Articles tagged with Translational Research
Researchers developed an AI-based method to analyze kidney lesions in female patients with Alport syndrome, predicting renal prognosis and guiding treatment interventions. The approach uses a modified stain and deep learning to detect basement membrane lesions, showing a positive correlation with proteinuria concentration.
Dr. Bonnie W. Ramsey is recognized for her significant contributions to advancing child health and the profession of pediatrics. Her work on cystic fibrosis has dramatically improved life expectancy for children with the disease.
A new technique called Clonal competition assays helps understand the evolutionary advantages of multiple myeloma cells over available treatments. It allows researchers to see how each population of cells in the same myeloma reacts to treatments, getting closer to understanding heterogeneity and resistance.
The Northwestern University Clinical and Translational Sciences Institute has received $55 million in NIH funding to accelerate the development, evaluation, and implementation of improved healthcare interventions. The grant will support the development of effective health interventions for more patients more quickly, with a focus on ad...
A multi-university research team led by University of Virginia engineering professor Gustavo K. Rohde has developed a system that can accurately spot genetic markers of autism in brain images. The system uses generative computer modeling technique called transport-based morphometry, which reveals brain structure patterns that predict v...
The Wake Forest University School of Medicine has been awarded a $28.2 million grant from the National Institutes of Health to accelerate the translation of scientific discoveries. The grant will support initiatives such as rapid response to health emergencies and the recruitment of diverse academic learning health system workforce.
The new guidelines from the Surgical Infection Society offer updated recommendations for antimicrobial agent selection, source control, and treatment of specific pathogens. These evidence-based guidelines aim to improve clinical outcomes and reduce mortality rates from intra-abdominal infections globally.
A new approach in vaccine research, adaptive platform trials (APTs), offers a flexible adjustment of study design during ongoing clinical trials. This allows for quick adaptation to new developments and enables the recruitment of large numbers of participants across different countries.
A collaborative effort between The Academy of Breastfeeding Medicine and Reaching our Sisters Everywhere identified key components of a successful breastfeeding journey as defined by parents and families. The findings aim to inform research priorities and promote patient-centered outcomes in infant and young-child feeding.
Researchers at the Lewis Katz School of Medicine will investigate how injured heart cells communicate with other cells throughout the body using microvesicles known as exosomes. The study aims to understand how specific molecules, such as microRNAs, facilitate communication pathways between cells in the heart and vasculature.
A first-of-its-kind study compared preventative therapy efficacy between two groups: gene therapy alone and in combination with risdiplam or nusinersen. Dual therapy showed promise in independent sitting outcomes, but not in walking age or muscle disease progression prevention.
The Collaborative Ethics model, developed by Jeantine Lunshof and Julia Rijssenbeek, aims to address ethical implications of emerging technologies from fundamental discoveries. By integrating philosophical and ethical reassessment into research processes, the model facilitates decision points for researchers and ethicists.
A potential new strategy for reducing diabetes risk associated with antipsychotic medications involves co-administering drugs that block dopamine receptors in the brain alongside those that stop these same receptors in the pancreas. This approach may limit metabolic side effects and improve glucose metabolism.
Sharon Giordano and Richard Gorlick will be honored with Special Awards at the 2024 American Society of Clinical Oncology Annual Meeting for their dedication to improving cancer treatment and patient outcomes. Their research has made significant contributions to the field of oncology, with a focus on breast cancer and pediatric oncology.
Scientists have discovered the transporters responsible for delivering essential nutrients choline and ethanolamine to human cells. The study sheds light on the atomic structure of these transporters and their role in distributing micronutrients throughout the body, providing a foundation for new therapeutic approaches.
Researchers at UMSOM identified a modified sugar molecule that enhances human neural stem cells' proliferation and transition into neurons, improving brain function and reducing anxiety and depression. The study provides a promising proof of concept for regenerative medicine in patients with cardiac-arrest induced brain injuries.
Researchers at the University of Missouri have developed a soft, self-charging material that can track vital signs like blood pressure and heart activity wirelessly. This innovation has significant implications for early disease detection and timely interventions in chronic conditions.
Clinical trials show decreased effectiveness of vancomycin in treating C. diff infection, with reduced cure rates and lower sustained clinical responses associated with antimicrobial resistance. The finding poses a significant concern for the management of C. diff infection, with only two recommended antibiotics available.
The University of Birmingham's Drug Discovery Hub has developed a novel approach to drug discovery, enabling projects to overcome the funding gap between original research and commercial investment. The hub has attracted over £4m in industry funding, grants, and awards, with a successful portfolio of projects.
A new complex-carbohydrate biomolecule has been identified as crucial for Bordetella bacteria to colonize the nose and transmit to a new host. The discovery opens up possibilities for creating a new drug or vaccine that interferes with this glycan, potentially eliminating whooping cough transmission.
