Articles tagged with Translational Research
Researchers at MSK found that Foxp3 degradation can inhibit cancer growth and enhance immune response. They also developed a system to detect loss of heterozygosity during gene editing, which is a common problem in DNA double-strand breaks.
A team at the University of Pennsylvania has solved the mechanism of action of hydralazine, revealing its potential to halt the growth of brain cancer cells. By blocking an oxygen-sensing enzyme, hydralazine can reduce intracellular calcium levels, causing blood vessels to relax and tumor cells to enter a dormant state.
Four researchers from LSU's Pennington Biomedical Research Center have been named among the world's most highly cited scientists. Dr. Steven Heymsfield, Dr. Peter Katzmarzyk, Dr. Eric Ravussin and Dr. Donna Ryan are recognized for their significant and broad influence in their respective fields.
Researchers found that the leptin-SCD pathway fuels breast cancer growth and motility, leading to poorer recurrence-free survival. Selectively blocking SCD activity can counteract pro-tumorigenic effects driven by leptin, revealing a potential therapeutic target for obese patients.
Researchers at UMC Utrecht are developing a predictive model to accurately predict disease progress in juvenile dermatomyositis. The Interferon Score aims to identify which children can safely reduce medication and which require intensified treatment.
A new AI model uses machine learning to predict drug toxicity in humans by identifying biological differences between cells, mice, and humans. The model improved predictive power over existing state-of-the-art models and demonstrated practicality in predicting market withdrawal due to toxicity.
Research from Michigan Medicine uncovers connections between a longevity gene, behavior, and environment, suggesting that manipulating stress responses could extend life without downsides. Touch activates a circuit modulating signals to reduce the longevity effect of dietary restriction.
Researchers at MSK Cancer Center developed laboratory models of VEXAS syndrome, a confounding inflammatory disease. They identified new insights into the disease's mechanisms and potential therapeutic targets by mapping molecular circuitry and blocking parts of the
New tools, such as CheatBlocker and QuotaConfig, help address challenges of data integrity in decentralized clinical trials. CheatBlocker detects fraud, while QuotaConfig ensures sample representativeness. These innovations aim to increase the reliability and security of remote clinical trials.
Pennington Biomedical researchers will participate in numerous panels and presentations during the conference, sharing their latest findings on obesity treatment and prevention. The institution is well-represented at the event, with faculty members among the experts leading courses, presentations, and speaker panels.
The Lehigh University team created a computational model to predict the hemodynamic response of patients with AFib, helping tailor neurostimulation dosages. The model validated against clinical data and predicted accurate effects on blood pressure, heart rate, and stroke volume.
The European Society of Endocrinology (ESE) has announced the winners of the 2026 ESE Awards, which recognize outstanding contributions to improving knowledge and expertise in endocrinology. This year's winners include Martin Reincke for his work on neuroendocrinology and Maria-Christina Zennaro for her research on hypertension.
Cancer Communications, a new journal published through the AAAS Science Partner Journal program, aims to bridge global oncology insights and clinical impact. The journal welcomes submissions on various cancer research topics, including clinical trials, epidemiology, and molecular biology.
The Allison Institute's third annual scientific symposium featured a panel discussion with five Nobel laureates, highlighting breakthroughs in cancer vaccines, immunotherapy, and immunology research. The event also recognized scientific achievement and leadership through award presentations.
A study by the Gerald P. Murphy Cancer Foundation's Center for Exceptional Longevity Studies found that retaining gonad function can significantly impact frailty mortality risk. Male dogs with shortest testis exposure had high mortality risks, while those with longest gonad exposure showed no consequence of increasing frailty.
The National Institutes of Health has renewed Pennington Biomedical's Metabolic Basis of Disease Center for five years, providing $2.2M per year to support research on the mechanisms of metabolic health. The center aims to address the obesity epidemic and its related illnesses.
A new study by Texas A&M University Health Science Center reveals how TFE3 oncofusions hijack RNA to build liquid-like hubs that promote cancer growth. The researchers also created a molecular switch to dissolve these hubs, cutting off tumor growth at its source.
The winners of the Applied Microbiology International Horizon Awards 2025 have been recognized for their groundbreaking contributions to global challenges through applied microbiology. The awards celebrate excellence across various domains, including drug discovery and sustainable agriculture.
Recent studies from Sylvester have uncovered links between breast cancer, Superfund sites and social adversity. Researchers are also exploring the use of artificial intelligence (AI) in interpreting mammograms more accurately.
The European Society of Endocrinology has released the EndoCompass Research Roadmap, a major new initiative to align research efforts and improve funding strategies for hormone-related health challenges. The roadmap identifies specific research needs across eight endocrine specialties and five cross-cutting areas.
