Articles tagged with Lung Cancer
A new online database provides a comprehensive list of somatic EGFR mutations, allowing clinicians to make more robust decisions about treatment options for non-small-cell lung cancer patients. The database includes data from thousands of patients and offers improved treatment outcomes for those receiving tyrosine kinase inhibitors.
A study at the University of Texas M. D. Anderson Cancer Center found that oral tissue can be used to monitor molecular events in less accessible lung tissue. The research discovered that cells lining the mouth reflect the same antitumor genes silenced in oral and lung tissue, offering a new approach to detecting lung cancer.
Researchers found that nicotine increases osteopontin production, promoting cancer cell survival and spread. Elevated osteopontin levels have been detected in pancreatic cancer patients, suggesting a potential role in the cigarette smoking-pancreatic cancer connection.
A large-scale study has found a specific gene variant that increases the risk of lung cancer. The researchers also discovered a connection between this gene and nicotine dependence, as well as smoking behavior.
A recent study has identified two common genetic variants associated with an increased risk of lung cancer in smokers and former smokers. The variants, present in about half of the Caucasian population, were found to increase the risk by 28-81%.
Researchers at Boston University School of Medicine have developed a clinicogenomic model to test for lung cancer with increased sensitivity and specificity. The model combines gene expression and clinical risk factors, offering improved accuracy in identifying patients who would benefit from further invasive testing.
A new study published in Health Physics found that exposure to low levels of radon gas may reduce the risk of developing lung cancer, with a 60% reduction observed at certain levels. The study involved nearly 600 Massachusetts homes and adjusted for factors such as smoking and education.
Researchers at Yale University and Asuragen, Inc. found that the microRNA let-7 substantially reduced cancer growth in multiple mouse models of lung cancer, indicating a direct role for miRNAs in cancer progression. The study introduces a new paradigm for using miRNAs as effective therapeutic agents to treat human cancer.
Dr. Adam Marcus receives $80,000 award to study lung cancer cell invasion and mutations of the LKB1 protein. This research could lead to novel diagnostic and prognostic approaches to control lung cancer malignancy.
Two researchers, Hildegard Schuller and Albert Baldwin, received funding for studies on sex differences in lung cancer and the regulation of normal cell growth. The grants aim to increase understanding of lung cancer and support scientists pursuing lung cancer research.
AstraZeneca's investigational cancer drug vandetanib has completed patient enrollment in two pivotal Phase III studies for the second-line treatment of non-small cell lung cancer. The ZODIAC and ZEAL studies aim to assess the efficacy of vandetanib in combination with chemotherapy treatments.
Scientists have discovered specific methylation patterns in tumors and tissue that can predict which lung cancers are more likely to recur. These patterns could lead to reclassifying small lung cancers as advanced disease, allowing for more aggressive treatment options.
A study published by the American Thoracic Society found that certain vitamin supplements, including multivitits, vitamin C, and folate, did not protect against lung cancer and may even increase the risk. The risk was highest among current smokers, with a seven percent rise in risk for every 100mg/day of supplemental vitamin E.
Researchers identify hydrogen peroxide in cigarette smoke as a primary cause of lung cancer development. The study may lead to the development of 'safer' cigarettes and new treatments for lung cancer.
A University of Florida study found that the protein Bc12 blocks DNA repair in lung cancer cells, allowing them to thrive despite damage from radiation or chemicals. The discovery provides a new understanding of how lung cancer cells evade treatments, offering potential targets for drug development.
The National Lung Cancer Partnership has partnered with three organizations to co-sponsor new lung cancer research grants, focusing on survivorship care and nursing-sensitive patient outcomes. This move aims to address the lack of research funding for lung cancer, a leading cancer killer in the US.
Researchers at The Wistar Institute have solved the structure of p300/CBP, a gene regulator implicated in deadliest cancers. The breakthrough reveals how p300/CBP regulates a wide variety of genes and enables the development of targeted cancer therapies.
A multi-institutional study found PET more reliable than CT in characterizing lung nodules as malignant. PET's superior specificity led to correctly classifying 58% of benign nodules misclassified on CT.
A study suggests that endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) and its combination with endobronchial ultrasound-guided fine-needle aspiration (EBUS-FNA) can accurately determine lung cancer stage. These minimally invasive methods show high sensitivity rates, potentially replacing traditional surgical procedures.
Researchers at Mayo Clinic have developed a new technique using two small flexible tubes to stage lung cancer, achieving a 93% accuracy rate in finding malignant lymph nodes. This method is less invasive and more precise than traditional surgical methods, allowing patients to recover the same day.
A vaccine booster has been shown to induce a persistent immune response against lung cancer, reducing the risk of recurrence. The study found that patients who received regular recall injections experienced improved immunological memory, which can be strengthened with additional vaccinations.
