Research on cancer as a disease, from cause to care. Covers tumor biology, small-cell lung cancer, cancer-linked stroke risk, and cancer center research.
Researchers have discovered that host responses during sepsis progression can vary in important ways based on pathogen type. Boosting anti-inflammatory enzymes or using neuraminidase inhibitors showed therapeutic approaches, indicating a potential direction for drug development.
A large study in Shanghai, China found that socioeconomic development contributed to lower death rates for most diseases, likely due to lifestyle factors. Death rates from infectious diseases, maternal issues, and injuries decreased between 1974 and 2015.
A new white paper from the Pontifical Academy for Life recommends 43 strategies to improve global palliative care, aiming to alleviate the suffering of millions. The report was developed by an expert group representing different faiths and was published in Journal of Palliative Medicine.
Researchers at NUST MISIS and University of Calgary create method to monitor virus spread and immune system response in real-time using intravital microscopy. This breakthrough enables visualization of virus behavior in tissues and organs of living animals.
Researchers found that social isolation accelerates tumor growth in sick flies, while healthy flies avoid sick individuals with advanced tumors. This study suggests that social interactions play a substantial role in cancer development and progression.
Researchers discovered a molecular mechanism behind variable penetrance, where identical gene mutations have varying effects on disease severity. They found an enrichment of combinations of regulatory and coding variants that act as protective against disease by decreasing the penetrance of coding variants.
A blood test using a protein called KIM-1 can detect kidney cancer up to five years prior to clinical diagnosis. Elevated KIM-1 concentrations in the blood are associated with poorer survival rates in patients diagnosed with renal cell carcinoma.
Scientists discovered that mitochondria and nuclear genomes co-evolved to independently cross-regulate each other. This understanding could lead to greater insights into aging and disease, as well as new treatments based on mitochondrial DNA.
A team of researchers from CSIRO Australia has identified a new gene called C6 that regulates the body's immune response to infection and disease. The discovery could lead to targeted therapies for various diseases, including cancer, diabetes, and inflammatory disorders.
Researchers at Osaka University have successfully developed a new method for cancer diagnostics that uses single-molecule sequencing to investigate fluid dynamics of DNA molecules in solution. This method enables the detection of subtle differences in DNA sequences, allowing for more accurate diagnosis and treatment of cancer.
A study found that adults who survive nonfatal opioid overdoses are at high risk of dying from substance use-associated diseases, cancer, and circulatory system diseases. The study also revealed that women are more likely to die by suicide after surviving an overdose
Stopping expensive biological drugs for patients in remission or with low disease activity can save €7,133 per patient. This results in a small loss of 0.022 quality-adjusted life years and an increase in arthritis flares by 0.41 flares per year.
Researchers developed a computer algorithm called ALPACA to analyze gene networks in diseased cells, providing clues for cancer treatment. The approach could lead to novel strategies for preventing or curing disease, particularly for cancers that fail to respond to current treatments.
A calorie restriction trial in healthy adults aged 21-50 found significant improvements in biomarkers of aging, including reduced oxidative stress and slowed metabolic rate. The study suggests that sustained calorie restriction may help decrease risk for chronic disease and prolong life.
Research shows that Tasmanian devil populations are declining by 80 percent due to devil facial tumor disease, a rare and contagious cancer. Despite this, some wild populations are adapting with slight reproductive changes, such as younger breeding and more pouch young.
Researchers at Michigan Technological University developed a new cyanine dye that can work in water and exhibits fluorescence in acidic conditions. The dye has multiple benefits, including dual fluorescence under near-infrared and visible light, making it suitable for biomedical research.
Studies found tumors in tissues surrounding nerves in male rat hearts at high radiofrequency radiation levels, but not female rats or mice. Researchers also noted damage to heart tissue and increased cancer risk in exposed animals.
A study published in Age and Ageing predicts a massive expansion in the number of people suffering from multiple diseases, known as multi-morbidity, among older adults. As a result, two-thirds of life expectancy gains will be spent with four or more diseases.
Researchers at Tufts University have developed a new approach to analyzing complex genomic rearrangements (CGRs), enabling rapid and precise identification of their causes and impact on DNA and cellular formation. This breakthrough could lead to significant advances in diagnosing and treating genetic disorders and certain cancers.
Researchers developed activatable theranostic nanoplatforms that can highlight tumor cells during surgery using near-infrared fluorescence. These nanoparticles also demonstrated effective phototherapy to eliminate hard-to-remove tumors without harming healthy tissue.
