Articles tagged with Hemoglobin Disorders
New national standards recommend earlier screening and lifelong monitoring for development and cognition in individuals with SCD, aiming to reduce variability in care. The guidance, developed in collaboration with Children's Colorado, provides a tiered approach to care, including surveillance and evaluation.
A new study reveals significant variation in sickle cell disease hospitalizations and costs across New York State, with regional differences in access to specialized care and treatment impacting outcomes. Long Island and New York City show high costs and complex cases, while Central New York has the longest average length of stay.
New research has found that immature red blood cells can import heme from surrounding cells, overcoming long-standing assumptions about heme and red blood cells. This discovery could lead to new therapeutic approaches for inherited genetic blood disorders such as β-thalassemia.
A gene-edited treatment has shown remarkable success against severe sickle cell disease, with 27 out of 28 patients achieving a functional cure and no painful crises. The therapy uses CRISPR/Cas12a technology to modify stem cells and increase levels of fetal hemoglobin.
A nationwide study found that periods can trigger severe pain in many women and girls with sickle cell disease, leading to emergency department visits and hospitalizations. The study's authors recommend a routine menstrual history screening as part of annual sickle cell care and connecting patients with reproductive health specialists.
A new survey found that 72% of respondents agree that plasma-derived medicines can save lives, but most haven't donated. Plasma is essential in producing treatments for various serious health conditions.
A recent study found that strict adherence to High-Throughput Sequencing (HTS) technology based carrier screening can achieve high efficiency in preventing severe thalassemia birth defects. The study identified 15.07% of women as carriers of thalassemia and confirmed 59 fetuses with severe thalassemia, all of which were in high-risk co...
HemaChrome's machine learning-based technology enables instant and noninvasive measurement of blood hemoglobin levels from digital photos, facilitating point-of-care diagnostic tests. The collaboration with Global Health Labs aims to address anemia diagnosis gaps in low- and middle-income countries.
CHOP and Penn Medicine researchers have developed a proof-of-concept model for delivering gene editing tools directly into diseased blood cells within the body. This approach aims to reduce costs and increase access to gene therapies for blood disorders, which currently require chemotherapy and stem cell transplants.
Researchers found that adapted D-dimer thresholds are safe and efficient for ruling out acute pulmonary embolism, even in high-risk patient subgroups. Strategies with adapted thresholds have up to 3-fold increased efficiency, but also higher predicted failure rates.
A new study from UCLA has found that women experiencing extreme morning sickness during pregnancy are three times more likely to have children with attention disorders and language delays. In utero exposure to HG may be linked to nutrient deficiency and life-long effects on the exposed fetus.