Research on cancer as a disease, from cause to care. Covers tumor biology, small-cell lung cancer, cancer-linked stroke risk, and cancer center research.
A study by Baylor College of Medicine researchers has identified cytarabine as the most effective and least toxic chemotherapy treatment for adult Langerhans cell histiocytosis patients. The study, published in PLOS ONE, reviewed health records for 58 adults with the disease and compared the effectiveness of three chemotherapy treatments.
Scientists have assembled a massive catalogue of protein data using a new method, providing unprecedented insight into protein phosphorylation. This understanding brings researchers closer to unraveling the mechanisms of disease.
Researchers have elucidated the structure of a key protein involved in DNA double-strand break repair. The MRN complex plays a crucial role in cell survival and function, with mutations linked to distinct syndromes and predispositions to cancer, radiation sensitivity, and neurodegeneration.
Researchers identified 20 distinct mutations in a specific gene causing Familial Glucocorticoid Deficiency (FGD), leading to cortisol production issues. The antioxidant gene NNT provides a new mechanism for this adrenal disease, potentially opening doors to treating other diseases.
Researchers have developed a new sensing device using nanomotors to detect chemicals at extremely low concentrations and high contamination. This technology has the potential to facilitate early disease diagnosis and treatment, such as cancer detection.
A recent analysis of 23,359 patients found that young CT scan recipients are more likely to die from their underlying disease than develop radiation-induced cancer. The study revealed a significantly lower risk of cancer induced by CT scans compared to the risk of dying from the disease.
Two distinguishable gene groups have been detected: one producing abundant biochemical products and functioning properly in most biological processes, and another with potentially abnormal function in diseases. The findings have significant implications for tailoring therapy to individual patients
Research suggests that individuals with polyglutamine (polyQ) diseases, including Huntington's disease, have a lower risk of developing cancer. This reduced cancer risk is thought to be due to the expansion of certain sequence repeats in specific genes, which impairs gene activity and leads to cell death.
A recent study published in the Journal of the American College of Radiology found that multi-detector CT scans pose a lower risk of developing secondary cancers among older adults. The researchers analyzed data from Medicare claims spanning eight years and estimated that only 0.03-0.04 percent of the population would develop radiation...
Scientists have identified a paradoxical function of the gene Chk1, which is typically known for its anti-cancer properties. In this study, researchers found that extra copies of Chk1 actually facilitate tumor growth in mice, highlighting the complex role of this gene.
Pasireotide significantly reduced urinary cortisol levels and improved symptoms of Cushing's disease, cutting secretion by 50% and returning some patients' levels to normal. The drug, which blocks ACTH secretion by binding to somatostatin receptors on the pituitary tumor, showed promise in treating this rare endocrine disorder.
Researchers discovered that inhibiting the activity of Forkhead boxO proteins prevents muscle loss in cancer and sepsis, while promoting muscle growth in healthy control animals. This breakthrough offers new potential treatments for muscle-wasting diseases.
The Society of Interventional Radiology will showcase new scientific advances and discoveries in its 37th Annual Scientific Meeting, featuring minimally invasive treatments for dozens of diseases. The meeting will include scientific presentations, posters, and technical exhibits highlighting research on interventional radiology.
Researchers at the University of Warwick discovered that cancer-causing genetic mutations exhibit distinct electronic properties, making them harder to detect. These mutations can be compared to stealth technology used in radar systems, which allows them to go undetected by the body's defense mechanisms.
Researchers at Brown University have created an unprecedentedly detailed description of a kinase complex, which could lead to new therapeutic drugs for diseases such as Alzheimer's and cancer. The team discovered a unique binding site, called KIS, that plays a crucial role in the complex's formation.
Researchers found genes associated with mitochondria and respiration are expressed at high levels in naked mole-rats, suggesting mechanisms for longevity and disease resistance. The study's findings provide clues on how the rodent protects itself against oxidative stress and may help understand aging processes.
Novel imaging agents detectable by PET imaging may visualize tumors in their earliest stages, enabling early detection and treatment of cancer. The compounds target COX-2, an enzyme found in inflammatory lesions and tumors.
A newly discovered metabolic pathway involving the dioxin receptor has been found to promote tumor growth and weaken the immune system in glioma patients. The research, published in Nature, suggests that inhibiting this pathway could be a potential target for cancer treatment.
