Articles tagged with Transplantation
A new study conducted by researchers from Aarhus University and Aarhus University Hospital shows that fecal transplantation is an effective cure for life-threatening intestinal infections, with a cure rate of over 90%. The treatment was found to be far superior to the standard treatment, which typically consists of antibiotics.
Researchers found that using race-free creatinine formula helps equalize access for Black and white patients. The study showed that among 350 Black patients, kidney failure was reached at an average 23 months, versus an average 22 months for 122 white patients.
A recent study published in Clinical Nutrition found that sufficient protein intake is necessary to prevent sarcopenia after kidney transplantation. The research showed a positive correlation between changes in skeletal muscle mass and protein intake, with insufficient protein intake resulting in decreased muscle mass.
A team of EMBL researchers used data from over 300 human faecal microbiota transplants to investigate the ecological understanding of what happens when two gut microbiomes clash together. The study found that species richness and how different a recipient's gut microbiome is from a donor's are key factors in determining which microorga...
A new treatment may enable the use of a larger part of donated lungs, leading to improved outcomes and reduced complications. Researchers are conducting a clinical pilot study to investigate the effects of reducing cytokine levels in donor lungs.
Research finds that liver transplant recipients with a BMI of 30 or higher and those who drank heavily have a high risk of needing a second surgery within 48 hours. Coagulopathy, or decreased blood clotting, is also linked to this risk. The study aims to reduce the number of return-to-operating-room cases by mitigating these factors.
A group of researchers from Osaka Metropolitan University found that administering parathyroid hormone to rat Achilles tendons increased the production of cartilaginous matrix and promoted chondrogenic differentiation. This breakthrough discovery may lead to improved outcomes for meniscal reconstruction surgery, protecting knee cartila...
Bone marrow donors can now receive significantly reduced opioid medication during and after the donation procedure, resulting in a more comfortable experience. The new pain control method, using regional anesthesia, drastically decreased opioid usage from 84% to 23% among patients.
The study reveals uterus transplant outcomes are safe for the recipient, living donor, and child, making it a potential solution for women struggling with uterine-factor infertility. Uterus transplants may be a viable option for these individuals, offering a chance to conceive and carry a pregnancy.
A team proposes banking stool samples for future use in autologous fecal microbiota transplants to rejuvenate the human gut microbiome. This approach aims to treat various diseases, including asthma and type 2 diabetes, by restoring an ancestral state of the microbiome.
A study found that over 60% of parents of children with kidney disease or hypertension are unsure or unwilling to vaccinate their child against COVID-19. Effective vaccines exist to protect children from COVID-19, and the findings highlight the need for clear communication to address parental concerns.
The study found that uterine transplantation is an effective method to remedy infertility, with a clinical pregnancy rate of 33% and cumulative live birth rate exceeding expectations. The procedure also showed positive health outcomes, including improved quality of life and low rates of anxiety and depression.
Researchers found that a bridge therapy approach prior to consolidation therapy can improve event-free survival in patients with stable metastatic cancer after induction therapy. Patients who received this treatment had significantly better outcomes compared to those who underwent direct consolidation or post-induction therapy alone.
A new study from University of Minnesota Medical School suggests Fecal Microbiota Transplantation (FMT) is an optimal and cost-effective treatment option for the first recurrent Clostridioides difficile infection. The research model indicates it's effective and cost-effective when used in patients after a single episode of recurrent CDI.
A large randomized controlled trial found that treatment with methylprednisolone reduces the risk of kidney function loss and failure in patients with IgA nephropathy. The study's results suggest a lower dose regimen may be effective while minimizing side effects.
Scientists have found that transplanting faecal microbiota from young mice into old mice can reverse hallmarks of ageing in the gut, eyes, and brain. The study suggests that gut microbes play a role in regulating some of the detrimental effects of ageing, offering a potential solution in the form of gut microbe replacement therapy.
State bans on affirmative action policies are associated with lower enrollment of underrepresented minority students in public medical schools. The study found a 5.5 percentage point decrease in enrollment of underrepresented students relative to control schools.
A recent study found that COVID-19 vaccination significantly reduces the risk of infection, hospitalization, and death among heart transplant recipients. The study, published in JAMA Cardiology, compared vaccinated and unvaccinated patients at a single center and showed a notable difference in outcomes.
A new study by the Mayo Clinic confirms that living kidney donor surgery via laparoscopic surgery is low-risk for most patients, with only 2.5% experiencing major complications. The study tracked over 3,000 donors and found that most complications occurred after discharge.
Patients with mild to moderate kidney disease and kidney transplant recipients had a higher risk of cancer. They also faced a higher risk of dying from cancer, particularly from cancers such as bladder, kidney, and multiple myeloma, compared to those with normal kidney function.
