Articles tagged with Lung Cancer
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Researchers found that silencing of a crucial gene in lung cancer leads to impairment in genome-wide changes, contributing to cancer development and progression. Tobacco use is strongly linked to modification of the MTHFR gene, which triggers global hypomethylation and deregulation of DNA synthesis.
A research team at UC San Diego has identified a protein called versican that enhances metastasis by stimulating inflammatory cells. Versican is found in low amounts in normal lung epithelial cells but is upregulated in aggressive lung tumors, supporting the growth and spread of cancer.
Research suggests that high intake of inorganic phosphates, found in processed foods, can stimulate lung cancer development and growth. Dietary regulation of phosphates may play a critical role in treatment and prevention of the disease.
Research identified common variants in ABCB1 and ABCC1 genes that increase lung cancer risk. Variants were found more often in patients than controls, particularly in women and younger individuals. These findings may help prevent tobacco-related cancers.
Researchers have identified a gene mutation in SFTPA2 that is linked to an inherited form of idiopathic pulmonary fibrosis, a lethal lung disease affecting older adults. The same mutation is also associated with lung cancer.
Researchers at University of Nottingham identified the tumour suppressor gene LIMD1 as a protector against lung cancer. The study found that LIMD1 was missing in majority of lung cancer samples, indicating its protective role. This breakthrough could lead to early screening techniques and treatments for lung cancer.
Researchers found that combining PI3K and MEK inhibitors led to significant tumor shrinkage in mice with lung cancer driven by K-Ras mutations. The combination treatment eradicated the tumors with minimal toxicity, providing a strong rationale for testing this therapy in human trials.
According to a recent report, cancer incidence and mortality have declined in the US for the first time among both men and women. The decline is attributed to decreases in the most common cancers, including prostate, lung, and colorectal cancer.
The report found declines in both cancer incidence and death rates, as well as wide variations in lung cancer trends from state to state. Tobacco control measures are key to reducing the risk of lung cancer.
The report reveals declines in cancer incidence and death rates across the US, with some states experiencing significant variations in lung cancer trends. These findings underscore the need to strengthen tobacco control programs and accelerate efforts to prevent or reduce the occurrence of kidney and liver cancers.
A team of researchers found that a tiny protein called alpha-catenin is essential for forming strong bonds between cells. Cancer cells with dysfunctional alpha-catenin can break free and spread the disease, but scientists may be able to develop therapies to repair or replace this protein and prevent cancer's progression.
The INTEREST study found oral gefitinib comparable to injected docetaxel in non-small cell lung cancer patients, with better quality of life. Common side effects included rash and diarrhoea with gefitinib, while neutropenia and asthenic disorders were more common with docetaxel.
A study published by the American Association for Cancer Research found that cruciferous vegetables like broccoli may lower lung cancer risk in smokers. The study showed a significant protective effect, with risks ranging from 20% to 55% depending on the type and duration of smoking.
Researchers studied DNA methylation in former smokers and found differences between those with lung cancer and disease-free individuals. Altered methylation levels may explain why some former smokers develop lung cancer despite quitting smoking.
A study found that African-American patients with non-small cell lung cancer have a higher copy number of the epidermal growth factor receptor (EGFR) gene, predicting better long-term outcomes when taking erlotinib and gefitinib. Few EGFR mutations were observed, highlighting the need for more research in this patient population.
A recent study published by the American Society for Radiation Oncology found that males diagnosed with non-small cell lung cancer have a higher mortality rate than females. The research also revealed that gender is a significant prognostic factor in lung cancer patients' overall survival rates.
A phase III clinical trial found that adding bevacizumab to erlotinib therapy improves progression-free survival in advanced non-small cell lung cancer patients, but not overall survival. The combination also shows a response rate and tumor shrinkage.
A multi-center phase II clinical trial found improved survival in patients with advanced non-small cell lung cancer treated with chemotherapy and targeted therapies bevacizumab and cetuximab. The combination showed no safety concerns, indicating a potential future treatment option for lung cancer.
Researchers found that proton therapy with concurrent chemotherapy significantly reduced bone marrow toxicity in patients with locally advanced non-small cell lung cancer, improving treatment efficacy and patient outcomes. The study suggests proton therapy as a safer option for vulnerable patients, including children and the elderly.
A study led by The University of Texas M. D. Anderson Cancer Center has found a four-drug regimen of carboplatin, paclitaxel, bevacizumab, and cetuximab to be safe for patients with advanced lung cancer. The regimen showed modest improvement in survival rate, with 53% of patients experiencing tumor shrinkage.