Researchers discover how S1P molecules are released from SPNS2 protein via small cavities, enabling potential treatment for inflammatory diseases. The study provides a foundation for designing future drugs targeting the protein.
A new special issue of Calcified Tissue International & Musculoskeletal Research sheds light on sarcopenia's pathogenesis, clinical implications, and therapeutic targets. Researchers have made significant progress in evaluating, managing, and developing interventions for this condition.
Researchers develop injectable hydrogel electrodes for treating ventricular arrhythmia, providing a potential solution to painful defibrillation and improving quality of life. The novel pacing modality addresses the pathophysiology of re-entrant arrhythmia and offers a promising alternative to existing therapies.
Researchers found that specific microbes in the gut reduce graft versus host disease after stem cell transplantation. Patients with low microbial metabolite risk index had better survival rates, fewer graft vs. host reactions, and reduced relapses.
Binghamton University will receive $6 million from the NSF to translate cutting-edge research into real-world applications and promote regional entrepreneurship. The initiative aims to increase the university's capacity for translational research, providing students with practical training and career development opportunities.
A team of University of Maryland researchers developed a nasal spray vaccine that delivers the SARS-CoV-2 spike protein into cells of the airway, triggering an immune response that significantly reduced infection and spread of COVID-19. The technology can be adapted to induce immunity to other respiratory illnesses.
A pioneering collection of brain metastasis living samples has been established, enabling researchers to study the response to specific drugs and identify the best therapeutic options for each patient. The RENACER network connects hospitals and patients, facilitating the rapid sharing of research findings and clinical trial data.
The Cumming Global Centre for Pandemic Therapeutics is offering global grants of up to $200,000 per annum for three years to develop novel therapeutics for pathogens of pandemic potential. Researchers are invited to submit expressions of interest for Round Two of the Foundation Grants program.
The NYSCF – Robertson Stem Cell Investigator Awards support promising early career scientists with cutting-edge research, providing $1.5 million over five years for seed funding. The latest cohort includes three talented researchers who will join the thirteenth class of NYSCF – Robertson Stem Cell Investigators.
A recent NIH grant will support research into the genetic factors contributing to cardiac arrhythmia, a condition affecting millions of Americans. The study aims to identify specific genes linked to arrhythmia risk and develop novel therapeutic approaches.
A University of Melbourne research team is developing an oral therapeutic to restore the activity of common antibiotics used to treat community-acquired bacterial pneumonia. The project aims to combat antibiotic-resistant bacteria and reduce healthcare costs, with potential applications in low- and middle-income countries.
Veterinary researchers used 3D organoids to investigate lung cancer in dogs, finding that canine primary lung cancer organoids faithfully mirrored tumor tissues. The study identified correlations between organoid cell viability and specific target molecules, paving the way for personalized treatment approaches.
Researchers propose that cerebrospinal fluid leaks could contribute to the link between traumatic brain injury and dementia. The hypothesis suggests that treating these leaks could mitigate dementia symptoms in some patients with a history of TBI. Further research is needed to confirm this potential association.
The South Carolina Clinical and Translational Research Institute's program provides early-career clinicians with the time and training needed to establish a sustainable portfolio of clinical trials. Scholars attend 'meet the expert' presentations, discuss strategies with mentors, and select suitable trials.
Researchers found that rodents exposed to light for the first time in adulthood showed significant plasticity in their brains, challenging previous beliefs about adult brain rigidity. After a month, their brains looked similar to those of healthy controls, with organized visual responses and smaller receptive fields.
Researchers at the University of Missouri have developed a new type of nanoclay material that can be customized to perform specific tasks. This breakthrough could lead to advances in fields such as medical science, environmental science, and more.
Rice University engineers developed a low-cost, point-of-care DNA test for HPV infections that can be used to screen for cervical cancer. The test, which requires just two pieces of equipment and delivers results in 45 minutes, has the potential to make cervical cancer screening more accessible in low- and middle-income countries.
An Australian interview study suggests that advance research directives (ARD) can facilitate informed consent for people with dementia. The study also highlights the importance of family members as proxy decision-makers. In another article, a competency framework is proposed to improve health research ethics education.
Researchers used unbiased genetic screening to identify genes involved in regulating sleep in worms, finding that proteins play a crucial role. These findings suggest new approaches for preventing diseases related to sleep disturbances and inflammation.
A new partnership between Patrick Reed and Kenneth Eilertsen is putting a focus on translational research and commercialization at Pennington Biomedical. The team aims to evaluate patentability and marketability of potential disclosures, promoting public benefit from scientific discoveries.
