Research on cancer as a disease, from cause to care. Covers tumor biology, small-cell lung cancer, cancer-linked stroke risk, and cancer center research.
Researchers have identified over 2,700 genes with unusual activity in people with scleroderma, a mysterious skin disease. The study's findings suggest the disease is systemic, not confined to visible skin patches, and may lead to improved diagnosis and targeted treatment options.
Researchers found that postmenopausal women who engaged in moderate-intensity exercise experienced significant reductions in weight, total body fat, and intra-abdominal fat. The study's large sample size and high adherence rates make it a significant finding for older women seeking to reduce their risk of chronic disease.
Researchers found that indomethacin reduced postoperative tumor growth by up to 63% in female and male rats. The study suggests controlling pain and inflammation may be crucial in managing cancer patients undergoing surgery.
A new study of 59 chronically ill children reveals that well-adjusted and supportive mothers are less likely to experience depression in their children. Children with stable caregiver relationships tend to cope better with chronic pain, suggesting early interventions for struggling caregivers could benefit the entire family.
A study of 77 twin pregnancies found that women who chose to continue their pregnancy despite a hydatidiform mole experienced a 40% chance of a successful outcome. This choice was associated with a relatively small chance of serious obstetric complications and did not increase the risk of developing malignant disease.
A study on twin pregnancies with a hydatidiform mole found that women who continue the pregnancy have a 40% chance of a successful outcome. The risk of serious obstetric complications is relatively small, and malignant disease does not appear to increase in this group
A new wireless imaging test has been developed to identify the source of gastrointestinal bleeding, enabling earlier treatment. The test, using a video capsule, was successful in diagnosing conditions not previously detected by conventional tests in 76% of cases.
A study of 271 patients with pheochromocytomas found that 24% carried one or more genetic mutations, including those in the VHL and RET genes. These mutations were associated with earlier symptom onset, multiple tumors, and specific tumor profiles.
Research suggests that defects in 'orphan' inositol polyphosphates may contribute to diseases such as manic depression and cancer. Dr. York's work identifies biological roles for these molecules and provides a basis for designing more specific drugs with fewer side effects.
Robert Eisenman, a leading oncogene expert, has made significant contributions to understanding how normal cells become cancerous and impacted studies of AIDS and other diseases. He will receive the award at the AACR annual meeting in San Francisco.
Researchers discovered a small molecular variation that inactivates the neurofibromin tumor suppressor gene, leading to increased tumor development. The finding suggests a new mechanism by which RNA editing can disable tumor-suppressing genes, potentially contributing to cancer progression.
A Phase II study demonstrates the efficacy of non-surgical radiologic intervention using heat in treating kidney cancers. Dr. Jonathan Lewin has successfully 'ablated' tumors in six patients with no recurrence, surpassing the normal three- to-six-month recurrence rate.
The environment plays a significant role in cancer development, with occupational factors and environmental pollution attributed to 5-7% of cancer deaths. Dr. Richard Clapp reviews the relationship between environmental exposure and cancer, emphasizing the importance of cancer prevention and physician screening for hazardous exposures.
Researchers at the University of Pennsylvania Cancer Center have successfully conducted a Phase I clinical trial on combretastatin A4 phosphate, a vascular targeting agent. The study found that patients with solid tumors were able to safely tolerate the treatment and showed evidence of decreased blood flow to the tumor.
The researchers created mouse models with benign and malignant NF1-related tumors to study the disease. The studies revealed that neurofibroma tumors invariably include cells lacking the NF1 gene, and that anti-Ras drugs might be useful in treating NF1.
Researchers at Yale University have successfully characterized the function of yeast genes, providing new insights into how human cells work. The study's findings could lead to better understanding and treatment of diseases like cancer.
Researchers at Thomas Jefferson University describe the workings of an enzyme caspase-9 crucial for understanding apoptosis. They hope to develop drugs that inhibit this enzyme to fight neurodegenerative diseases.
Scientists at NIH developed a new drug that reduces tumor size without severe side effects. In a clinical trial, 9 of 15 patients had significant tumor regression, with complete disappearance in two cases. A related therapy using virus-producing cells also showed promise, but only for small tumors.
Stephen Schneider proposes a 'meta-institution' to evaluate scientific assertions and urges citizens to ask experts for information. He recommends asking three questions: What can happen, what are the odds, and how do you know?, to help navigate complex decisions.