A new Cornell study found a strong relationship between allergies and cancer in tissues exposed to environmental factors, such as eczema, hives, and hay fever. Allergies linked to these conditions were most strongly associated with lower rates of cancers in exposed tissues.
Researchers found that allergy symptoms may protect against cancer by removing foreign particles and substances from organs that come into contact with them. However, the relationship between asthma and lung cancer is a special case where asthma actually increases lung cancer rates.
Researchers found that in-home photography may be a cost-effective alternative to professional visual home assessments for identifying asthma triggers. Additionally, health-care utilization for children with asthma peaks in the fall, while tadalafil shows promise as an effective therapy for pulmonary hypertension. In-hospital statin us...
New report finds lung cancer media coverage is on the rise, but with a significant decrease in positive coverage and an overemphasis on smoking as a risk factor. Despite this, breast cancer coverage remains more favorable, often featuring personal stories of survivors.
A study by Stanford Cancer Center found that younger patients (15-39 years) with lung cancer exhibit better survival rates and distinct clinical features compared to older patients. The age-adjusted incidence rate of lung cancer in younger patients was significantly lower, and they had a higher proportion of distant disease at diagnosis.
Researchers found that video-assisted thoracic surgery (VATS) for stage I non-small cell lung cancer results in shorter post-operative hospital stays and faster removal of chest tubes compared to traditional open surgery. The study also showed comparable outcomes in terms of surgical success and complication rates.
Research found skewed X inactivation in women with BRCA1 gene mutations, associated with a later onset of breast or ovarian cancer. The Impact of Cancer scale was also refined and validated, providing a tool to measure long-term psychosocial impact on cancer survivors.
Researchers have discovered 26 new genes linked to lung adenocarcinoma, a type of non-small cell lung cancer. The study's findings suggest that these genetic alterations can be targeted with specific treatments, offering new hope for patients.
A study of 188 patients revealed 26 genes involved in the development of lung adenocarcinoma and its sub-types, including those in non-smokers. The findings could lead to improved diagnosis and treatment options for this deadliest form of lung cancer.
A collaborative study of nearly 200 lung cancer patients has identified over 1,000 genetic alterations and pinpointed 26 frequently altered genes. The research highlights the importance of integrating multiple large-scale approaches to highlight key molecular defects in lung tumors.
A Harvard T.H. Chan School of Public Health study projects that China will experience an estimated 65 million COPD deaths and 18 million lung cancer deaths between 2003 and 2033 if current smoking and biomass fuel use levels continue, highlighting the need for large-scale interventions to reduce disease burden
A study finds that eliminating smoking and solid fuel use in China could prevent millions of deaths from chronic diseases. Gradual elimination or moderate-aggressive interventions could avoid 26-31 million COPD deaths and 6.3 million lung cancer deaths by 2033.
Scientists identified P-Cadherin as a key molecule in causing colon cancer, with abnormal expression leading to pre-cancerous growths in the bowel. Their findings hold promise for preventative therapies and lifestyle changes to prevent or treat the disease.
A study analyzing English cancer patients found that cervical and lung cancer rates are higher among poor people, while breast and melanoma rates are higher in wealthier groups. Smoking is strongly associated with socioeconomic status and contributes to the higher incidence of lung cancer in deprived groups.
A study of 20 recorded interactions found that physicians rarely responded empathetically to concerns raised by patients with lung cancer. Opportunities for empathy were most often related to the impact of lung cancer on patients' morbidity and mortality expectations, but were frequently overlooked by physicians.
A study published in the Archives of Internal Medicine found that physicians rarely responded empathically to patients' concerns about mortality, symptoms, or treatment options. The researchers identified 384 moments of
In a phase II trial, pazopanib was found to shrink lung cancer tumors in 30 out of 35 patients by up to 85%. The results suggest that pazopanib is highly active in early stage operable lung cancer. Further development of this drug in lung cancer is underway.
Multidisciplinary approaches combining chemotherapy, radiotherapy, and surgery have shown promise in treating various cancers, including lung and head and neck cancers. The addition of targeted therapies like pazopanib and cetuximab has demonstrated significant activity in reducing tumor size and improving patient outcomes.
A new blood test uses immune system signals to detect early signs of lung cancer, signaling the disease before symptoms appear. The test has a sensitivity rate of 51% and specificity rate of 18%, indicating its potential for improving early detection of lung cancer.
A study at ESMO found gefitinib to be more tolerable and result in a greater likelihood of response in non-smoking Asian patients with adenocarcinoma of the lung. The targeted therapy is now considered a first-line treatment for this population.