A new study suggests that culling Tasmanian devils cannot control the spread of facial tumour disease and may even increase its transmission. Alternative strategies such as setting up insurance populations, finding genetic resistance, and developing a vaccine are being explored to save the iconic marsupial
Carissa Perez Olsen, a Fred Hutchinson Cancer Research Center scientist, has won the prestigious NIH Director's Early Independence Award. She will receive $1.25 million to study the mechanisms of cancer, aging-related diseases, and natural aging using C. elegans as a model organism.
The Lancet study finds that tobacco control measures immediately benefit health and reduce healthcare costs. The economic benefits of tobacco revenue are greatly offset by the savings from reduced smoking-related illnesses.
A Michigan State University researcher has developed a web-based genetics curricula with the goal of making the subject more engaging and accessible to students starting in fifth grade. The system, supported by a $2.3 million NSF grant, aims to improve students' understanding of genetic-related concepts.
A University of Nottingham researcher has been awarded a £600,000 Career Establishment Award to study the genetics of cancer. Dr Marios Georgiou aims to identify genes involved in tumour progression.
A team of scientists and medical doctors proposes an integrated method using systems medicine to investigate chronic non-communicable diseases as a group. This approach aims to provide personalized holistic treatment at the primary care level, reducing healthcare costs and burden.
Researchers discovered a simple blood test for the protein melanoma-inhibitory activity (MIA) can indicate neurofibroma presence. The level of MIA depends on neurofibroma size and growth.
Researchers found that orphan disease genes encode hub proteins with multiple protein-to-protein interactions vital to cell function. Deleting about 43% of these gene homologs is lethal or causes premature death, highlighting their essential survival role.
A University of Georgia study analyzed nearly 75,000 dog deaths over 20 years, identifying breed-specific risks and patterns. The research highlights the importance of anticipating potential health issues to manage wellness, particularly for rare breeds like the Bouvier des Flandres.
Scientists from Thomas Jefferson University have discovered that the protein FADD controls multiple cell death pathways, which could lead to better treatment options for autoimmune diseases and cancer. The study found that FADD regulates apoptosis and keeps necrosis at bay, allowing researchers to develop more targeted drugs with fewer...
A Scripps Research chemist devised a new method to quantify changes in proteins resulting from stress, which could provide insights into disease progression and treatment. The technique focuses on cysteine S-hydroxylation, allowing researchers to monitor protein modifications at the individual cysteine site.
Researchers identified key proteins controlling centrosome separation, which could prevent uncontrolled cell proliferation in cancer. Combining drugs against different regulators may reduce side effects and improve treatment outcomes.
A study by NC State University found that nearly two-thirds of cancer news articles contain uncertain terms, which can exacerbate public uncertainty. The researchers developed a scheme to identify and quantify uncertain terms in online texts.
A Phase III study showed that everolimus improves progression-free survival by 5.1 months in patients with advanced neuroendocrine tumors. The drug has antitumor efficacy in addition to currently available agents, offering new treatment options for rare cancers.
Researchers developed a new infrared light probe to study lysosomes, which could help diagnose and treat tumors. The breakthrough allows for longer periods of imaging without limitations.
Researchers found a genetic rarity where disease-causing genes can self-repair, resulting in spots of normal skin amidst diseased skin. The recombination of chromosomes prior to cell division leads to cells with either two mutant copies or no mutant copies, forming normal skin patches.
Researchers at UMass Medical School have discovered a new DAF-16 isoform that collaborates with other isoforms to regulate longevity and stress response in C. elegans. The newly found isoform, DAF-16d/f, works in concert with DAF-16a to promote organismal life span.
Radiofrequency ablation proved as effective as surgical removal of tumors in curbing cancer recurrence rates for up to five years after treatment. The minimally invasive procedure showed superior preservation of kidney tissue, leading to improved quality of life and length of life for patients.
The Canadian Partnership for Tomorrow Project is a major research platform studying disease causation in 300,000 Canadians over 30 years. It will investigate the complex interplay between environment, lifestyle, and genetics in cancer and chronic diseases.
Researchers found that calorie restriction influences the same molecular pathways related to aging in all animals studied, leading to improved health and reduced chronic diseases. By understanding these pathways, scientists may develop interventions or medicines to promote healthy aging.
The Life Sciences Discovery Fund has awarded nearly $15 million to three Washington state-based health research programs. The programs aim to enhance cancer diagnosis and treatment through innovative approaches, including computational tools and ultrasound technologies.
