Articles tagged with Translational Research
A multidisciplinary team will integrate existing data to develop a computational framework predicting how vaginal tissue changes in response to hormones. The project aims to identify relationships between hormone dynamics and tissue microstructure and mechanics, ultimately improving women's health outcomes.
The portal will support 35-40 university programs and centers nationwide, serving over 50 entities and facilitating connections between researchers, industry partners, and government representatives. NJIT's Center for Translational Research has already supported four startups and over 45 funded projects, including OppyAI and PFASolve.
The UVA Weber Symposium will discuss the latest research and advancements in metastasis, a complex area of cancer research and care. The event will bring together top scientists and physicians to present findings on cancer metastasis, genetics, and treatment considerations.
A new analysis from Cure reveals that universities can engage with industry through four distinct pathways, with bottom-decile institutions outperforming top-ranked universities in commercialization and entrepreneurship. The study found that universities can build meaningful partnerships by leveraging their strengths in specific areas,...
A new drug, Kamuvudine K-9, has been shown to preserve nerve fibers and halt neurological damage in a mouse model of multiple sclerosis. The drug, derived from HIV drugs, has been found to be more effective than existing treatments in restoring function and reducing inflammation.
The journal welcomes leading researchers with expertise in hematopoietic and muscle stem cell biology, advancing understanding of stem cell research in health and disease. Drs. Bonnet and Relaix bring significant breadth of expertise and commitment to rigorous science, enhancing Stem Cell Reports' impact.
The grant will build on TTUHSC's foundation in basic and translational research, expanding clinical engagement and implementation science. The university will engage communities to identify health priorities and develop sustainable solutions.
A new AI tool has been developed to predict treatment and survival outcomes in patients with advanced non-small cell lung cancer treated with immunotherapy. The tool consistently outperformed standard clinical biomarkers, achieving high accuracy scores in predicting survival outcomes.
Child cancer groups are urging a concerted effort to tackle pediatric sarcomas, a rare and aggressive form of childhood cancer. The groups propose three key priorities to improve collaboration, data sharing, and clinical infrastructure to translate discoveries into effective treatments.
Researchers develop biodegradable nanobone material that activates body's own healing properties to regrow bone, reducing need for invasive procedures. The material generates 80% more new bone than a material control and activates a key bone-repair growth factor with 10 times the level achieved using conventional methods.
Researchers at the University of Münster have found that using biomarkers to identify high-risk patients can significantly reduce the risk of kidney damage after major surgery. The approach has great potential to help sepsis patients too, and the team is working to incorporate these findings into international guidelines for the treatm...
Francesca Filbey, Ph.D., joins Center for BrainHealth as Deputy Director of Research, focusing on advancing research priorities, strengthening collaborations, and expanding impact. With expertise in addictive disorders and a strong track record of scientific excellence, Filbey aims to accelerate brain health research and its applications.
Prostate cancer affects 1 in 8 men, with 60% diagnosed in men 65 and older. Clinical trials like Alliance's help improve early detection and treatment, reducing mortality rates by half since 1993. These trials also explore new treatments and survivorship strategies.
Researchers have created a high-resolution functional map of human immune cells, revealing intricate circuits that govern health and disease. The dataset provides a powerful framework for designing cancer immunotherapies and treating autoimmune conditions, and serves as a foundation for AI models of biology.
Txn1 mutant rats exhibit severe kidney deterioration, with hallmarks of human CKD, including oxidative stress, mitochondrial dysfunction, and inflammation. The study identifies a link between chronic thioredoxin deficiency and CKD progression, suggesting promising therapeutic approaches.
The 2026 Childhood Obesity Conference, 'Be the Reason Kids Greaux Healthy,' will explore strategies for preventing and treating childhood obesity, bringing together healthcare professionals, researchers, educators, and community leaders. The conference will feature keynotes, sessions, and poster presentations on emerging topics in pedi...
Critical Path Institute (C-Path) has achieved ISO/IEC 27001:2022 certification, demonstrating its commitment to protecting sensitive information and partner trust. This certification reflects the organization's structured risk-based information security management system.
The RadiCaL study, the first randomized trial of a radiopharmaceutical in kidney cancer, found that adding radium-223 to the standard of care does not improve skeletal event-free survival. Patients who received the combination treatment lived a median of 28.3 months, compared with 19.7 months for those who received cabozantinib alone.
Dr. Lorenz Studer is known for his pioneering advances in stem cell biology, regenerative medicine, and the development of stem cell-based therapies for neurodegenerative disease.
A new wearable electric-field device has been shown to slow the growth and spread of aggressive breast cancer in preclinical models. The technology uses low-intensity electric fields that interact with cancer cells in a controlled way, reducing tumor growth and increasing immune responses.