The ISSCR 2026 Annual Meeting will bring together academic and industry leaders to explore advances in stem cell science and regenerative medicine. Scientists can submit abstracts by February 25, 2026, for oral presentations and Travel and Merit Awards.
The four-day training program equipped postdoctoral fellows with state-of-the-art methods for clinical research in obesity, metabolism and nutrition. Participants deepened their skills in gold-standard methodologies crucial for advancing clinical and translational research.
University of Michigan researchers propose a technique called Dynamic Sensor Selection to identify disease biomarkers. The approach, which applies control theory and observability principles to biological systems, has been shown to pinpoint biomarkers at each time point and reduce data complexity.
Researchers at UMass Amherst have developed a nanoparticle-based vaccine that prevents melanoma, pancreatic and triple-negative breast cancer in mice. The vaccine achieved remarkable survival rates, with up to 88% of vaccinated mice remaining tumor-free.
The International Society for Stem Cell Research (ISSCR) has released a comprehensive guide to accelerate the translation of human pluripotent stem cell-derived therapies into clinical trials and commercial use. The guidance outlines key principles and decision points for developing safe, effective, and regulatory-compliant products.
A new review in Frontiers in Science calls for a fundamental shift in how heart drugs are discovered and tested using AI, omics, and big data. This approach could drive the development of personalized treatments for cardiovascular disease, which currently relies on broad-brush treatments that don't account for individual variability.
A research team led by Dr. Marina Lusic identified RNA:DNA hybrids as molecular signposts for the virus, providing new therapeutic approaches for controlling HIV reservoirs. Removing Aquarius enzyme significantly decreases integration rate and shifts to R-loop-poor regions.
A non-electronic soft robotic device guides a soft tube into the trachea, improving success rates for both expert and non-expert users. The device yields a 100% success rate with highly trained users and an 87% success rate with non-expert providers after just five minutes of training.
The study found that increasing Piezo1 activity leads to a coordinated response, resulting in increased skin surface area and thickness. The findings could ultimately help doctors develop noninvasive therapeutic approaches to create new skin for treating burns and other injuries.
The C-Path Translational Therapeutics Accelerator has completed a record year of funding and mentorship, supporting seven projects in 2025 with approximately $2.48 million in awards. The program awarded grants to teams advancing treatments for rare liver disease, drug-resistant lung infections and pediatric brain tumors.
Researchers found that individuals with more severe depressive symptoms had difficulty learning to actively avoid aversive sounds, but their ability improved once they mastered the task. The study suggests that depressive symptoms may specifically interfere with learning to avoid unpleasant events rather than avoidance in general.
The ISSCR will host its 2028 Annual Meeting in Copenhagen, Denmark, bringing together researchers, clinicians, industry leaders, and policymakers from over 80 countries. The event will support new frontiers in stem cell science and regenerative medicine, fostering global collaboration and discovery of cutting-edge scientific advances.
The University of California, San Diego's Altman Clinical and Translational Research Institute has received a seven-year, $80 million grant to accelerate progress in human health. The award supports workforce development programs, including mentorship opportunities for early-career scientists.
The Aging (Aging-US) meeting will bring together researchers and clinicians to explore the latest advances in cellular senescence and its translation into therapies for age-related diseases. The event will provide a unique platform for discussing both basic research and its clinical applications.
Silvia Blemker, a renowned biomedical engineer, has been elected to lead the American Society of Biomechanics. She aims to bolster industry ties, expand funding for students and early-career researchers, and promote interdisciplinary collaboration.
Researchers at the University of Illinois found that benign and cancerous breast calcifications have unique structures and formation processes. The study provides a new classification scheme and opens the possibility of treating benign calcifications using certain drugs.
The study reveals three new subsets of follicular T cells that increase in follicular lymphoma, each with distinct gene expression and spatial distribution patterns. These T-cell subsets serve as a strong predictor of patient prognosis, enhancing treatment approaches for the disease.
The National Multiple Sclerosis Society is offering funding opportunities for next-generation researchers and clinicians, as well as projects advancing women's health in MS. The American Brain Foundation and US Department of Defense are also providing grants for neuroinflammation research and clinical trials.
Dr. Natalie Artzi joins the Wyss Institute as Associate Institute Director, working closely with Don Ingber to shape strategic direction and advance research and translation efforts. She leads a world-class research program focused on developing tissue- and cell-responsive nanostructures for disease tracking and treatment.
A new smartphone app, ECHAS, can help people determine if they are suffering from a heart attack or stroke and need medical attention. The app, developed by experts at UVA Health and other leading institutions, proved effective in identifying patients with cardiac and neurological emergencies.
