A team of neurosurgeons has discovered the origins of the homunculus, a famous brain concept devised by Wilder Penfield. The study reveals that the iconic map was created from Edwin Boldrey's 1936 thesis, which analyzed electrical brain stimulations in human surgery.
Researchers at Barrow Neurological Center discovered aberrant RNA processing in ALS and FTD patients, led by Dr. Rita Sattler's team finding ADAR2 mislocalization affects disease pathways, potentially leading to neuronal loss and neurodegeneration.
Researchers at Barrow Neurological Institute have developed a new clinical trial regimen for treating glioblastoma, a complex brain tumor. The study demonstrates the ability of the drug AZD1775 to penetrate brain tissue and provide clinically-relevant activity against human glioblastoma.
The Ben and Catherine Ivy Foundation has partnered with Barrow Neurological Institute to fund a $50 million effort to accelerate drug discovery and clinical testing for glioblastoma. The new Ivy Brain Tumor Center aims to provide individualized experimental therapies to malignant brain tumor patients worldwide.
Researchers evaluated state-of-the-art optical technology in commercial-grade operating microscopes to detect fluorescence signals produced by pro-drug 5-ALA. They found variability in signal intensity and bleaching rates, highlighting the need for standardized methods and built-in standards for reliable detection and measurement.
A new surgical imaging instrument using Scanning Fiber Endoscope (SFE) technology has been developed to detect the fluorescent glow of malignant brain tumors. This allows neurosurgeons to visualize the tumor more accurately, enabling them to remove more tissue and potentially improve patient outcomes.
Researchers at St Joseph's Hospital and Medical Center discovered a mechanism that causes TRPV1 blockers to affect body temperature. The team found that blocking this activation can prevent hyperthermia and hypothermia in new compounds.
Researchers have validated five new genes responsible for Amyotrophic Lateral Sclerosis (ALS), a fatal neurological disorder. The study uses AI-powered technology to accelerate the discovery of new treatments by identifying key proteins linked to the disease.
Researchers developed a novel imaging technique to assess patients with lumbar spine degeneration, providing precise assessments of water content changes in the intervertebral disk. This technology aims to recognize and predict disease earlier, enabling better treatment choices.
Researchers at Norton Thoracic Institute have developed a new approach to treat an aggressive subgroup of lung cancer. The study found that patients with tumors harboring specific genomic mutations, such as KRAS and LKB1, are more likely to benefit from a novel drug in clinical trials.
Subarachnoid hemorrhages account for 5-10% of all strokes, particularly among younger patients, and can result in long-term neuropsychological effects. Expert treatment is crucial, with high-volume centers and specialized neurosurgeons offering the best outcomes.
A new study published in Science Translational Medicine reveals that monitoring Zinc finger and BTB domain-containing protein 7A (ZBTB7A) can be an early predictor of chronic lung allograft dysfunction (CLAD). This discovery fills the void for a reliable marker, opening new opportunities for diagnosis and prevention.
Researchers at Barrow Neurological Institute have identified a link between domestic violence and traumatic brain injury, with 88% of victims suffering more than one head injury. The study aims to expand awareness and treatment options for domestic violence survivors, who often lack access to resources.
Researchers at Barrow Neurological Institute found the roots of modern humane medical practices in a pioneering French physician, Andre Feil's 1919 medical school thesis. The thesis challenged long-held opinions about people with deformities and emphasized treating patients with dignity and honor.
Researchers at Barrow Neurological Institute have developed a new imaging tool that enables neurosurgeons to visualize brain tumor cells in real-time during surgery. This technology, known as confocal laser endomicroscopy, allows surgeons to identify and characterize tumor tissue more accurately than traditional methods.
A Phase 2 study demonstrated the safety of deep brain stimulation (DBS) in treating mild Alzheimer's disease. No adverse effects were reported, but the next step is evaluating efficacy and longer-term safety in a larger patient population.
