Articles tagged with Transplantation
A new study reveals that fecal microbiota transplants can increase Lachnospiraceae bacteria, which outcompete C. diff for resources and alter bile acids to create an environment favorable for other good bacteria to thrive.
Researchers have made breakthroughs in creating nanoparticles that can modify the immune system to accept transplanted organs without compromising it. This new approach has potential implications for treating diabetes, cell therapy, and autoimmune disorders, offering hope for patients who currently face rejection.
The study reports an overall 5- and 10-year survival of face transplants at 85% and 74%, respectively, making them a viable option for patients with severe facial defects. The majority of these complex cases are typically treated with conventional methods.
A study published in JAMA reports on the eye's functioning after a whole-eye transplant, revealing normal pressure and blood flow over time. The transplanted eye has maintained some remaining structure in the retina, offering hope for future sight restoration.
The world's first combined whole eye and face transplant has demonstrated allograft survival, including rejection-free graft survival. The transplanted eye has maintained normal pressure, good blood flow, and some remaining structure and functions in the retina. Researchers are now focused on understanding how to restore sight.
Women with hepatocellular carcinoma are less likely to receive a deceased-donor liver transplant due to sex-based differences in candidate size. The study's findings highlight the need for changes in allocation policy to improve access to size-matched donor livers for smaller candidates.
A new study by NYU Langone Health found that the risk of death for kidney donors has decreased significantly since the 1990s, with fewer than one death occurring for every 10,000 donations. Donors who were male and had a history of high blood pressure were more likely to die within 90 days of surgery.
The Northwestern University Transplant Access Program (AATAP) has supported nearly 300 patients, with over 50 receiving a kidney or liver transplant. The program focuses on the needs of Black Americans, addressing structural and institutional barriers to access.
Researchers at the University of Gothenburg found that hearts stored in a 'heart-in-a-box' method experienced lower rates of heart failure and severe organ failure after transplantation. This breakthrough method uses hypothermic oxygenated machine perfusion to keep the heart oxygenated and functioning better.
A uterus transplant was successfully performed on women with absolute uterine-factor infertility, resulting in a high live birth rate. However, the procedure was also associated with significant medical and surgical risks for both recipients and donors.
A study published in JAMA Surgery shows that liver transplants significantly improve progression-free survival rates for patients with unresectable colorectal liver metastases compared to other therapies. At three years, 90% of transplant patients remained cancer-progression free, whereas only 42% of those receiving alternative treatme...
Researchers found that fecal microbiota transplantation did not offer significant improvements in motor and non-motor symptoms of Parkinson's disease. Further studies on modified approaches or bowel cleansing are needed to better understand the impact of donor microbiota composition.
A novel strategy using venetoclax and azacitidine demonstrates significant anti-cancer effect with mild toxicity for relapsed/refractory AML patients. The treatment showed markedly better survival rates after one year compared to a control group, with improved 'graft-versus-leukemia effects' via alterations of immune cells.
A new editorial paper discusses molecular and cytogenetic analyses used to identify distinct subtypes of acute myeloid leukemias (AML) and myelodysplastic syndromes (MDS). Researchers found that around 15% of AML cases remain genetically unclassifiable, emphasizing the need for further research.
A study found that pay-for-performance incentives increased home dialysis use and kidney transplant rates. The End-Stage Renal Disease Treatment Choices model did not associate these outcomes with changes in racial or socioeconomic disparities.
A large international study of 1,042 living kidney donors found no significant differences in health indicators compared to non-donors seven years after donation. The study also provides insights into recovery time from living kidney donation, suggesting a longer recovery period than previously thought.
Primary sclerosing cholangitis increases risk of bile duct cancer; early diagnosis is essential for successful treatment with liver transplantation. Regular MRI/MRCP scans are critical for early detection and may be recommended for high-risk PSC patients.
Researchers from Nagoya University have successfully treated rare genetic skin disorders epidermolytic ichthyosis (EI) and ichthyosis with confetti (IWC) by transplanting genetically healthy skin to inflamed areas. Transplantation of healthy skin has been used as a treatment option for severe burn injuries.
Scientists from Tokyo Medical and Dental University successfully generate autologous skin grafts by introducing mutations into mouse embryos, which then form sheets of epidermis containing hair follicles. These grafted skin patches survive up to 3 months and mimic mature epidermis structure.
A recent study by Dr. Zhaohua Jiang successfully demonstrated VLNT's effectiveness in reconnecting the lymphatic system and improving patient outcomes. The procedure involves transplanting healthy lymph nodes into the affected area, promoting regeneration and reconnection of lymphatic vessels.
