Articles tagged with Transplantation
Hepatocellular carcinoma is the most prevalent form of liver cancer, and liver transplantation offers a curative treatment option for appropriately selected patients. Bridging therapies, such as radiofrequency ablation and transarterial chemoembolization, can improve survival outcomes post-transplant by preventing tumor progression.
A groundbreaking study transplants 384 m² of Posidonia oceanica to preserve Mediterranean ecosystems threatened by coastal development. The method successfully preserves roots and substrate, leading to remarkable resilience and expansion.
An international team of scientists has molecularly decoded blood stem cell differentiation pathways using state-of-the-art sequencing methods. They identified a crucial surface protein, PD-L2, which suppresses the immune response by preventing T cell activation and release of inflammatory substances.
The International Society for Health and Lung Transplantation (ISHLT) has re-launched the Global IMACS Registry to collect data on patients with durable mechanical circulatory support devices. The registry aims to advance MCS therapy and improve patient outcomes globally.
A new nanotechnology-based drug delivery system has been developed to save patients from repeated surgeries. The approach, called Pericelle, uses a paste of nanoparticles containing hydrogel on transplanted veins to prevent blockages, which can lead to repeated surgeries in heart and dialysis patients.
A new trial will test whether taking HMB can improve patients' physical function and quality of life. The BOOST study aims to recruit 124 patients with cirrhosis and measure its effects on liver disease, mental wellbeing, and physical function over 24 weeks.
A study published in ERJ Open Research found that women are less likely to receive a lung transplant and wait an average of six weeks longer for one. Despite this, women who undergo transplantation have higher survival rates five years post-transplant.
Researchers discovered a novel combination of plasma-based biomarkers that can predict liver fibrosis in Latino adolescents with obesity. The study found that dihydroxyacetone phosphate (DHAP) and alanine transaminase (ALT) were significantly associated with fibrosis, suggesting a potential low-cost, noninvasive screening tool.
Researchers at Osaka Metropolitan University developed a new technique for head and neck reconstruction that achieves 100% success rate in high-risk patients. The pedicled latissimus dorsi flap technique provides a reliable, fast, and minimally invasive option for complex tissue defects.
Researchers developed a deep-learning model to predict organoid development at an early stage, outperforming human experts in accuracy and speed. The model classifies bright-field images of organoids into three quality categories, indicating their potential for regenerative medicine applications.
Researchers identified plasma extracellular vesicle-derived microRNAs as potential biomarkers for AATD liver disease. They found 39 differentially expressed miRNAs, which were validated in an independent cohort for predicting AATD liver disease.
The Emory University Hospital team successfully implanted the BrioVAD System, a novel magnetically levitated pump designed for patient ease and long-term health. This marks the first-time use of the device in the US, as part of the INNOVATE clinical trial.
The updated Model for End-Stage Liver Disease (MELD) 3.0 has reduced liver transplant disparities for women, increasing their chances of being added to the waitlist, receiving a transplant, and staying on it. Women now have equalized rates with men in terms of waitlist mortality and transplant rates after the policy change.
Researchers used Intermountain Risk Score to predict major cardiac events in patients being evaluated for kidney transplant, with a five-year follow-up period showing 171 patients experiencing cardiac events. The study's findings suggest the potential use of calculating such a score in people undergoing kidney transplant evaluation.
New research suggests that adopting the UK's three-hour organ donation rule could significantly increase kidney transplants globally. This change could lead to an additional 1,000 kidney transplants in the US per year and improve patient outcomes.
Hospitalization rates for alcohol-induced liver disease rose significantly between 2005 and 2021, with greater absolute increases among older males than younger females. The study highlights the growing burden of this condition and underscores the importance of addressing alcohol-related liver disease.
New research at Lund University reveals that heart transplant patients often suffer from long-term pain and symptom distress after the procedure. However, with simple support in symptom management, patients can regain control over their life and feel more competent, active, and confident. The study found that a person-centred approach,...
A new AI-powered model has been developed to predict kidney transplant outcomes with high accuracy, offering hope for more efficient organ allocation and improved patient outcomes. The tool, UK-DTOP, outperforms existing methods in predicting outcomes for deceased-donor kidney transplants.
A multicenter observational study in the US found that kidney transplantation from deceased donors with HIV to recipients with HIV was safe and noninferior to transplantation from donors without HIV. The study enrolled 198 adults with HIV and end-stage kidney disease, comparing outcomes between 99 donors with HIV and 99 without.
