Articles tagged with Transplantation
A new analysis found that post-heart transplant survival among older patients is on par with younger recipients. The study included 37,135 patients and showed a significant improvement in mortality rates after adjusting for other factors, suggesting that advanced age should not be a contraindication for heart transplantation.
A new study led by Katie Barott found that climate change-resistant corals can thrive in different environments and maintain their resilient qualities after transplantation. The research suggests that these hardy corals could serve as a founding population to restore reefs in the future.
Patients at for-profit dialysis facilities are less likely to be referred for kidney transplantation compared to those at non-profit facilities. Rates of starting medical evaluations and placing patients on a waitlist after evaluations were similar between the groups.
Research presented at the ATS 2021 International Conference found that patients with idiopathic pulmonary fibrosis (IPF) living in poor neighborhoods experience poorer outcomes, including increased mortality and reduced odds of receiving a lung transplant. The study highlights the impact of environmental factors on disease progression.
A pharmacist-led smartphone app has been shown to significantly improve medication safety and reduce hospitalizations in kidney transplant recipients. The study found that participants who used the app were 61% less likely to experience medication errors and 45% less likely to experience serious side effects.
A study of renal transplant biopsies found that blood pressure thresholds above 180/95/116 mmHg don't increase complication risk, but combined high pressures do
Researchers at UHN have developed a deep learning model that can significantly improve long-term survival and quality of life for liver transplant recipients. The model is based on a large dataset from the Scientific Registry of Transplant Recipients and has been validated using a local dataset from UHN's Ajmera Transplant Centre.
A study of nine uterine transplants from living donors has provided an initial estimate of costs, with total average cost per transplant reported as EUR 74,564. Sick leave accounted for the largest portion of these costs.
Researchers at NIH/National Human Genome Research Institute developed a breath test to measure how well patients with methylmalonic acidemia respond to liver or combined liver and kidney transplants. The test assesses the severity of the disease and helps determine treatment efficacy.
A new study by Uppsala University found that unmarried patients and those with low educational attainment are less likely to be treated with a stem-cell transplantation for mantle cell lymphoma. The study suggests that this may result in poorer survival rates.
A recent study found that enrolling Black patients on the waitlist with slightly better kidney function could reduce racial disparities in transplant access. This approach aims to bridge the gap between Black and white patients' wait times before kidney failure, ultimately promoting greater equality in transplantation.
Despite policies and interventions aimed at improving access to kidney transplantation, a new study found no overall improvement in rates of wait list placement and transplantation over two decades. The researchers also identified striking disparities in access to transplantation, highlighting the need for more effective strategies to ...
A study of over 23,000 heart transplant recipients found that young Black adults are more likely to die in the first year after a transplant. Researchers attribute this disparity to factors such as limited access to healthcare and specialized care.
The study found that racial disparities in kidney transplantation persist despite advances in the field. Blacks are more likely to develop kidney failure but less likely to undergo transplantation, particularly from living donors.
A new international study documents the physiology of dying and confirms that death is an irreversible process. The DePPaRT study found that cardiac activity often stops and restarts several times during the dying process, but no one regained sustained circulation or consciousness. This provides evidence to support the current standard...
Researchers developed a risk score to prioritize liver cancer patients for transplantation, accounting for both cancer-related and non-cancer-related factors. The LiTES-HCC score predicts post-transplant survival for hepatocellular carcinoma patients, leading to more efficient allocation of livers.
A new study found that non-Hispanic white patients are disproportionately placed on liver transplant waitlists, with disparities attributed to private health insurance access and travel distance. The researchers suggest increasing awareness of these trends may promote equitable access to transplants.
A virtual telehealth platform allows patients to undergo comprehensive evaluation for kidney transplantation from the comfort of their own homes. This innovative approach has enabled the Medical University of South Carolina's transplant program to maintain access to life-saving surgeries despite pandemic restrictions, with over 282 pat...
Researchers analyzed ten cancer patients with refractory melanoma and found that fecal microbiota transplant improved patient outcomes in three out of ten cases. The treatment was safe and feasible, suggesting a potential role in overcoming resistance to anti-PD-1 immunotherapy.
Researchers analyzed gut composition and DNA to identify key factors for successful fecal microbiota transplants, including the donor's microbiome and recipient's pre-transplant gut community structures. The study suggests that preparing donors' and patients' gut ecosystems prior to transplant may increase the likelihood of success.