Countries with underprepared health systems face a faster rise in noncommunicable diseases, requiring targeted investments to reduce modifiable risk factors and increase primary care access. The shift is driven by demographic factors rather than behavioral risks.
A study published in Journal of General Physiology investigated the functional effects of specific mutations in Na/K pumps found in tumors that induce primary aldosteronism. The researchers found that impaired sodium and potassium transport is a common mechanism behind the pathology, contradicting previous 'gain-of-function' proposals.
Researchers discovered how TORC1 protein complexes regulate cell growth in response to sugar availability. In the absence of sugar, these complexes self-assemble into massive tubular structures that halt cell growth. The formation and disassembly of these tubules can be easily observed in living cells.
Scientists at NGM Bio have uncovered the molecular biology and mechanisms of Growth and Differentiation Factor 15 (GDF15), a hormone regulating body weight. The study reveals potential therapeutics for diseases of excess and insufficient body weight, including obesity and cachexia.
Researchers have developed a method to accurately measure tiny changes in molecular interactions, which can predict cognitive impairment and diagnose mental illness. The technique uses optical tweezers to gauge the effects of gene mutations, offering a new approach to understanding complex diseases.
A comprehensive study reveals that childhood cancer survivors have a significantly higher cumulative burden of chronic disease, with an average of 17.1 conditions by age 50. The study suggests that these survivors may benefit from specialized healthcare delivery to manage their complex medical needs.
Researchers at TU Dresden and HTW Dresden found that cancer cells' adaptability affects tumour spread in complex environments, while simplicity worsens spreading. A theoretical approach to suppressing cancer cell plasticity has been proposed for further research.
Researchers develop noninvasive method to gauge cell stiffness, a key indicator of diseases like cancer and asthma. By analyzing particles' movements at high frame rates, scientists can determine a cell's mechanical properties without direct contact.
Practical imaging evaluation of neonatal soft-tissue tumors is crucial for accurate diagnosis, and clear understanding of imaging techniques can improve patient outcomes. Characteristic clinical and imaging findings aid in diagnosing these neoplasms, which may require biopsy or excision for definitive diagnosis.
Researchers at Marshall University found that patients who recover from invasive pneumococcal pneumonia have a significantly shortened lifespan compared to life expectancy tables. The study suggests that pneumococcal vaccination is crucial for all adults over 65 and younger adults with chronic diseases.
Scientists describe the first step of DNA packing in a cell, revealing how protein H1 helps compact and shield DNA. The discovery sheds light on genetic processes critical to understanding diseases like cancer and muscular dystrophy.
Researchers reconstructed green turtle skin in a lab to study tumor diseases and grow a virus called ChHV5. This breakthrough helps understand fibropapillomatosis, a deadly tumor disease affecting endangered turtles worldwide.
Researchers discover a new link between Zellweger syndrome and sugar metabolism, finding that the condition affects both lipid and carbohydrate pathways. This breakthrough could lead to new treatments for the rare disease.
A new program combining nutritional assistance, early mobilization, and daily communication protocols significantly reduced postoperative delirium rates by 56% in older patients. The intervention also led to a two-day shorter hospital stay for these patients.
Researchers found that devils with higher fitness rates are more likely to contract devil facial tumour disease (DFTD), a transmissible cancer. The study suggests that socially dominant individuals may be more susceptible due to their aggressive behavior and mating encounters.
A new UVA technique analyzes gene mutations at unprecedented scale and speed, enabling customized treatments for patients. This method may also help rescue failed experimental treatments by identifying the right mutation and gene activity.
A recent study by University of Missouri researchers has found that gallbladder cancer rates are decreasing in men, but not in women. The study also revealed a rising trend of late-stage diagnoses. Patients who received both surgical and radiation treatment experienced the highest survival rates.
A new noninvasive imaging test, sestamibi SPECT/CT, has been shown to accurately rule out kidney cancers. The test adds diagnostic information to conventional CT and MRI scans, improving physicians' ability to differentiate between benign and malignant tumors.
Researchers have discovered a protein called PorB, found on the exterior of bacteria, which can increase both antibody production and stimulate cytotoxic T cells to fight off infections. The study demonstrates the potential for this protein to enhance vaccine effectiveness against various diseases, including cancer and HIV.
Scientists have identified a cellular fuel sensor, AMPK, as a key regulator of the extracellular matrix and integrin function, which could lead to novel treatments for cancer and tissue fibrosis. The study reveals that AMPK's absence leads to increased adhesion and matrix production.