Dr. Carol Feghali-Bostwick received an award for contributing to the diversity and inclusiveness of the translational workforce, while Dr. ReJoyce Green was recognized with the Outstanding Trainee: Post-Doctoral Award for her high productivity and impact in public health.
Researchers at Cedars-Sinai Medical Center identified a genetic variant associated with increased risk of developing perianal Crohn's disease, a debilitating manifestation of Crohn's disease. The study highlights the importance of targeting the alternative complement pathway and Complement Factor B (CFB) in treating this condition.
Researchers used a novel brain imaging technique to visualize subtle brain changes in pre-symptomatic Alzheimer's patients. They found that individualized brain fingerprints can detect variations in brain function associated with worsening information processing.
The Albert Einstein College of Medicine and Montefiore Health System have received a seven-year, $30 million grant from the National Institutes of Health to continue supporting the Harold and Muriel Block Institute for Clinical and Translational Research. The grant will advance translational science and health equity by accelerating th...
A multicenter study found that patients with cystic fibrosis can safely take a dual combination of CF modulator drugs for four years while maintaining previously achieved clinical improvement. This breakthrough therapy has improved the quality and length of patients' lives, with some even seeing a 15% increase in lung function.
Researchers developed a deep learning-based AI model to automate cirrhosis identification using large amounts of data from EHRs. The model successfully identified patients with cirrhosis with a precision of 97%, offering potential for early diagnosis and improved management of the disease.
Researchers have developed a new imaging approach to diagnose advanced non-alcoholic fatty liver disease (NASH). The enzyme-sensitive nanoprobe emits signals that can be detected by MRI techniques, providing more accurate and sensitive data for diagnosis. This breakthrough aims to improve the treatment outcomes of NASH patients.
A new cell therapy has demonstrated significant benefits in improving the heart's pumping ability and reducing the risk of cardiovascular death, heart attack, or stroke in patients with chronic heart failure. The therapy, using mesenchymal precursor cells (MPCs), also showed a strong signal in reducing inflammation and improving microv...
Researchers found that a pro-oxidant mixture of resveratrol and copper can inactivate cell-free chromatin particles, reducing chemotherapy toxicity. The treatment also showed promise in preventing aging and sepsis.
Dr. Keith Chan joins Houston Methodist to enhance chemoimmunotherapy responses in bladder cancer, while also expanding research into pancreatic and skin cancers. He will lead translational research and mentor next-generation cancer researchers.
The NSF is seeking proposals to utilize the ISS National Laboratory for fundamental research in fluid dynamics, thermal transport, and combustion. Researchers aim to advance knowledge that benefits life on Earth, particularly in predicting and preventing catastrophic mudslides after wildfires.
Researchers at UNIGE and LMU discovered that immune system's anti-tumour activity peaks in the morning. Tumours implanted at night grew faster than those implanted in the afternoon. Administering immunotherapy treatments early morning significantly enhanced their effectiveness, suggesting a new strategy for cancer treatment.
The West Texas Pharmacology Core laboratory at TTUHSC will focus on two primary areas: drug development and pediatric cancer. The core aims to address obstacles in drug development, including limited pharmacology expertise for small biotech companies and low profitability for pediatric cancer drugs.
Researchers developed a machine learning model to quickly recognize predictive risk factors and their importance for undesirable hospitalization outcomes. The model achieved an accuracy of 95.6% and identified modifiable risk factors that can be mitigated through clinical interventions.
Researchers at UMC Utrecht will investigate how intestinal microbiota impacts cancer immunotherapy and therapy side effects. The project aims to develop microbiota-targeted therapies to improve ICI treatment effectiveness and reduce severe inflammation.
Researchers at LSU Health New Orleans have identified a critical immunosuppressive pathway and developed an experimental inhibitor to protect T-cells from weakening. The CBL-B inhibitors show great potential in enhancing the efficacy of cancer immunotherapy, making patients' T-cells more effective in killing cancer cells.
The University of Cincinnati is conducting a study on a potential new treatment for pancreatic cancer using SapC-DOPG, a nanotechnology drug delivery system. The treatment has shown promise in reducing tumor growth by 50-80% in animal models and aims to develop an effective immunotherapy treatment.
A new software program, Mistic, allows for the simultaneous viewing of tissue images through dimensionality reduction methods. The software enables the extraction of data from multiplexed images, facilitating the understanding of cancer biology and the development of new therapies.
Researchers found that CXCL9 levels were higher in pre-fracture blood samples of Chinese men with subsequent hip fractures, improving the prediction of osteoporotic hip fracture risk in men. In contrast, no association was found between CXCL10 and hip fracture risk in either gender.
A new gene therapy for sickle cell disease was tested in mice but proved ineffective due to the complex genetic make-up of the Berkeley mice. The study suggests that researchers should carefully consider the genetics of the mice used to test human diseases.