Research on cancer as a disease, from cause to care. Covers tumor biology, small-cell lung cancer, cancer-linked stroke risk, and cancer center research.
Scientists developed a new technology to isolate 100% pure tumor and stromal cell populations from minute formalin fixed paraffin embedded specimens. This allows for downstream analysis of tumor genetic characteristics via next generation sequencing with unprecedented precision.
A study published in Gut journal reveals a 10-fold difference in bowel cancer cases and deaths worldwide, with higher incidence linked to economic development. The adoption of a Western lifestyle is suspected to contribute to the rising rates, particularly in low- and middle-income countries.
Scientists at the Institute of Molecular Biology have identified two proteins, Neil1 and Neil2, essential for DNA demethylation. These proteins boost the activity of Tdg, a central protein in DNA demethylation, promoting efficient removal of epigenetic marks.
The Association for Cancer Physicians has released a new strategy to improve cancer patient services and outcomes in the UK. The comprehensive plan focuses on delivering excellent and safe medical oncology care, contributing to NHS development, and providing innovative approaches to cancer care.
Researchers used a rare genetic childhood disease to reveal how cancer cells hijack a metabolic cycle to benefit themselves. The study found that silencing the ASS1 gene, which is lacking in some patients, can be beneficial for cancer growth and could lead to new treatments.
A new study reveals that ethnic minority populations face significant barriers to receiving quality end-of-life care, with financial resources and insurance being the biggest obstacle. The researchers emphasize the need for education, training, and support to improve end-of-life care among diverse patient populations.
A 24-year study found that chronic diseases disproportionately affect Bangladesh's poor, with mortality rates increasing dramatically among the lowest-income households. The shift underscores how chronic diseases have become 'diseases of poverty', dragging more people into poverty.
Individualized medicine is revolutionizing patient care through precision diagnostics, such as preventing drug-related adverse effects and identifying disease susceptibility. Whole exome sequencing is also offering new diagnoses for patients with undiagnosed diseases.
Researchers have found a way to mobilize immune cells to attack and destroy malignant tumors by using a cell surface receptor called GITR. This protein can switch immature T-cells from becoming regulatory T-cells to tumor killers called Th9 cells, which produce the cancer-fighting protein interleukin 9.
Researchers develop cell-free protein synthesis platform to manufacture human phosphoproteins, enabling study of protein function and structure. The technology has the potential to pave the way for new drugs for diseases such as cancer and Alzheimer's.
A study in nearly 800,000 patients found a positive association between carbonated beverage consumption and out-of-hospital cardiac arrests of cardiac origin. Limiting carbonated drink consumption may help reduce the risk of fatal cardiovascular disease.
Research finds that fishermen in Turks and Caicos Islands are increasing the local prevalence of a disease affecting turtle populations worldwide by selectively harvesting healthy creatures and throwing back infected animals. The study, published in Frontiers in Marine Science, suggests that this practice has the opposite effect of cul...
A new statistical method, Bayesian feature allocation models, can analyze next-generation sequencing data to determine the genetic composition of a patient's cancerous tumor. This information can help physicians select targeted drugs tailored to individual tumors.
Scientists have successfully tested a new tumor diagnosis method that uses molecular spies to detect diseased cells and visualize tumors. The method, which combines antibody-based detection with pre-targeting technology, has the potential to improve cancer treatment by using internal radiation.
Erlangen-based doctors have created a new classification system for brain tumors that predicts the development of gliomas with high precision. The Friedlein Grading A/B (FGA/B) system classifies tumors according to their position in the brain on routine MRI scans.
A study by Northwestern University scientists found that a Vibrio vulnificus toxin can inhibit tumor cell growth by cutting the Ras protein, which is central to cell division and survival. The toxin's ability to cleave Ras, rather than modify it, represents a novel mechanism for inactivating this protein.
Research suggests people with MS may have double the risk of dying early compared to those without the disease. Younger individuals with MS are particularly vulnerable, facing a three times higher risk of death.
Higher adherence to the Dietary Guidelines for Americans was associated with a 14-23% lower mortality rate from cardiovascular disease, cancer, and other diseases in a low-income population in the southeastern US. Participants with the healthiest diet had only about 80% of the risk of death compared to those with the least healthy diet.
Research finds 9/11 emergency medical services workers, especially those on the scene, are at high risk for physical and mental ailments. The study tracked 2281 NYC Fire Department workers over 12 years, finding nearly all health conditions analyzed were more prevalent among those who arrived earliest.
