Researchers have developed a defect-engineered metal-organic framework catalyst that converts glucose into lactic acid with substantially improved efficiency. The catalyst showed activity toward raw biomass feedstocks, producing a 62.8% lactic acid yield at 170°C after four hours when corn cobs were used directly as a biomass feedstock.
A Japanese registry study reveals widespread underdiagnosis and undertreatment of metabolic acidosis in chronic kidney disease patients. Nearly half of patients with bicarbonate measured had metabolic acidosis, and diagnosis and treatment rates were low, highlighting a need for routine bicarbonate testing in CKD care.
A new study examines the effect of rapid infusion of sodium bicarbonate on gas exchange and coronary and cerebral perfusion in the immediate post-resuscitation phase. The study found that rapid administration led to a significant rise in myocardial and cerebral perfusion, as well as higher levels of exhaled carbon dioxide.
Research suggests that inhaling carbon dioxide after a traumatic event makes fearful memories more resilient in mice. The study found that CO2 exposure strengthens fearful memories by activating ASIC1A protein in the brain. This discovery might lead to new therapeutic strategies for post-traumatic stress disorder (PTSD) in humans.
The UBI trial found that sodium bicarbonate treatment delayed progression of chronic kidney disease, reducing the risk of death by 57% and hospitalizations. The study also showed a significant delay in creatinine doubling time, translating to a relative risk reduction of 64%.
A new study found that TRC101, a hydrochloric acid binder, increased serum bicarbonate levels in patients with chronic kidney disease (CKD) and metabolic acidosis. The treatment was well-tolerated, with all adverse events being mild or moderate.
Researchers investigate alternatives to address ruminal acidosis, a serious disease affecting intensive farming systems. Feed additives, such as ionophores, can control lactic acid production, reducing the risk of acidosis and improving animal productivity.
A large prospective study has shown that a higher dietary acid load increases the risk of type 2 diabetes, regardless of individual foods. The study found that women with higher acid loads had a 56% increased risk of developing type 2 diabetes compared to those with lower acid loads.
Adding fruits and vegetables to the diet has been shown to reduce metabolic acidosis and kidney injury in late-stage chronic kidney disease patients. One-year plasma total carbon dioxide levels increased in both groups, indicating a lessening of metabolic acidosis.
Researchers present findings on zinc deficiency's role in allergic asthma, air pollution's significant health risk for patients with chronic lung diseases, and electrical stimulation as a potential bronchodilation treatment. Studies also explore the reduction of daily steroids in children with asthma and the association between high-do...
Reducing daily steroid doses for children with status asthmaticus shows no effect on hospital stay length. High-dose inhaled albuterol is linked to metabolic acidosis risk. Tonsil size may predict obstructive sleep apnea-hypopnea syndrome (OSAHS) in kids
Researchers monitor epithelial cell plasticity to understand its potential applications in tissue engineering and regenerative medicine. By analyzing individual cells, scientists can gain insights into how tissues adapt and respond to changing conditions.