A new study found that kidney transplantation from HIV-positive donors to recipients with HIV is safe and effective, with comparable survival rates and risks of serious side effects. The study's results support the use of organs from HIV-positive donors as standard clinical practice for people with HIV in need of kidney transplantation.
A new study reveals that fecal microbiota transplants can increase Lachnospiraceae bacteria, which outcompete C. diff for resources and alter bile acids to create an environment favorable for other good bacteria to thrive.
Researchers have made breakthroughs in creating nanoparticles that can modify the immune system to accept transplanted organs without compromising it. This new approach has potential implications for treating diabetes, cell therapy, and autoimmune disorders, offering hope for patients who currently face rejection.
The study reports an overall 5- and 10-year survival of face transplants at 85% and 74%, respectively, making them a viable option for patients with severe facial defects. The majority of these complex cases are typically treated with conventional methods.
The world's first combined whole eye and face transplant has demonstrated allograft survival, including rejection-free graft survival. The transplanted eye has maintained normal pressure, good blood flow, and some remaining structure and functions in the retina. Researchers are now focused on understanding how to restore sight.
A study published in JAMA reports on the eye's functioning after a whole-eye transplant, revealing normal pressure and blood flow over time. The transplanted eye has maintained some remaining structure in the retina, offering hope for future sight restoration.
Women with hepatocellular carcinoma are less likely to receive a deceased-donor liver transplant due to sex-based differences in candidate size. The study's findings highlight the need for changes in allocation policy to improve access to size-matched donor livers for smaller candidates.
A new study by NYU Langone Health found that the risk of death for kidney donors has decreased significantly since the 1990s, with fewer than one death occurring for every 10,000 donations. Donors who were male and had a history of high blood pressure were more likely to die within 90 days of surgery.
The Northwestern University Transplant Access Program (AATAP) has supported nearly 300 patients, with over 50 receiving a kidney or liver transplant. The program focuses on the needs of Black Americans, addressing structural and institutional barriers to access.
Researchers at the University of Gothenburg found that hearts stored in a 'heart-in-a-box' method experienced lower rates of heart failure and severe organ failure after transplantation. This breakthrough method uses hypothermic oxygenated machine perfusion to keep the heart oxygenated and functioning better.
A uterus transplant was successfully performed on women with absolute uterine-factor infertility, resulting in a high live birth rate. However, the procedure was also associated with significant medical and surgical risks for both recipients and donors.
A study published in JAMA Surgery shows that liver transplants significantly improve progression-free survival rates for patients with unresectable colorectal liver metastases compared to other therapies. At three years, 90% of transplant patients remained cancer-progression free, whereas only 42% of those receiving alternative treatme...
Researchers found that fecal microbiota transplantation did not offer significant improvements in motor and non-motor symptoms of Parkinson's disease. Further studies on modified approaches or bowel cleansing are needed to better understand the impact of donor microbiota composition.
A novel strategy using venetoclax and azacitidine demonstrates significant anti-cancer effect with mild toxicity for relapsed/refractory AML patients. The treatment showed markedly better survival rates after one year compared to a control group, with improved 'graft-versus-leukemia effects' via alterations of immune cells.
A new editorial paper discusses molecular and cytogenetic analyses used to identify distinct subtypes of acute myeloid leukemias (AML) and myelodysplastic syndromes (MDS). Researchers found that around 15% of AML cases remain genetically unclassifiable, emphasizing the need for further research.
A study found that pay-for-performance incentives increased home dialysis use and kidney transplant rates. The End-Stage Renal Disease Treatment Choices model did not associate these outcomes with changes in racial or socioeconomic disparities.
Primary sclerosing cholangitis increases risk of bile duct cancer; early diagnosis is essential for successful treatment with liver transplantation. Regular MRI/MRCP scans are critical for early detection and may be recommended for high-risk PSC patients.
A large international study of 1,042 living kidney donors found no significant differences in health indicators compared to non-donors seven years after donation. The study also provides insights into recovery time from living kidney donation, suggesting a longer recovery period than previously thought.
Researchers from Nagoya University have successfully treated rare genetic skin disorders epidermolytic ichthyosis (EI) and ichthyosis with confetti (IWC) by transplanting genetically healthy skin to inflamed areas. Transplantation of healthy skin has been used as a treatment option for severe burn injuries.
Scientists from Tokyo Medical and Dental University successfully generate autologous skin grafts by introducing mutations into mouse embryos, which then form sheets of epidermis containing hair follicles. These grafted skin patches survive up to 3 months and mimic mature epidermis structure.