The Human Cancer Model Initiative released a compendium of more than 150 organoid models of 25 types of cancer, which are now available to scientists worldwide. These patient-derived organoids provide state-of-the-art research tools for accelerating discovery and developing personalized treatment strategies.
Massey Comprehensive Cancer Center awarded $2.7M K12 grant to support multidisciplinary cancer research and mentor early-stage clinical investigators. The grant aims to optimize participation by high-risk individuals in Virginia.
Researchers developed a framework to integrate AI into hospitals, emphasizing patient care, staff experience, and economic sustainability. The Total Mission Value framework aims to ensure high-quality patient care remains the top priority amidst AI's transformative potential.
A new drug, daraxonrasib, has been identified as a potential treatment for patients with NRAS-driven melanoma. The therapy targets and inhibits RAS protein, which drives cancer growth when mutated. Early results from preclinical models suggest the drug may be effective in treating advanced disease.
Researchers have developed a new drug candidate, SB-0110, that boosts L-dopa's benefits while reducing dyskinetic side effects in animal models of Parkinson’s disease. The compound preserves the gene-activity patterns tied to L-dopa’s benefits while counteracting biological changes associated with dyskinesia.
The symposium marked the hospital's designation as a research-oriented hospital, featuring discussions on collaborative research ecosystems at various levels. Participants engaged in sessions covering future directions, strengthening regional and industry collaborations, and real-world cases of research commercialization.
Researchers at Texas A&M University have found a way to intervene early in traumatic brain injuries using a natural, gut-derived chemical that prevents post-traumatic epilepsy from taking root. The treatment reduced brain inflammation, improved memory and mood, protected brain cells, made seizures both rarer and harder to trigger.
Researchers at Technion-Israel Institute of Technology discovered that mature, aged cells can revert into active stem cells that regenerate damaged tissue. This finding challenges the prevailing view on tissue regeneration and implies the possibility of therapies promoting natural healing mechanisms.
A new $250,000 grant will support the development of a novel therapeutic approach for sepsis-associated neurocognitive dysfunction. The treatment aims to protect the brain from inflammation-related damage during and after sepsis, potentially preventing or slowing neurodegeneration and cognitive decline.
A Phase 1/2a clinical study demonstrates long-term survival of transplanted human neural progenitor cells in patients with retinitis pigmentosa, maintaining a favorable safety profile. Visual acuity remained stable, and imaging showed cells remaining present in the subretinal space for at least one year.
The International Society for Stem Cell Research convenes its 2026 Annual Meeting in Montréal, showcasing groundbreaking discoveries and emerging clinical advances. The meeting features nearly 1,300 scientific posters and presentations spanning every area of stem cell research.
The Korea University College of Medicine and UNIST have been selected for the Ministry of Health and Welfare's K-MediST program, aiming to establish a leading model for integrated education and research in medical science and technology. The partnership will create an innovative interdisciplinary hub bridging medicine and engineering.
A new study published in Nature links casdatifan, an investigational HIF-2a inhibitor, to improved clinical outcomes in metastatic clear cell renal cell carcinoma (ccRCC) patients. Deep suppression of serum EPO correlated with higher response rates and longer progression-free survival.
Researchers at the German Center for Infection Research have developed a promising single-dose malaria treatment called SPAP, which targets the malaria parasite through multiple mechanisms. The four-drug combination therapy has shown significant promise in improving malaria treatment and could be a major advancement in sub-Saharan Africa.
The US retains its scientific edge but is losing the race to translate discoveries into cures, warns a new report from Cure Innovation Index. Without immediate renewed investment and policy changes, the US scientific edge will not hold.
The University of Virginia has joined SPARK GLOBAL to leverage resources and expertise in accelerating the development of new medicines. This collaboration aims to reduce time from lab discoveries to clinic trials, delivering tangible healthcare solutions to patients.
Dr. Jennifer Guida, a renowned researcher and program director, has been appointed as the first director of HonorHealth Research Institute's Division of Institutional Research. She will oversee the institute's clinical trials efforts, providing patients with pioneering treatments based on internal research discoveries.
The Columbia University Irving Medical Center has received a $75 million Clinical and Translational Science Award from the National Institutes of Health. This funding will support translational science at CUIMC, advancing biomedical research from bench to bedside.
Research waste refers to wasting scientific resources due to poor practices, compromising internal and external validity. JMIR Metascience and Research Integrity publishes metascience articles exploring the shortcomings of published literature and investigating its negative impact on real-world outcomes.
A pilot study of the Participant Engagement Portal (PEP) tool shows that 84% of participants had a positive experience, with high usability and satisfaction rates. PEP facilitates two-way communication between patients and clinicians, allowing for self-reporting of social risk factors and future research opportunities.
