert care that supports their recovery and promotes sustained overall health.
The American Pediatric Society has reinstated the APS Howland Visiting Professor Program at Vanderbilt University School of Medicine, enabling renowned pediatric leader Bonnie W. Ramsey, MD, to share her expertise and engage with academic professionals.
Dr. Noritaka Ichinohe challenges the long-held assumption that averaging away individual differences is necessary in psychiatric research. Instead, biological heterogeneity is seen as a phenomenon demanding explanation. The author's work on primate brain mapping and molecular subtyping has identified convergence points between species ...
The International Society for Stem Cell Research published its most downloaded papers of 2025, reflecting the field's scientific range from pluripotency to regenerative medicine. The journal's mission is to publish rigorous, transparent, and consequential science advancing discovery while informing clinical translation.
A new study from Texas A&M University reveals that circadian disruptions change the structure of mammary glands, weaken immune defenses, and fuel aggressive breast cancer. Disabling an immune checkpoint molecule called LILRB4 helps restore the immune system's ability to fight back.
Researchers developed RNACOREX, a new open-source software tool that identifies gene regulation networks in cancer. The tool analyzes thousands of molecules simultaneously to detect key interactions, providing an interpretable molecular map that improves understanding of tumors.
A novel approach to chronic pain management uses induced pluripotent stem cell-derived peripheral pain-sensing neurons to treat osteoarthritis joint pain. The therapy, SN101, sequesters inflammatory pain factors without transmitting pain signals, preserving joint tissues and relieving chronic pain.
The PerMiCCion consortium is studying the microbiome to develop personalized prevention and treatment strategies for early-onset colorectal cancer. They identified a characteristic 'oncogenic microbiome' that promotes inflammation and influences immune response.
The ISSCR symposium highlights new clinical trial results and emerging technologies advancing PSC-derived cell therapies. Key findings include breakthrough approaches for treating drug-resistant epilepsy and geographic atrophy, as well as durable remission in type 1 diabetes.
Pennington Biomedical Research Center launched its first international scientific symposium in Riyadh, Saudi Arabia, exceeding expectations with distinguished audience engagement and new institutional contacts.
The ESMO Immuno-Oncology Congress 2025 will discuss key developments in immuno-oncology, including combined approaches, AI in cancer therapy, and innovative strategies across various cancers. The congress aims to advance the field of immunotherapy and improve patient outcomes.
A study published in Science Translational Medicine reveals that overactive plasmacytoid dendritic cells contribute to continuous immune inflammation and weaken antiviral T cell function. Reducing these cells or combining with an immune checkpoint inhibitor can restore antiviral T cell function and shrink the viral reservoir.
Researchers at MSK found that Foxp3 degradation can inhibit cancer growth and enhance immune response. They also developed a system to detect loss of heterozygosity during gene editing, which is a common problem in DNA double-strand breaks.
A team at the University of Pennsylvania has solved the mechanism of action of hydralazine, revealing its potential to halt the growth of brain cancer cells. By blocking an oxygen-sensing enzyme, hydralazine can reduce intracellular calcium levels, causing blood vessels to relax and tumor cells to enter a dormant state.
Four researchers from LSU's Pennington Biomedical Research Center have been named among the world's most highly cited scientists. Dr. Steven Heymsfield, Dr. Peter Katzmarzyk, Dr. Eric Ravussin and Dr. Donna Ryan are recognized for their significant and broad influence in their respective fields.
Researchers found that the leptin-SCD pathway fuels breast cancer growth and motility, leading to poorer recurrence-free survival. Selectively blocking SCD activity can counteract pro-tumorigenic effects driven by leptin, revealing a potential therapeutic target for obese patients.
Researchers at UMC Utrecht are developing a predictive model to accurately predict disease progress in juvenile dermatomyositis. The Interferon Score aims to identify which children can safely reduce medication and which require intensified treatment.
A new AI model uses machine learning to predict drug toxicity in humans by identifying biological differences between cells, mice, and humans. The model improved predictive power over existing state-of-the-art models and demonstrated practicality in predicting market withdrawal due to toxicity.
Research from Michigan Medicine uncovers connections between a longevity gene, behavior, and environment, suggesting that manipulating stress responses could extend life without downsides. Touch activates a circuit modulating signals to reduce the longevity effect of dietary restriction.
Researchers at MSK Cancer Center developed laboratory models of VEXAS syndrome, a confounding inflammatory disease. They identified new insights into the disease's mechanisms and potential therapeutic targets by mapping molecular circuitry and blocking parts of the
New tools, such as CheatBlocker and QuotaConfig, help address challenges of data integrity in decentralized clinical trials. CheatBlocker detects fraud, while QuotaConfig ensures sample representativeness. These innovations aim to increase the reliability and security of remote clinical trials.
Pennington Biomedical researchers will participate in numerous panels and presentations during the conference, sharing their latest findings on obesity treatment and prevention. The institution is well-represented at the event, with faculty members among the experts leading courses, presentations, and speaker panels.
The Lehigh University team created a computational model to predict the hemodynamic response of patients with AFib, helping tailor neurostimulation dosages. The model validated against clinical data and predicted accurate effects on blood pressure, heart rate, and stroke volume.