Researchers at Washington University in St. Louis have developed gold nanocages that selectively accumulate in tumors and convert laser light to heat, killing malignant cells. The treatment avoids warm surrounding tissue, making it a promising approach for cancer therapy.
Researchers at Yale University have streamlined the synthesis of a family of compounds known as kinamycins, which are naturally produced by bacteria and show potent toxicity. By reducing the number of steps required to synthesize them from 24 to 12, the team can now prepare these molecules in larger quantities for further studies.
Researchers may use epigenetics to assess potential harm from CT scans and other low-dose radiation. The study's author argues that future trends in diseases could be linked to current CT usage.
Yale researchers found that cancer-causing mutations can cooperate to promote tumor development even when located in different cells within a tissue. Stress conditions like wounds can trigger cancer formation by activating signaling process JNK.
Researchers identified tumor-suppressing genes ESR1 and HIC1 that predict late-stage laryngeal cancer and shorter survival in patients. Genetic abnormalities can aid in refining cancer staging and length of survival, potentially improving treatment options.
The article outlines seven key areas for improving spiritual care, including Spiritual Care Models and Training/Certification. The guidelines provide practical recommendations for implementing spiritual care in palliative care settings.
A new type of genetic change, a second copy of an entire gene, has been identified as a cause of familial chordoma, a devastating and rare form of cancer. The T (Brachyury) gene duplication was found in patients with the disease, but its exact mechanism is unknown.
Katsura Asano's research aims to understand protein building pathways in eukaryotic cells, which can play a role in cancer and chronic diseases. The study uses yeast as a model organism due to its similar protein-building process to human cells.
A palliative care intervention improved quality of life and mood in patients with advanced cancer, but did not reduce symptom intensity or hospital stays. The study suggests that comprehensive cancer care should address physical, psychological, and social needs.
A palliative care intervention improved quality of life and mood in patients with advanced cancer, but had no significant impact on symptom intensity or hospital stays. The study found that patients receiving palliative care reported higher quality of life scores than those receiving usual care.
A new study on Tasmanian devil social networks may help prevent the spread of an extinction-threatening disease. The research found that all individuals in a population are connected within a single social network, making it easy for disease to spread.
A study of 23,513 German adults found that four healthy lifestyle factors—never smoking, maintaining a healthy weight, exercising regularly, and following a healthy diet—were associated with an 80% reduction in the risk of developing chronic diseases. The largest reduction was seen in individuals with a BMI lower than 30.
Researchers at Weizmann Institute of Science have developed a program for biomolecular computers that enables logical thinking. The device can answer intricate queries involving multiple rules and facts, performing millions of calculations in parallel.
The study evaluated EUS features to distinguish GISTs from leiomyomas and found that inhomogenicity, hyperechogenic spots, a marginal halo, and higher echogenicity were more frequent in GISTs. The presence of at least two of these four features had high sensitivity (89.1%) and specificity (85.7%) for predicting GISTs. A maximal diamete...
Researchers have detected 3,600 acetylation switches in 1,750 proteins, significantly expanding the number of known modifications. This discovery sheds light on how protein regulation is affected by diseases like cancer, Parkinson's, and Alzheimer's.
Survival rates for placental-site trophoblastic tumours (PSTTs) vary depending on how long ago the related pregnancy occurred. The study found that patients with stage I disease had a 10-year probability of overall survival of 90%, while those with recurrent disease or disease resistant to treatment had poor survival.
Researchers at Helmholtz Zentrum München have identified the enzyme TFIIH kinase as responsible for selectively phosphorylating RNA polymerase II, regulating the production of specific RNA molecules. This discovery sheds light on epigenetic mechanisms and their significance in cancer and disease.
The NHLBI and UnitedHealth Group collaboration aims to broaden study beyond individual diseases to address chronic diseases as they group. Early results show encouraging progress in developing portable tools and comprehensive guidelines for chronic disease management.
Dr. Michael Holick's work revolutionized the understanding of vitamin D and its role in disease prevention, redefining vitamin D deficiency as a national epidemic.
Overall median survival improved from 3.5 months in period A to 12 months in period C, despite stage of disease at presentation affecting survival. Surgical resection is the only curative treatment, but many patients present with advanced-stage disease.
A Iowa State University researcher has figured out a mechanism involved in marking where DNA instructions are located in cells. The Gcn5 protein plays a crucial role in recognizing chemically modified histones, facilitating efficient gene reading and shedding light on diseases like cancer.