Receiving a kidney from a deceased donor who underwent dialysis prior to donation was associated with delayed graft function, while other factors such as graft failure and death were not significantly affected. The study found no significant differences in outcomes between these two groups.
Researchers at Clemson University have developed a simulation-based optimization approach to overcome challenges in vitrification of larger tissues. The new technology results in high viability rates for vitreous grafts, making them suitable for transplantation.
A study published in JAMA found that Black candidates have lower heart offer acceptance rates compared to white candidates of the same gender, while women have higher acceptance rates than men. These disparities persist after adjusting for various factors, highlighting the need for further investigation into site-level decision-making.
A multi-institutional team is creating innovative technologies to reduce complications associated with left ventricular assist devices (LVADs), including infection, thrombosis, stroke, and bleeding. The new LVAD will deliver a physiological response to changes in the recipient's activity levels using a 'smart' Maglev drive technology.
A novel risk score predicts cardiovascular complications after bone marrow transplant with high accuracy, helping guide patient selection and post-transplant management. Patients with preexisting cardiovascular conditions are more likely to experience long-term complications.
A new study found that dialysis facilities serving high-risk populations are more likely to receive lower reimbursement under the End-Stage Renal Disease Treatment Choices Model. The rate of home dialysis and transplant waitlisting is also lower among these facilities.
Researchers found that pulse oximeters underestimate blood pumping and overestimate resistance, affecting treatment decisions. Direct blood oxygen measurement is crucial for accurate guidance, especially for Black patients already at higher risk.
Segregated neighborhoods contribute to racial disparities in live donor kidney transplantation. Targeted interventions, such as community outreach clinics, can help mitigate these effects and promote equitable access.
A team of researchers from Texas Heart Institute and Baylor College of Medicine have made a significant discovery about the underlying molecular cell states within transplanted pediatric hearts. They found that donor-derived tissue-resident macrophages are crucial for graft acceptance, but their loss leads to allograft failure.
A study suggests that a pain relief drug can quickly and reversibly induce a sleep-like state in cells and organs, facilitating organ transplantation and preventing irreversible tissue injury. The research found that the drug SNC80 can slow biochemical and metabolic activities while preserving cell and tissue viability.
UCLA surgeons and scientists present research on ethnic predictors of gastric cancer survival, early liver retransplantation and risk factors for chemical restraint use in adult trauma patients. The studies highlight the importance of understanding these factors to improve patient care.
Researchers found combining common immune-suppressing drugs with a complement inhibitor effectively managed the initial human immune response against transplanted pig kidneys. The regimen, which relies solely on already FDA-approved medications, showed remarkable success in Parsons model case series.
Researchers at UMCG have successfully performed liver transplants after prolonged preservation using a perfusion machine, showing similar outcomes to immediate transplants. The new method allows for safer and more efficient liver transplantation during the day, reducing complications and mortality rates.
Researchers found that specific microbes in the gut reduce graft versus host disease after stem cell transplantation. Patients with low microbial metabolite risk index had better survival rates, fewer graft vs. host reactions, and reduced relapses.
Researchers found that higher levels of omega-3 fatty acids in the blood plasma were associated with better lung function and longer survival without needing a lung transplant. This was consistent regardless of smoking history or cardiovascular disease.
A Learning Health System model is being developed to increase organ donation and reduce disparities in access to transplantation. The project, led by Hennepin Healthcare Research Institute, will use data tools to track progress and improve equity in organ donation across the US.
Researchers from Brazil discuss the management of refractory or relapsed classic Hodgkin lymphoma in adults, highlighting novel agents such as brentuximab vedotin and immunotherapy. The Brazilian healthcare system's constraints are also considered when making treatment decisions.
A study of 57,000 adults reveals racial disparities in access to living donor kidney transplants, highlighting the need for targeted interventions. The findings emphasize the importance of addressing systemic inequalities in transplant programs and centers.
A new study provides an updated assessment of hepatorenal syndrome-acute kidney injury (HRS-AKI), a potentially reversible but often fatal condition. The study's findings highlight the importance of early recognition and standard pharmacological treatment, with only 40%–50% of patients experiencing restored kidney function.
Researchers transplanted gut microbes from a naturally obesity-resistant shrew to high-fat-diet-induced obese mice, improving microbiome diversity. This approach resulted in decreased weight gain in the obese mice, suggesting potential therapeutic benefits for human obesity.