A recent study by Dr. Zhaohua Jiang successfully demonstrated VLNT's effectiveness in reconnecting the lymphatic system and improving patient outcomes. The procedure involves transplanting healthy lymph nodes into the affected area, promoting regeneration and reconnection of lymphatic vessels.
Receiving a kidney from a deceased donor who underwent dialysis prior to donation was associated with delayed graft function, while other factors such as graft failure and death were not significantly affected. The study found no significant differences in outcomes between these two groups.
Researchers at Clemson University have developed a simulation-based optimization approach to overcome challenges in vitrification of larger tissues. The new technology results in high viability rates for vitreous grafts, making them suitable for transplantation.
A study published in JAMA found that Black candidates have lower heart offer acceptance rates compared to white candidates of the same gender, while women have higher acceptance rates than men. These disparities persist after adjusting for various factors, highlighting the need for further investigation into site-level decision-making.
A multi-institutional team is creating innovative technologies to reduce complications associated with left ventricular assist devices (LVADs), including infection, thrombosis, stroke, and bleeding. The new LVAD will deliver a physiological response to changes in the recipient's activity levels using a 'smart' Maglev drive technology.
A novel risk score predicts cardiovascular complications after bone marrow transplant with high accuracy, helping guide patient selection and post-transplant management. Patients with preexisting cardiovascular conditions are more likely to experience long-term complications.
A new study found that dialysis facilities serving high-risk populations are more likely to receive lower reimbursement under the End-Stage Renal Disease Treatment Choices Model. The rate of home dialysis and transplant waitlisting is also lower among these facilities.
Researchers found that pulse oximeters underestimate blood pumping and overestimate resistance, affecting treatment decisions. Direct blood oxygen measurement is crucial for accurate guidance, especially for Black patients already at higher risk.
Segregated neighborhoods contribute to racial disparities in live donor kidney transplantation. Targeted interventions, such as community outreach clinics, can help mitigate these effects and promote equitable access.
A team of researchers from Texas Heart Institute and Baylor College of Medicine have made a significant discovery about the underlying molecular cell states within transplanted pediatric hearts. They found that donor-derived tissue-resident macrophages are crucial for graft acceptance, but their loss leads to allograft failure.
A study suggests that a pain relief drug can quickly and reversibly induce a sleep-like state in cells and organs, facilitating organ transplantation and preventing irreversible tissue injury. The research found that the drug SNC80 can slow biochemical and metabolic activities while preserving cell and tissue viability.
Researchers found combining common immune-suppressing drugs with a complement inhibitor effectively managed the initial human immune response against transplanted pig kidneys. The regimen, which relies solely on already FDA-approved medications, showed remarkable success in Parsons model case series.
UCLA surgeons and scientists present research on ethnic predictors of gastric cancer survival, early liver retransplantation and risk factors for chemical restraint use in adult trauma patients. The studies highlight the importance of understanding these factors to improve patient care.
Researchers at UMCG have successfully performed liver transplants after prolonged preservation using a perfusion machine, showing similar outcomes to immediate transplants. The new method allows for safer and more efficient liver transplantation during the day, reducing complications and mortality rates.
Researchers found that specific microbes in the gut reduce graft versus host disease after stem cell transplantation. Patients with low microbial metabolite risk index had better survival rates, fewer graft vs. host reactions, and reduced relapses.
Researchers found that higher levels of omega-3 fatty acids in the blood plasma were associated with better lung function and longer survival without needing a lung transplant. This was consistent regardless of smoking history or cardiovascular disease.
A Learning Health System model is being developed to increase organ donation and reduce disparities in access to transplantation. The project, led by Hennepin Healthcare Research Institute, will use data tools to track progress and improve equity in organ donation across the US.
Researchers from Brazil discuss the management of refractory or relapsed classic Hodgkin lymphoma in adults, highlighting novel agents such as brentuximab vedotin and immunotherapy. The Brazilian healthcare system's constraints are also considered when making treatment decisions.
A study of 57,000 adults reveals racial disparities in access to living donor kidney transplants, highlighting the need for targeted interventions. The findings emphasize the importance of addressing systemic inequalities in transplant programs and centers.
A new study provides an updated assessment of hepatorenal syndrome-acute kidney injury (HRS-AKI), a potentially reversible but often fatal condition. The study's findings highlight the importance of early recognition and standard pharmacological treatment, with only 40%–50% of patients experiencing restored kidney function.
Researchers transplanted gut microbes from a naturally obesity-resistant shrew to high-fat-diet-induced obese mice, improving microbiome diversity. This approach resulted in decreased weight gain in the obese mice, suggesting potential therapeutic benefits for human obesity.