Dialysis facilities referred more incident patients, transplant centers evaluated more, but fewer were placed on the waitlist following KAS implementation. This led to a decline in overall waitlisting nationwide.
A cost-effectiveness analysis found that adherence promotion programs like MAPS reduce costs and improve outcomes for adolescent kidney transplant recipients. Strategies with similar costs to MAPS can still be cost-effective if they decrease rejection episodes by a small amount.
Young adults are disproportionately excluded from kidney transplantation, with only 1.8% of Black and 4.4% of Hispanic patients receiving the treatment compared to 10.9% of White patients within this age group. The study highlights the need for targeted interventions to address these disparities.
Scientists have discovered families of proteins that can predict liver transplant rejection, allowing for early detection and modification of immunosuppression. The Blood Proteoform Atlas outlines over 56,000 protein molecules associated with immune cell proteins that change with rejection.
A recent study has investigated the effect of donor selection on transplanted microbiota establishment and long-term stability in aged hosts. Autologous FMT demonstrated better resilience than heterologous FMT in restoring gut microbiota diversity after antibiotic-induced perturbation.
A recent study published in Science Translational Medicine identified a novel causative gene, BAG5, for dilated cardiomyopathy, a leading cause of heart failure. The researchers found that mutations in this gene can lead to cardiomyopathy and found a potential treatment alternative using adeno-associated viruses (AAV) gene therapy.
A new graft strategy has reduced chronic graft-versus-host disease in leukemia patients by depleting naïve T cells from donor blood. The approach has shown promising results, with only 7% of patients developing chronic GVHD compared to 30-60% with standard treatment.
A case series found that a fourth dose of an mRNA-based vaccine increases antispike IgG titers in kidney transplant recipients with weak serologic response after three doses. The researchers noted no safety concerns with the additional dose and suggested its use for such patients.
Researchers developed a new SERS-based multiplexing technique to detect kidney injury biomarkers SLPI and IL-18, achieving high sensitivity and reliability. The approach shows promise for objectively assessing donor kidney quality, potentially reducing discard rates and recipient complications in clinical practice.
The THINKER-NEXT trial will transplant 200 kidneys from HCV-positive donors into new patients to assess long-term outcomes and risks. The study aims to increase adoption of this practice nationwide and provide hope for those waiting on the kidney transplant list.
A new method measures glomerular filtration rate using D-serine clearance, showing strong correlation with GFR and lower bias than creatinine clearance. This could improve clinical practice and reduce dialysis patients.
A qualitative study of seven women who underwent uterine transplantation found that they experienced a mix of emotions, including anxiety and sense of unreality. The women reported feeling like most other mothers, but also struggled with the medical supervision and feelings of uncertainty.
Research using ring-tailed lemurs shows that fecal microbiota transplants can stabilize and restore a healthy gut microbiome after antibiotic use. The study confirms the effectiveness of this ancient treatment for reducing the negative effects of antibiotics on the gut, which can cause severe diarrhea and abdominal pain.
Researchers observed a significant increase in waiting list registrations and deceased donor liver transplants for alcoholic hepatitis during the COVID-19 pandemic. This spike in demand may indicate a relationship between increasing alcohol sales and misuse during the pandemic, with trends for other conditions remaining unchanged.
A new study found that racial and ethnic disparities in pediatric kidney transplantation decreased significantly after the implementation of the Kidney Allocation System in 2014. The study showed no racial disparities in waitlist time until transplantation before or after the policy change, but disparities remained for time on dialysis...
A VCU study found that people with advanced liver scarring caused by obesity and diabetes are dying from liver disease, underscoring the need for new treatments. The research provides a roadmap for future therapies to prevent liver transplants and save lives.
A new protocol combining patient monitoring and monoclonal antibody therapy reduced hospitalizations by half and deaths to zero for eligible patients. The study, conducted at Keck Medicine of USC, shows improved outcomes among liver and kidney transplant recipients with COVID-19.
A new study found that the COVID-19 pandemic led to a 30% decline in patients seeking treatment for kidney failure, with Black patients experiencing significantly worse kidney function. The decline was attributed to changes in healthcare delivery and may reflect delays in treatment due to fear of infection or logistical barriers.
Research provides insights on immune responses of kidney transplant recipients following SARS-CoV-2 infection. The study found that production of IgG antibodies against the virus was delayed in these individuals, but their IgM and IgA responses were similar to those observed in non-transplant individuals.
A recent analysis found a large increase in deaths among susceptible individuals, including minorities, due to COVID-19. The study highlights the vulnerability of kidney transplant recipients and those with kidney failure to severe illness from the virus.