Researchers at St. Joseph's Hospital and Medical Center found that a standard front-line treatment for advanced ovarian cancer should involve every three week chemotherapy with carboplatin, paclitaxel plus bevacizumab, or weekly dose intense paclitaxel without bevacizumab
Researchers at Barrow Neurological Institute found that Massot's modern neurosurgical techniques played a critical role in Kutuzov's survival and ultimate victory over Napoleon. The brain surgery allowed Kutuzov to make the best decision, avoiding a confrontation with Napoleon's superior forces.
Researchers at St. Joseph's Hospital and Medical Center discovered a new treatment for ovarian cancer that improves response rates and prolongs time until cancer recurrence. Trebananib, a peptide-Fc fusion protein, targets angiogenesis by inhibiting angiopoietin 1 and 2 binding to the Tie2 receptor.
A randomized, double-blind trial of 621 adults found that Bevacizuman did not prolong survival for newly diagnosed glioblastoma patients. The results contradict earlier studies showing the drug's effectiveness in other diseases.
A multi-site research project led by Dr. Bradley J. Monk found that women with advanced cervical cancer live an average of 17 months longer when combined with bevacizumab and chemotherapy compared to chemotherapy alone. The study reveals a significant improvement in treatment outcomes for patients with metastatic cervical cancer.
Brain researchers at Barrow Neurological Institute have discovered that healthy observers and neurological patients scan visual scenes with the same general strategy, regardless of scene size or fixation status. This finding challenges previous concepts of exploration and fixation as fundamentally different behaviors.
A recent study published in The Lancet Oncology reveals that patients with low-grade serous carcinoma of the ovary or peritoneum can experience tumor stabilization or shrinkage after taking a regular dose of selumetinib. This breakthrough discovery offers new possibilities for treating previously chemoresistant tumors.
Researchers at Barrow Neurological Institute found that a ketogenic diet significantly enhances the anti-tumor effect of radiation, leading to improved survival rates for mice with malignant gliomas. The study suggests that the diet could be used as an adjuvant therapy without FDA approval.
Lung cancer researchers at St. Joseph's Hospital and Medical Center identified a gene involved in non-small cell lung cancer tumor growth, leading to potential new treatments that inhibit tumor growth. The study found that the Fn14 gene is elevated in NSCLC tumors and promotes migration and invasion.
Researchers discovered a 'temporal sweet spot' that optimizes perceived brightness of light without increasing power. This finding could lead to significant energy savings by redesigning light-emitting devices to flicker with optimal dynamics.
Researchers at Barrow Neurological Institute and Arizona State University have made a breakthrough in understanding why brain tumors are difficult to treat. The study reveals that the immune system behaves differently in different regions of the brain, including tumors, leading to potential limitations in effective treatment.
Researchers at Barrow Neurological Institute found that curved motion triggers smooth pursuit eye movements, while straight motion leads to saccadic eye movements. This discovery could have wide-reaching implications in various fields.
Physicians at Barrow Neurological Institute have written a biography of Ukrainian anatomist Vladimir Betz, who discovered giant pyramidal neurons known as Betz cells. These cells' function with cortical organization was a turning point in neuroscience, revolutionizing cell fixation and staining methods.
Researchers identified a new pathway of stem cell activity in the subventricular zone of the human brain, which targets the prefrontal cortex in newborns. This discovery challenges previous reports that suggested neural stem cells remain active into adulthood.
Dr. Robert Garfield, a researcher at St. Joseph's Hospital and Medical Center, has received a $100,000 phase 1 grant from the Bill and Melinda Gates Foundation to develop a device that can prevent post-partum hemorrhage, a major cause of mortality in pregnant women worldwide.
Thurston worked with Dr. Nader Sanai to create a detailed Gantt chart, compressing the project timeline from five to three years and reducing expenses. The gift agreement includes financial incentives, motivating Dr. Sanai to achieve specific goals on a quarterly basis.