Moffitt researchers will present numerous oral and poster presentations covering a wide range of cancer types, including lung, breast, cervical and biliary tract cancers. The center's experts are also available to comment on various cancer research and care topics before and during the meeting.
Researchers found that denosumab increases tumour-infiltrating immune cells in early-stage breast cancer patients, particularly in type B luminal tumours. This increase is associated with a potential boost to the anti-tumor immune response and offers a valuable avenue for clinical interest.
Korea University's College of Medicine has been selected for 24 basic research projects, receiving a total of 17.3 billion won in research funds. Eleven professors will conduct research in six project fields.
The Boston Children's Therapeutic & Medical Device Accelerator has announced its inaugural awardees, selected for their groundbreaking innovations in pediatric healthcare. The program provides targeted funding, expert mentorship, and strategic collaborations to advance hospital discoveries towards clinical impact.
The inaugural Joint Congress brings together paediatric and adult endocrine specialists to learn from each other, collaborate, and celebrate endocrinology. Over 7,500 delegates from 100 countries attend the event to experience the latest research and developments.
A recent study found that a protein called URI degrades p53, leading to uncontrolled cell proliferation and tumour formation. Researchers have identified URI as a crucial regulator of p53 levels, which may be associated with environmental factors such as poor diet.
Researchers identified six risk groups for cardiometabolic complications in older people without type 2 diabetes, with a special high-risk group characterized by inflammation and insulin resistance. The study emphasizes the need for precise early detection and prevention strategies.
Dr. Ronald Newbold has been appointed as the permanent CEO of Empire Discovery Institute (EDI), a non-profit drug discovery and development accelerator. With over 30 years of business development experience, Dr. Newbold will lead EDI's growth and expansion, including the addition of new programs and partnerships.
The U.S. research ecosystem, fueled by high-performance computing, is facing a critical moment due to slow infrastructure growth and funding cuts. The National Science Foundation's staffing cuts will slow down the process of innovation, potentially harming the country's competitive edge in research.
The SMU project plans to provide accurate, low-latency, minimal maintenance indoor localization solutions using the one-sided RTT Wi-Fi feature. This technology can penetrate obstacles and work with any Wi-Fi AP, making it a reliable method for locating objects indoors.
Three University of Arizona Health Sciences faculty members have received career development awards to support their research. Erika Austhof will study the role of weather and ecological drivers in salmonella transmission, while Kristin Huntoon will investigate a drug for treating glioblastomas. Celina Valencia will examine the link be...
Hunter Medical Research Institute has formed a memorandum of understanding with Novartis (Aust & NZ) to explore future research projects focused on improving cardiovascular health. The partnership aims to accelerate innovation and enhance patient care through collaborative research initiatives.
A new drug-free intervention targets the root cause of progressive loss of neural function in SMA by gradually reawakening functionally silent motor neurons. Early results show improved leg muscle strength and walking in adults with SMA, regardless of symptom severity.
The Neuro-Oncology Translational Research Training Program aims to bridge laboratory discoveries and clinical applications in neuro-oncology, targeting glioblastoma and brain metastases. The program provides predoctoral and postdoctoral trainees with cutting-edge lab experience and mentorship across multiple disciplines.
Researchers have identified a key protein called Apex1 as a potential therapeutic target for stopping the immune system from attacking itself. By inhibiting this protein, harmful T cells that cause autoimmune diseases and allergies can be eliminated.
The alliance aims to generate evidence supporting national guideline inclusion and healthcare provider adoption of Myriad's Precise MRD test. The studies will explore the test's utility in breast, gastrointestinal, genitourinary and gynecological cancers.
A study led by Henry J. Pownall and Khurram Nasir found a strong link between the amount of free cholesterol in HDL and its accumulation in macrophages, which can contribute to heart disease. The researchers aim to develop new diagnostics and treatments for managing heart disease using HDL-free cholesterol as a biomarker.
EBViously aims to prevent infectious mononucleosis and secondary diseases such as ME/CFS, while also protecting against certain types of cancer. The company's innovative vaccine candidate uses virus-like particles derived from EBV to trigger a targeted immune response.
Dr. Vincenzo Sorrentino's research targets the mitochondria-proteostasis axis to promote healthy longevity, addressing significant challenges in Singapore where life expectancy gap poses a threat. He joins a diverse group of researchers to tackle universal challenges and build towards a healthier future for Singapore.
Dr. Aditya Bardia's appointment as Editor-in-Chief of Breast Cancer Research and Treatment reflects his expertise in targeted therapies and innovative research. He aims to foster innovation and disseminate knowledge benefiting patients and the scientific community through this journal.