Researchers found that patients with specific EGFR gene mutations can live almost two years on average when treated with erlotinib, outperforming chemotherapy by two-to-three fold. The study identified a subgroup of 15-22% patients who can benefit from targeted therapies
A narrow genetic region on chromosome 15 has been found to significantly increase the risk of familial lung cancer by 5.7- to 7.2-fold, regardless of smoking status. The study identified specific genetic variants associated with the increased risk and suggests they may be targeted for cancer therapies.
A study adjusting for a known bias in familial melanoma risk estimates reveals an increased relative risk of 3.18, with higher risks for young-onset cases. In contrast, the risks for colorectal, lung, breast, and prostate cancer remain relatively stable.
A new study by the American Cancer Society found that lung cancer death rates among never-smokers are highest among men, African Americans, and Asians in Asia. The review analyzed data from over 630,000 individuals and found that the incidence of lung cancer among lifelong nonsmokers is similar to brain and nervous system cancers.
A study of 2 million people and 22 cancer registries found that African Americans and Asians living outside the US have higher death rates from lung cancer than Europeans. Lung cancer risk among never smokers is not increasing, contradicting previous research.
Researchers developed a new model specifically for African-American populations, refining lung cancer risk prediction with unique results based on increased exposure to risks. The study also expanded the original Spitz model by adding DNA repair capacity measures, improving predictive capability.
Researchers have identified African-Americans as having a greater risk of developing lung cancer from chronic obstructive pulmonary disease (COPD), with a more than sixfold increased risk. Hay fever was also found to be protective among African-Americans, reducing the risk by 44%.
A study published in Journal of Consumer Research found that simply asking people if they're willing to volunteer their time leads to increased donations of both time and money. This effect cannot be explained by guilt or feelings of obligation, suggesting a deeper psychological connection between giving time and experiencing happiness.
A combination of S-1 and irinotecan appears to offer a promising alternative to standard treatment for advanced non-small cell lung cancer, with similar response rates and progression-free survival. The experimental therapy resulted in less severe side effects compared to platinum-based chemotherapy regimens.
A gene expression test could help determine which patients need more aggressive treatment, improving lung cancer survival rates. The study used a large dataset of lung cancer tissue samples to analyze hundreds of genes and predict patient outcomes.
Research suggests that passive smoking poses a significant risk to lung cancer development, with sidestream smoke potentially more carcinogenic than mainstream smoke. The study proposes using DNA-lesion footprinting and mutagenicity analysis to identify unique biological markers for assessing lung cancer risk in relation to SHS exposure.
Research finds that smokeless tobacco products carry a lower cancer risk compared to smoking, particularly for oral and oesophageal cancers. However, users are still at increased risk of other types of cancer, such as lung cancer, especially in countries with high STP use.
Smoke-free policies are reducing heart disease related to smoke exposure, prevalence of smoking in adults, and second-hand smoke exposure. These policies also increase smoke-free environments and have benefits for non-smokers.
A study published in The Lancet Oncology found that radiofrequency ablation can be an effective treatment for small lung tumors, with a confirmed complete response rate of 88% and overall survival rates ranging from 48-75%. The procedure was also shown to have a low risk of complications, including pneumothorax and pleural effusion.
A recent study published in The Lancet Oncology found that smoking does not increase the risk of lung cancer in women compared to men. However, women who have never smoked are at higher risk of developing lung cancer than men who have never smoked.
A new study suggests that CT lung cancer screening can increase lung cancer detection by 37% and reduce mortality by 28%, but has limited impact on all-cause mortality. Quitting smoking is still the most effective way to reduce risk of death from various causes.
A team of researchers from the University of Leeds has made a breakthrough in understanding finger clubbing by identifying its link to lung cancer. The team discovered that a genetic mutation prevents the breakdown of fatty compound PGE2, leading to swollen fingers and fingernails.
UCLA researchers found that smokers who ingested high levels of flavonoids had a lower risk of developing lung cancer. Flavonoids are water-soluble plant pigments with antioxidant and anti-inflammatory properties.
Researchers at the University of Pennsylvania's CEET have discovered that polycyclic aromatic hydrocarbons (PAHs) can lead to mutations in critical genes in lung cancer through oxidative stress. PAHs transform into oxygen free radicals, which bind to DNA and cause damage if not repaired.
A genetic disorder previously associated with lung disease may also increase lung cancer risk, according to a study. Researchers found that carriers of the disorder had a 70-100% increased risk of lung cancer compared to non-carriers.