A novel multicomponent intervention aimed at improving patient access to kidney transplants did not significantly increase the rate of completed steps in a randomized clinical trial involving 20,375 patients. The study highlights the need for sustained efforts to address barriers to transplantation globally.
Scientists from Central South University develop a novel approach to address bacterial infection in bone transplantation by enriching H2O2 and amplifying the Fenton reaction. The technique enhances biocompatibility and safety, promising reduced transplant failures and post-operative complications.
Researchers at the University of Birmingham found that individuals with fatty liver disease are three times more likely to have a personality disorder than those without. Lifestyle modifications, such as changes in diet and exercise, can prevent disease progression but often fail to be implemented due to mental health factors.
Scientists have discovered a suitable combination of chemical compounds that can preserve adult zebrafish hearts for up to 5 days at -10°C. This breakthrough could potentially be used for the preservation of other organs before transplantation, revolutionizing organ donation and increasing the chances of successful transplants.
A new study found that living donor liver transplant access optimizes the timing of transplant for older, frail cirrhosis patients. Patients with moderate to severe frailty, short stature, and low MELD scores benefited from LDLT, reducing waitlist mortality and improving post-transplant outcomes.
A team of researchers identified a protein called RAC2 that appears to drive the foreign body response, which causes the body to reject biomedical implants. Suppressing production of this protein could reduce the risk of implant rejection and improve the design and safety of implants.
A recent study published in the American Journal of Kidney Diseases found that lower uromodulin levels are associated with a higher risk of developing end-stage kidney disease. Participants who experienced steeper declines in uromodulin also showed an increased risk of kidney failure.
Researchers at UW–Madison and Stanford University developed a new approach to increase donor and recipient biocompatibility, inducing tolerance in transplanted kidneys. Two monkeys with just one match among key protein strings maintained chimeric immune systems for over four years without rejection or graft-versus-host disease.
A new device developed by Northwestern University researchers can detect temperature irregularities associated with inflammation and other body responses that arise with transplant rejection. This allows for earlier intervention, improving patient outcomes and increasing the odds of preserving donated organs.
Researchers at Duke University Medical Center developed a new monoclonal antibody that successfully prevented organ rejection in primates undergoing kidney and islet transplantations. The findings suggest a safer alternative to existing immunosuppressive drugs, reducing side effects and improving graft survival rates.
A new matching system enabled by Boston College economists facilitates the world's first four-way liver exchange and a cascade of additional matches. The system increases the number of transplants that can be matched among a larger group of participants, expanding capacity beyond traditional two-way exchanges.
Researchers have found that mouse stem cells mimic their parent animals' cold resistance, generating energy differently at low temperatures. This discovery opens up new avenues for studying organ preservation and human hibernation using in vitro models.
Hematopoietic stem cell culture technology improves genome editing in HSCs by increasing successful correction rates to 100%, eliminating genetic mutations, and enhancing cell transplantation outcomes. This breakthrough enhances the efficiency and safety of gene editing in treating genetic diseases.
This study demonstrates the potential of cell therapy using genome-edited iPS cells secreting therapeutic molecules, such as mNAGA, to supply GLA activity in vivo. Transplantation of these cells improved GLA activity in the liver, but not in other organs, and future enhancements are possible through genome editing.
A new AI tool utilizing deep-learning algorithms and volumetric thresholds accurately detected splenomegaly in patients undergoing CT scans. The study analyzed a large sample of 8,901 patients, revealing that splenic volume is strongly associated with weight.
Researchers investigated premature senescence in biliary atresia and assessed senotherapies. They found that human allogenic liver-derived progenitor cells reduced early markers of senescence and improved liver disease in a preclinical model, providing encouraging results for pediatric biliary cirrhosis treatment.
The new scientific statement highlights the importance of identifying the root cause of pediatric cardiomyopathy to develop effective treatment strategies. Genetic testing is recommended for all children with cardiomyopathy, which may lead to financial and emotional cost savings.
Survivors of firearm injury experience chronic PTSD symptoms and poor health-related quality of life, emphasizing the need for comprehensive care. Screening for chronic kidney disease could be cost-effective for US adults starting at age 35.
A study found that heart transplant patients receiving organs from active COVID-19 positive donors had increased risk of death at six months and one year compared to those receiving organs from recently recovered COVID-19 patients and COVID-19 negative patients.
A UNIGE team has developed small beads encapsulating fecal bacteria for treating a serious intestinal infection. The technology overcomes obstacles in current treatments, allowing for easier and more comfortable administration.