At SIR 2015, Robert K. Kerlan discussed the need for collaboration between interventional radiologists and the broader medical community to address changing healthcare economics and practices. Kerlan emphasized the field's potential for improving patient care through innovative therapies.
The global spread of asbestos is a pressing concern, with over 50 countries banning the substance due to its deadly health risks. India and the US remain among the largest producers and importers of asbestos, contributing to the ongoing challenge to global health.
Scientists at Max Planck Institute find millions of gene forms, 85% genes without predominant form, and 4,000 disease genes. The dual nature of human genomes reveals individual diversity in interactions between genes.
The authors argue that public health interventions should focus on breaking social habits rather than individual behavior changes. By re-shaping socially acceptable norms, policymakers can tackle non-communicable diseases such as heart disease, cancer, and diabetes.
A team at Florida State University has made a new discovery about how human genetic material replicates within a cell's nucleus. The findings could lead to novel treatment options for cancer patients and those who benefit from stem cell-based therapies.
Researchers have discovered ferroptosis, a regulated form of necrosis that occurs in various pathological conditions. Ferroptosis inhibitors, such as Liproxstatin-1, offer novel therapeutic opportunities to mitigate diseases previously thought to be untreatable.
Researchers developed a fluorescence imaging technique to accurately identify protein receptors in tumors without tissue biopsy. The new approach strongly correlates with clinical immunohistochemistry and may impact oncology patient outcomes.
Researchers at UT Southwestern Medical Center have identified the specific type of cell that gives rise to large, disfiguring plexiform neurofibromas, a finding that could lead to new therapies for preventing tumor growth. The study suggests ways to develop treatments by understanding the steps leading to tumor development.
Researchers discovered that dendritic cells trigger lymph node expansion by producing CLEC-2, allowing immune cells to gather and launch an attack against infections and cancer. The study provides new insights into the immune system's role in diseases, including cancer.
Researchers create genetic profile of grape crown gall tumor disease, identifying core microbiome common to 52 sampled tumors. The study aims to improve disease management and crop production of all grape varieties.
A new study by researchers from NIST and the Hollings Marine Laboratory found that persistent organic pollutants (POPs) are not linked to fibropapillomatosis, a disease causing tumors in green sea turtles. The team detected halogenated phenols in turtle tissues, suggesting these compounds may be coming from algae in their diet.
Researchers are drawing attention to the rare disease due to its misdiagnosis. Caused by small benign tumors in the pituitary gland, it can lead to excessive weight gain, acne, and a lump on the back of the neck.
A University of Houston chemist has received a $600,000 NSF CAREER Award to develop synthetic strategies for increasing the efficiency and yields of chemical reactions. The goal is to improve the treatment of diseases such as cancer and malaria by better understanding molecular reactivity.
Researchers have identified two distinct pathways that influence the aggressiveness of pediatric brain tumors, suggesting different treatment approaches. The study found that point mutations in the BRAF gene lead to a more aggressive form of the disease than K:B fusion.
Researchers have identified a key chemical that can repair damaged cell nuclei, a breakthrough in treating Hutchinson-Gilford Progeria Syndrome (HGPS), a rare and devastating ageing disease. The compound, Remodelin, also shows promise in reducing DNA damage and improving cellular health.
A new analysis finds that research on diseases of the poor is disproportionately underfunded, exacerbating global health disparities. The study suggests that boosting scientific research within poorer countries could help close this gap and increase studies on underserved diseases.
A study of over 65,000 adults found that consuming at least seven daily portions of fruit and vegetables was associated with a lower risk of death. The analysis revealed that eating more than five daily portions may be needed to reap the full benefits, and that processed fruits may even increase the risk of death.
Research on Tasmanian Devil Facial Tumour Disease reveals that human selection can accelerate the evolution of cancerous cells. The study found that tumours from devils subjected to disease suppression trials showed accelerated temporal evolution of tetraploidy, allowing them to adapt to changing environments.
A new method for purifying peptide-based drugs has been developed by a chemist at Michigan Technological University, separating perfect peptides from those that don't make the grade in just two hours. The process reduces waste and is cheaper than existing methods, offering a promising alternative for treating diseases like cancer and HIV.
Researchers discovered a 500-million-year-old chemical bond essential for animal life, which could lead to new cancer therapies. The sulfilimine bond is formed by hypohalous acids and is crucial for blood vessel formation.