A study led by Dr. Andrej Romanovsky found that mice with TRPV1-deficient receptors exhibited higher locomotor activity, especially during the day, suggesting a suppressive effect of TRPV1 on physical movement.
Research led by Dr. Fu-Dong Shi at Barrow Neurological Institute revealed that natural killer cells play a critical role in controlling CNS inflammation and immune response. Enriching affected areas with NK cells improved disease symptoms, while blocking them worsened outcomes.
A renowned gynecologic oncologist expresses concerns about a major ovarian cancer study, highlighting the need for targeted genetics-based treatments over delayed treatment timing. The study found no significant difference in survival rates between early and delayed chemotherapy groups.
Barrow scientist A.D. Bud Craig is leading the global conversation about the insula, a hidden lobe of the brain involved in virtually every human emotion and behavior. The latest research indicates that the insula plays a crucial role in conditions such as addiction, anxiety, depression, and schizophrenia.
A Barrow scientist has been awarded a major grant from the Muscular Dystrophy Association to continue his research on myasthenia gravis, an autoimmune disease that causes muscle weakness and fatigue. The $450,000 grant will focus on Th17 cells, which may play a key role in causing or intensifying autoimmunity.
Researchers at the Muhammad Ali Parkinson Center are conducting a study to determine if simple exercise can help protect neurons in the brain from Parkinson's disease. Participants will follow a structured exercise program called pole-striding, which involves walking with ski-like poles, for 12 weeks.
A new miniature microscope enables neurosurgeons to visualize brain tumors in real-time, allowing for more precise removal and accurate diagnosis. This technology has the potential to reduce surgery time by up to 40 minutes and improve patient outcomes.
A Barrow scientist has received a $400,000 grant to investigate Von Economo Neurons (VENs), cells potentially linked to quick decision making and social disabilities in autism. The research aims to understand the neural basis for human awareness and VENs' role in species evolution.
A Barrow researcher has received a $275,000 grant from the NIH to develop an artificial system to produce a6 nicotinic receptors, which may be a new target for smoking cessation therapies. The project aims to study drug interactions with this key receptor and develop more effective treatments with fewer side effects.
Dr. Susana Martinez-Conde and her team will record neural activity in the brain's visual areas to understand why images appear stable during fixation. They aim to determine at what level of the brain visual perception becomes stable, shedding light on this critical aspect of our visual experience.
Dr. Andrej Romanovsky has been awarded a $1.8 million grant to study the mechanisms of fever and hypothermia in systemic inflammation. His research aims to gain insight into the therapeutic use of anti-inflammatory drugs.
A Barrow researcher has received a $120,000 grant to study flicker fusion and its impact on people with epilepsy. The goal is to develop safe brain products that can make artificial lighting appear stable to the brain.
Researchers at Barrow will investigate gene defects in NF1 affecting nerve cell function and molecule movement. The grant aims to identify new targets for treating Neurofibromatosis 1, a genetic disorder causing tumors and developmental problems.
Researchers at Barrow and Arizona State University will develop new hydrogels to stimulate spinal cord growth and treat brain tumors. The studies aim to improve treatment options for patients with malignant brain tumors and spinal cord injuries, building on the center's reputation as a top neuroscience hub.
Researchers at Barrow will study neurons from HH tumors to understand why seizures occur and how GABA causes excitation instead of inhibition in some HH neurons. The study aims to develop new strategies for treating gelastic epilepsy.
Dr. Liu has discovered a mechanism underlying immune system modulation of Multiple Sclerosis (MS) and will optimize therapy using NKT cells. The Muscular Dystrophy Association fellowship award supports her three-year research project.
A year-long study using functional Magnetic Resonance Imaging (fMRI) technology has localized a small area in the occipital lobes of the brain responsible for generating visual awareness. This breakthrough discovery clarifies how our brains process visual information and recognize stimuli as visible.
Researchers have established that microsaccades are responsible for driving 80 percent of our visual experience, resolving a scientific debate. This discovery brings new hope to patients who are blind much of the time due to fixational eye movement problems.