A study found that most persistent viral detection despite effective therapy is due to defective, non-infectious virus copies. The 5'-leader region of the virus is responsible for producing infectious particles, but defects in this area prevent the generation of functional viruses.
Researchers developed a senolytic therapy using dasatinib and quercetin, which preserved disc structure and reduced inflammation, highlighting JUN signaling as a key pathway. This preclinical study provides evidence for a potential therapeutic strategy to slow disease progression in individuals with genetic susceptibility.
The UMass Center for Clinical and Translational Science has received a seven-year, $50 million grant from the NIH. The funding supports collaboration among researchers at multiple UMass campuses and clinical partners.
Odylia Therapeutics is advancing a gene therapy treatment for Usher Syndrome Type 1C (USH1C)-associated vision loss, a rare autosomal recessive disorder. The grant will support the development of an investigational USH1C gene therapy designed to restore or preserve vision.
A new mRNA-based strategy amplifies the T-cell response to vaccines, enabling more powerful cancer vaccines and stronger protection against infectious diseases. The approach reprograms immune cells from within using mRNA instructions that expand cancer-fighting T cells.
Korea University College of Medicine has established a full-cycle physician-scientist training system from undergraduate studies to graduate school, fellowships, and professorships. The institution will further improve the path of physician-scientists with support from the Korea Health Industry Development Institute.
The summit brought together endocrine leaders to identify opportunities to work closely together on increasing the visibility of endocrine health in policy decisions. Early findings from a workforce survey revealed challenges including long patient waiting times and retention concerns among early-career clinicians.
A study of 308 participants found that those with higher baseline ePTFp concentrations experienced a significantly steeper decline in kidney function over time. This association remained significant even when serum phosphate concentrations were within normal range.
The Cure Innovation Index ranks top US biomedical institutions based on their ability to translate scientific discoveries into real-world healthcare solutions. The index identifies key factors such as commercialization infrastructure, industry engagement, and entrepreneurial culture that enable translational success.
A new targeted therapy has shown strong results in preclinical studies against aggressive childhood and adult cancers, eliminating tumours and stopping cancer spread. The therapy targets the IL1RAP protein, which is found on cancer cells but largely absent from normal tissues, allowing for precise delivery of treatment.
A study mapped early molecular and cellular changes in the jaw joint that may trigger temporomandibular joint osteoarthritis. The research found structural and molecular changes in joint tissues, including inflammation, fibrosis, and metabolic shifts. Single-cell sequencing revealed diverse cell populations interacting within the synov...
Lindsay Squeglia, Ph.D. of the Medical University of South Carolina received the 2026 ACTS Award for Supporting an Excellent Translational Science Workforce. She is a leading figure in substance use prevention and adolescent brain development research.
The Stem Cell Report podcast has marked five years of exploration in stem cell research, capturing significant progress in human development, disease, and regenerative medicine. The anniversary episode reunites past guests to discuss the field's evolution, highlighting advances in therapies, organoid systems, and global standards.
Scientists at the University of Virginia Health System have developed a suite of AI-powered tools, called YuelDesign, YuelPocket and YuelBond, to transform how new drugs are created. These tools can design drug molecules tailored to fit their protein targets exactly, even accounting for protein flexibility.
The San Antonio Breast Cancer Symposium generated nearly $40 million in economic impact and drew over 11,000 attendees from 104 countries. The symposium also produced $1.5 million in local tax revenue and supported more than 6,800 jobs.
The BiliSeq test detected approximately 82% of bile duct cancers, compared to 44% with pathology alone, and increased cancer detection to nearly 90% when combined with pathology. This improved accuracy enables physicians to provide more personalized medicine and treatment options for patients.
The Accelerating Cancer Cures Research Symposium brings together Damon Runyon scientists and industry partners to foster communication and collaboration. The symposium features updates on research aimed at developing more precise targeted therapies for cancer treatment.
Researchers at Memorial Sloan Kettering Cancer Center discovered that skin stem cells possess a remarkable form of inflammatory memory that can last over a year. This finding has implications for understanding how repeated inflammation affects skin aging and disease susceptibility. The study used MSK-IMPACT, a tumor sequencing test, to...
The University of Missouri is honoring three distinguished faculty members as 2025 AAAS Fellows. Paul de Figueiredo is being recognized for his contributions to microbiology, while Roman Ganta advances research on tick-borne diseases. Wesley Warren's expertise in genome-scale data analysis has reshaped research across multiple fields.
The BrainHealth Network connects researchers across the country to understand brain health improvement through advanced MRI imaging and data analysis. The network leverages a comprehensive multimodal brain imaging dataset, including a longitudinal study of 100,000 healthy participants over 10 years.