Research found Afro-Caribbean patients with end stage kidney disease have a four-fold increased risk of being hospitalized with COVID-19 compared to other ethnicities. The study also showed that patients with ESKD are vulnerable to severe COVID-19 infection and require integrated multidisciplinary care.
Social determinants like discrimination, depression, and mistrust predict patient-reported quality of life in kidney transplant patients. Lower medical mistrust leads to greater patient satisfaction with clinical services.
A new research letter found that clinicians gave more patients temporary mechanical pumps under the new policy, moving them up the transplant list. This could lead to a higher likelihood of prioritizing male patients over females.
Researchers identified process and outcome indicators to monitor transplant center performance in evaluating potential living kidney donors. The study aims to improve efficiency and increase living kidney donations.
Researchers discovered that transplanting bacteria from sleep-apnea mice into healthy mice altered their sleep patterns, suggesting a major role for the gut microbiome in regulating sleep. The study's findings may lead to new treatments targeting the gut microbiome in humans with obstructive sleep apnea.
A new study published in Gastroenterology found that consuming frozen microbiome capsules derived from their own feces when dieting may limit weight regain. Participants who followed a green-Mediterranean diet and received fecal microbiome transplantation lost more weight and regained less weight compared to those on other diets.
This observational study found that advanced treatment protocols significantly improved survival rates for heart transplant waiting list patients. Researchers examined data from over 11,000 patients and discovered a strong correlation between timely interventions and better outcomes.
Researchers found that native lizards harbor parasites controlling invasive species, keeping their populations under control. The study suggests biodiversity is a key factor in resisting invasions.
A new online tool developed by Hennepin Healthcare Research Institute and the University of Minnesota helps transplant candidates find matching programs based on their donor type and medical profile. The website uses data from the Scientific Registry of Transplant Recipients (SRTR) to provide personalized decision support.
Researchers found that pairing bariatric surgery with LVAD heart surgery improved the eligibility of previously ineligible patients for heart transplants. After a year, 66% of patients met listing requirements and 33% received transplants.
The study observed changes in waitlist inactivations and additions, donor recovery rates, and heart transplant volumes during the COVID-19 pandemic. These changes varied by region and were likely influenced by pandemic-related factors such as lockdowns and social distancing measures.
Two new studies investigate COVID-19 in kidney transplant recipients, finding most don't need hospitalization, and patients on dialysis may experience different symptoms. Additionally, another study reveals distinct clinical features of dialysis patients with COVID-19, highlighting the need for more research and guidance.
A new heart box method has shown clear signs of improvement in preserving and transporting donated hearts, reducing the risk of complications. The method enables longer preservation times, which could lead to more opportunities for transplants, including international flights.
A new study found that fecal transplants can reduce intestinal permeability in patients with non-alcoholic fatty liver disease (NAFLD), a condition associated with metabolic syndrome and autoimmune diseases. The treatment shows promise for improving gut health and preventing further inflammation.
A study of 13 black male heart transplant patients with COVID-19 reveals higher rates of mortality and critical illness compared to non-transplant recipients. The researchers call for further research on racial and gender disparities in COVID-19 and its management in immunosuppressed patients.
A recent analysis found that kidney transplant patients are at a higher risk of death from COVID-19, with advanced age being the most significant factor. The study, conducted on ERACODA database, showed that 21% of kidney transplant recipients died within 28 days, compared to 25% of dialysis patients.
A comprehensive study published in the Journal of Hepatology shows women and men have similar mortality rates from cirrhosis, contradicting previous research. The study analyzed data from 20,045 patients with cirrhosis, finding no difference in liver-related cause of death between genders.
A new study found that patients with lower socioeconomic status and additional illnesses are less likely to be put on transplant waiting lists in the UK, despite universal healthcare. The study suggests that patient factors, such as age and health literacy, play a significant role in determining access to transplantation.
Women awaiting liver transplants face higher mortality rates than men due to various factors, including geographic location and medical urgency. Liver size also plays a role in these disparities, highlighting the need for targeted interventions to address sex-based inequalities.
Researchers from University Hospital of Toulouse treated a severely ill patient with COVID-19 using tocilizumab, a biological agent targeting inflammatory cytokines. The patient showed dramatic improvement in respiratory outcomes, suggesting potential benefits for patients with the most severe forms of COVID-19.