The study reveals that SARS-CoV-2 damages the kidneys by interacting with ACE2, leading to an imbalance in blood pressure regulation and inflammation. This can result in impaired kidney function, reduced glomerular filtration rate, and increased risk of acute renal injury.
Researchers propose reinstating waiting time for recipients experiencing early post-transplant allograft failure within an expanded timeframe to boost transplant numbers. This policy change could potentially reduce the perceived patient-level risk of transplanting marginal organs and improve organ utilization.
Nine out of ten patients with life-threatening diarrhoea can be cured by faecal microbiota transplantation, according to a European study. Denmark is at the forefront of introducing this treatment, with 25% of eligible patients receiving it, compared to just 10% in other countries.
Researchers found that high levels of complement protein Ba are a reliable indicator of transplant-associated thrombotic microangiopathy development, contrary to previous reports. The study's findings provide hope for developing prophylactic treatments to prevent the disease.
Researchers found that hematopoietic cell transplantation (HCT) normalizes the gut microbiota of patients with IBD associated with XIAP deficiency. The study revealed that HCT decreases gut inflammation and restores diversity in gut microbiota, improving symptoms and quality of life for affected individuals.
Long-term kidney transplant survival rates in the US have increased significantly over the last three decades, with five-year survival rates for deceased and living donors rising from 66.2% and 79.5%, respectively, in 1996-1999 to 78.2% and 88.1% in 2012-2015.
A recent study investigated sex disparity in living donor liver transplant access, revealing a significant inequity between men and women. The research suggests that male donors have better access to liver transplants than female donors, highlighting the need for gender-specific solutions to address this disparity.
Ongoing acute kidney injury in deceased donor kidneys is linked to lower long-term graft survival. Notably, abnormal serum creatinine values during procurement also negatively impact graft outcomes.
The study analyzed patient data before and during the pandemic, revealing a significant increase in liver transplant requests and procedures. During the pandemic, more patients with acute alcohol-associated hepatitis underwent liver transplantation, highlighting the need for increased access to transplantation services.
A Rutgers study suggests that newborns at risk for Type 1 diabetes due to antibiotic exposure can have their condition reversed by receiving a maternal fecal transplant. The transplant restored key gut microorganisms and brought diabetes risk back to baseline levels.
Severe PES is characterized by high fever, rash, diarrhea, and increased transplant-related mortality. A study revealed that monocytes derived from cord blood produce proinflammatory cytokines, leading to PES. Tocilizumab treatment significantly controlled clinical symptoms and reduced mortality in patients with severe PES
A double-blind, randomized trial found that patients with severe obesity and metabolic syndrome had improved insulin sensitivity after receiving a fecal microbial transplant followed by daily fibre supplements. The study, led by Professor Karen Madsen, suggests that the microbiome can be targeted to improve human health.
A 15-year study on Guam's native cycad tree found that transplanted individuals have a high mortality rate when introduced to foreign soil, with less than 10% surviving long-term. The results highlight the importance of considering local adaptation for conservation efforts.
Researchers examined family voucher-based kidney donations and found that timely kidney transplants are possible through voucher redemption. The study aims to provide a new option for individuals waiting for a transplant, improving outcomes for those in need.
A new Northwestern Medicine study reveals persistent racial disparities in cirrhosis outcomes, with Black patients facing higher mortality rates and lower transplant approval rates. The findings underscore the need for targeted interventions to improve healthcare access for Black patients, who face structural and institutional barriers...
A double-blind trial found that faecal microbiota transplantation did not improve treatment outcomes or reduce symptoms in patients with active peripheral PsA. The study suggests that FMT may not be an effective treatment option for this condition, and future research is needed to explore its potential benefits.
Patients waiting for a kidney transplant who experienced various symptoms had a higher risk of dying while on the waitlist. However, those who underwent transplantation saw an improvement in symptoms, with overall 10% reduction and significant declines in fatigue and itchy skin.
A new study reveals that many patients with high-priority kidney transplants are not being placed on the transplant waiting list, despite having long expected post-transplant survival. African Americans, uninsured individuals, and those living in lower-income communities face significant barriers to expedited waitlist placement.
A new study published in the Journal of the American Geriatrics Society found that heart transplant surgery has a similar mortality rate for adults aged 18-69 and 70+, with only minor differences in stroke risk and donor hearts. Advanced age alone should not prevent people from being considered as candidates for heart transplants.
A new analysis found that post-heart transplant survival among older patients is on par with younger recipients. The study included 37,135 patients and showed a significant improvement in mortality rates after adjusting for other factors, suggesting that advanced age should not be a contraindication for heart transplantation.