An international study has shown that immunotherapy can cure Tasmanian devils of the deadly devil facial tumour disease (DFTD). The treatment successfully triggered the devil's immune system to recognise and destroy established DFTD tumours, with tumours shrinking and disappearing over three months.
Scientists successfully delivered CRISPR-Cas9 to the eyes of mice with wet AMD, modifying the VEGF gene and reducing choroidal neovascularization (CNV) by 58%. This breakthrough could lead to a new therapeutic modality for non-hereditary degenerative diseases.
A team of scientists has created a device that screens breath samples to classify and diagnose several types of diseases, including kidney cancer and Parkinson's disease. The breathalyzer uses an array of nanoscale sensors to detect unique volatile chemical components in exhaled breath.
Researchers have discovered 75 groups of 'critical paralog' genes essential for cellular communication and signalling pathways. These findings will aid in guiding drug targets and identifying biomarkers for diseases such as cancer and neurodegenerative disorders.
A new technology platform has been developed to target cancer by inhibiting a well-validated cancer driver through amyloid formation. This approach could lead to the development of novel medicines for a wide array of diseases.
Scientists discovered a rare gene mutation that impairs lymphocyte development and function, providing new insights into the human immune system. A personalized therapy was also identified, using an approved drug to reverse some effects of the deficiency.
Researchers found two genomic regions changing in response to devil facial tumor disease, which has killed an estimated 80% of Tasmanian devils. The study suggests genetic resistance could help the species avoid extinction, with potential implications for cancer and immune function research.
The Association for Molecular Pathology has developed a new framework for defining the clinical utility of molecular diagnostics, emphasizing the importance of context in interpreting test results. This approach aims to improve patient care by providing clinically useful and appropriate testing based on realistic evidence levels.
Researchers found that crown gall tumors host a unique bacterial community with varying compositions compared to healthy vines. Some bacteria inhibit tumor growth while others provide protection and nutrients, helping control the disease.
Researchers at Barrow Neurological Institute have developed a new imaging tool that enables neurosurgeons to visualize brain tumor cells in real-time during surgery. This technology, known as confocal laser endomicroscopy, allows surgeons to identify and characterize tumor tissue more accurately than traditional methods.
A large study of 2,437 patients with stage II testicular seminoma found that radiation therapy was associated with better outcomes compared to chemotherapy, particularly in stage IIa disease. The study's findings support the recommendation for radiotherapy as the preferred treatment option for early-stage II testicular cancer.
Researchers developed a method demonstrating that independent DNA variants linked to a disease share similar biological properties. This discovery provides a more comprehensive picture of disease biology and offers the opportunity to broaden our understanding of disease and identify new therapeutic targets.
Researchers identified 3,870 SNP pairs with shared biological mechanisms across Alzheimer's disease, bladder cancer, and rheumatoid arthritis. These variants affect gene expression and protein function, providing a comprehensive picture of disease biology.
Researchers have developed an oxygen-independent photo-switchable molecule that attacks tumor tissue without oxygen, reducing side effects of conventional photodynamic therapy. The molecule, GS-DProSw, has been tested successfully on animal models and shows promise as a potential anti-tumor agent.
Researchers at UT Knoxville have discovered a novel regulatory pattern for cytokinesis, the final stage of cell division, triggered by the signaling protein Cdc42. This finding has implications for understanding cancer and other diseases, where defects in Cdc42 control are associated.
Cell biologists from Lomonosov Moscow State University discovered a new way to regulate cell motility, enabling the development of new medicines for cancer and vessel diseases. The study found that protein kinase LOSK regulates dynactin, a complex protein necessary for retrograde intercellular transport.
Scientists have developed a new imaging technique that can detect diseases earlier with enhanced sensitivity, allowing for earlier diagnosis and treatment. The technique uses probes that light up specific targets inside cells, enabling researchers to track changes in molecular make-up of tissues.
The University of Missouri has received a $1.3 million NIH grant to improve protein structure prediction using deep learning techniques. The research aims to increase the accuracy of predicting protein structures, which is crucial for breakthroughs in drug discovery, precision medicine, and disease detection.
Pagliarini's lab focuses on understanding mitochondrial function and its link to human diseases such as cancer, diabetes, and Parkinson's. His team is working to define the function of hundreds of 'orphan' proteins used by mitochondria.
Lund University scientists discovered that malignant tumors consume more sugar than surrounding tissue, making sugar a promising non-synthetic contrast agent. The study's results suggest the potential to reduce medical care costs by replacing metal-based agents with sugar-based alternatives.