A case series describes the treatment and outcomes of heart transplant recipients infected with COVID-19 in New York City. The study reveals varying characteristics among patients, highlighting the need for individualized care.
A study examining factors affecting racial disparities before kidney transplantation found that socioeconomic status and comorbidities explain up to 58% of the disparity in listing. Black patients with kidney failure are more likely to be waitlisted than white patients, despite similar rates of transplant receipt.
A new study from the University of Copenhagen suggests that transplanted intestinal contents could be effective against obesity and type 2 diabetes. Researchers found that obese mice with unhealthy lifestyles gained significantly less weight and avoided type 2 diabetes when they received viruses transplanted from the stool of lean mice.
Researchers found fecal microbial transplantation reduced bloodstream infections and improved patient quality of life in chronically ill patients. FMT decolonized multi-drug resistant bacteria, allowing patients to undergo stem-cell transplants and return to work.
Researchers have developed a non-invasive method to visualize damage in donor kidneys using photoacoustic imaging. This technique allows for accurate assessment of kidney scarring and can potentially revolutionize transplantation protocol by matching organs with patient life expectancy, reducing costs and improving outcomes.
A 30-year study on Crigler-Najjar syndrome reveals the clinical course of 28 individuals with high bilirubin levels, demonstrating the effectiveness of phototherapy and liver transplantation. Early intervention is critical, and treatment delays increase brain damage risk.
A study by Kanatsu-Shinohara et al. shows that spermatogonial stem cell transplantation can restore sperm development in infertile mice, offering potential treatment for male infertility. The research uses chemically castrated mice with a Cldn11 gene deficiency.
A study of Southeastern US patients found that living far from a transplant center did not affect referral and evaluation initiation. Key findings indicate that other factors like travel time or transportation options may have a larger impact.
Fecal Microbiota Transplants (FMT) have shown high success rates in treating C.diff infection, with 78% of patients experiencing no recurrence of diarrhoea within 90 days. This treatment is particularly effective compared to antibiotics, which have lower success rates for relapsing infections.
The study reveals a significant increase in survival rates after liver transplantation in the UK, with improvements seen in both short-time and long-term outcomes. The advancements are attributed to better surgical techniques and immunosuppression strategies.
Survival rates have improved significantly for children who received kidney transplants, with a 72% lower mortality risk among those transplanted later than earlier periods. This improvement is primarily attributed to reduced deaths from cardiovascular causes and infections.
Recent publications provide insights into FMT research, emphasizing the need for rigorous clinical trials to demonstrate safety and effectiveness. Researchers are evaluating different preparations of FMT and manufacturers are developing products for licensure.
Researchers at the University of Cincinnati are using APOL1 genotyping to identify high-risk African American donors and reduce their chances of developing kidney disease. The study aims to optimize the health of organ donors by protecting them from genetic factors that increase their risk of kidney disease.
A 30-year study details clinical course of 184 individuals with genetically diverse forms of MSUD, showing increased survival and hospitalization rates. Despite advances in care, patients continue to suffer from cognitive and psychiatric disabilities, highlighting the need for safer and more effective disease-modifying interventions.
Researchers develop machine that repairs injured human livers and keeps them alive for a week outside the body. The technology increases the number of available organs for transplantation, saving lives of patients with severe liver diseases or cancer.
A new study found that higher adherence to the Mediterranean diet is associated with a lower risk of kidney function decline and failure in transplant recipients. Those with higher Mediterranean Diet Scores experienced 29% less risk of function loss and 32% less risk of failure.
A case series of 80 heart transplant patients reveals that donors positive for hepatitis C pose a risk to recipients, who developed chronic liver disease and cirrhosis.
A new study published in Blood Advances found that patients receiving multidisciplinary, holistic evaluation before undergoing transplantation have improved outcomes and survival rates. The team-based approach coordinated recommendations from various care providers and created individualized treatment plans.
A recent study found that mitochondrial damage-associated molecular patterns (mtDAMPs) are released by DCD hearts following warm ischemia, correlating with subsequent contractile recovery. The research team aims to investigate the role of mtDAMPs in inflammatory responses and recovery of contractile function in cardiac grafts.
Researchers found budesonide reduced serious side effects like new onset diabetes and bone loss in liver transplant patients, while maintaining comparable organ rejection rates to prednisone. The study involved 20 patients and showed lower infection rates and improved blood sugar control.