The REiNS Collaboration has established a framework for standardized outcome measures in neurofibromatosis clinical trials. The new guidelines address patient-reported outcomes, functional outcomes affecting vision, hearing and facial function, imaging tumor response, and disease biomarkers.
Researchers create progerin-induced aging in stem cells, accelerating disease modeling by weeks, not years. This breakthrough opens avenues for preventing and treating late-onset disorders.
Researchers have developed a device that can sort human cells based on their stiffness, which may help doctors diagnose diseases more accurately. The technology uses microfluidic channels and ridges to separate cells into two streams depending on their mechanical properties.
Researchers have developed a new method to pinpoint single DNA mutations, which could aid in diagnosing and treating diseases like cancer and tuberculosis. The technology is robust, easy to use, and suitable for low-resource settings.
Autophagy, a process where cells consume parts of themselves to clean up damaged organelles and proteins, is controlled by a molecular switch in the cell nucleus. The study found that histone H4 acetylation regulates autophagy-related genes, offering new avenues for disease treatment.
A large study found that people with Alzheimer's disease had a cut in half risk of developing cancer, and those with cancer had a reduced risk of developing Alzheimer's by 35%. The researchers controlled for life expectancy to confirm the findings.
Scientists have developed a roadmap for ATP-binding cassette (ABC) transporter proteins, crucial components of every cell that are involved in tumor resistance and disease. Understanding how these proteins interact with other vital components can help develop targeted drugs to treat diseases such as cystic fibrosis, cancer, and others.
Scientists have identified the molecular mechanisms underlying the onset of common leiomyomata, a type of benign tumour that affects millions of women. The study suggests that complex chromosomal rearrangements may underlie the development of these tumours, and highlights potential avenues for novel pharmacological treatments.
Researchers found that nearly three-quarters of high-grade bladder cancer patients experience disease return within 10 years. Intensive surveillance and treatment can reduce recurrence rates, with a single instillation of chemotherapy showing promise in minimizing recurrences.
Researchers at UCLA have identified TR4 as a key driver of tumor growth in Cushing disease. By knocking down TR4 in lab mice, they reversed tumor growth and excess ACTH production, paving the way for potential drug therapy.
Thijn Brummelkamp receives the EMBO Gold Medal for his groundbreaking work on genetic analysis of human disease. His RNA interference method has been cited over 3500 times and enables detailed study of human genes involved in diseases like cancer.
Researchers at the Salk Institute have identified TR4 as a protein that drives the formation of pituitary tumors in Cushing's disease, which could lead to a new therapeutic approach for this potentially life-threatening disorder. The study found that targeting this pathway could benefit treatment of CD.
Researchers identified five trajectories for patients with end-stage heart failure, providing a framework to predict the path to death and improve quality of life. The study's findings can help caregivers plan for the last months of life, enabling patients to gain control over their illness.
Researchers have discovered that protein machines that copy DNA pause frequently during the process, creating potential for dangerous mutations. Efficient repair of these breakdowns is crucial to prevent corruption of the genetic code.
Researchers have generated mutations in almost 40% of zebrafish genes, creating a resource for understanding physical and biochemical consequences of genetic variation. The study aims to reveal the function of each gene in zebrafish to shed light on human disease.
The new system uses micro-robotics to provide surgeons with a better view of bladder tumors, allowing for more accurate diagnoses and easier tumor removal. The device can operate in challenging environments and has been shown to have sub-millimeter precision.
Researchers argue that traditional notions of healthy and successful aging fall short for many Canadians living with chronic diseases. Instead, they advocate for supporting older adults to live well according to their own definitions of health.
Mice with Alzheimer's-like pathologies showed improved memory and slower disease progression on a low-protein diet supplemented with specific amino acids. The study found reduced levels of IGF-1 and increased blockade of its effects, suggesting potential non-invasive treatments.
A recent analysis of data published in Archives of Disease in Childhood found that boys whose testes fail to descend at birth are almost three times as likely to develop testicular cancer. The condition affects around 6% of male births and has been linked to a higher risk of developing the disease.
Research found that Tasmanian devils with fewer bites are more likely to develop Devil Facial Tumour Disease (DFTD), a fatal infectious cancer. The study suggests that boosting natural selection of less aggressive devils could help reduce the spread of the disease and save the species from extinction.
Researchers have discovered that archived Guthrie cards hold valuable epigenetic information about newborns, which can be used to predict future health outcomes. The study found that these marks are present at birth and remain stable into early childhood, offering a unique window into the development of diseases.