Researchers at UCLA's Jonsson Cancer Center have discovered biomarkers that can help personalize treatment for patients with advanced non-small cell lung cancer. These biomarkers may identify patients who will respond to the Celebrex and Tarceva combination therapy, sparing them from ineffective treatments.
A $100,000 grant from Joan's Legacy will enable Cold Spring Harbor Laboratory to build upon recent lung cancer discoveries, focusing on epidermal growth factor receptors (EGFR) and their potential link to estrogen. The research aims to understand how EGFR genetic mutations contribute to non-small cell lung cancer development.
Scientists at UAB have identified a new lung cancer marker, AKR1B10, which can appear even before cancer develops. The enzyme's activity may play a role in the development of lung cancer and could be targeted by future treatments.
Researchers have identified a key gene, 14-3-3zeta, that enables lung cancer cells to survive on their own. Silencing this gene has been shown to inhibit the growth and survival of lung cancer cells, making it a potential target for selective anti-cancer drugs.
A study by Indiana University researchers found that receiving primary care during cancer treatment improves cancer survival rates, especially in lung cancer patients. Primary care utilization increased median survival rates by over fourfold, highlighting the importance of comprehensive care for whole-person health.
A new study published in PLoS Medicine found that consuming high amounts of red and processed meats increases the risk of developing bowel and lung cancer. The research, conducted by Amanda Cross and colleagues, analyzed data from a large US diet and health study involving nearly half a million men and women aged 50-71.
Researchers at Duke University Medical Center have identified four blood proteins that can distinguish patients with lung cancer from those without. The blood test, which uses a classification tree to sort out likelihoods, shows promise as a less-invasive follow-up for patients with suspicious lesions.
Researchers at M.D. Anderson Cancer Center link diet and gardening to lung cancer risk reduction, finding that smokers and nonsmokers can reduce their risk by eating four or more servings of green salad a week and working in the garden once or twice a week.
Researchers found that eating veggies, gardening, and being physically active can reduce lung cancer risk in smokers and non-smokers. Additionally, a study suggests men are more prone to developing skin cancers due to differences in antioxidant levels and DNA repair capacity.
A new study published in JCI Journal has found that CP-31398, a compound that binds to mutant forms of the p53 protein, can prevent and treat UV light–induced skin cancers in mice. The study also demonstrated that CP-31398 increased p53 function in human skin cancer cells expressing a mutant form of p53.
A five-year study will evaluate the performance of chest X-ray CAD in identifying hard-to-detect lung cancers, aiming to improve patient survival rates. The study, funded by the State of Ohio, will involve 9,000 test subjects and assess the software's ability to identify actionable pulmonary nodules.
A study by Dartmouth researchers found that rural patients are diagnosed at an earlier stage for colorectal and lung cancer compared to urban patients. The study controlled for various factors, including age, race, and education level. Rural-urban differences in cancer presentation may inform targeted screening efforts.
A comprehensive review by the UK National Health Service found that PET scans can help diagnose and treat certain types of cancer more accurately than other imaging technologies. However, it is unclear whether these advances lead to improved patient outcomes and survival rates.
Researchers found that urban colorectal and lung cancer patients present at later stages of disease than their rural counterparts. This study highlights the need for improved screening efforts in both rural and urban populations to address disparities in cancer diagnosis.
Researchers found that computer-aided detection (CAD) combined with multi-detector computed tomography (MDCT) improves radiologists' ability to detect solid lung nodules. CAD successfully matched 91.3% of nodules detected in both exams, and reduced reading time for radiologists.
The study provides a comprehensive view of the altered genetic background of lung adenocarcinoma, revealing new insights into its biology. The identification of the NKX2-1 gene highlights the importance of understanding the molecular properties of tumors to develop effective cancer diagnosis and therapy strategies.
Researchers at UCLA's Jonsson Comprehensive Cancer Center have discovered a novel mechanism to predict survival in older women with early-stage lung cancer. Higher levels of aromatase, an enzyme that produces estrogen, are associated with more aggressive disease and lower survival rates in women over 65.
A prospective study found that quality of life surpasses classic predictors like disease stage and tumor size in determining survival. Patients with better quality of life scores had a significantly higher rate of survival.
A study published in the Journal of the National Cancer Institute found that treatment with a vitamin A derivative called retinoic acid reduced the growth of lung cells in former heavy smokers. The researchers also found that the treatment slowed down cell growth in the parabasal layer of lung cells, but not in the basal layer.
Three studies investigate how tumors respond to EGFR inhibitors, revealing the crucial role of BIM protein in triggering apoptosis. The findings suggest that induction of BIM may lead to a new way of treating tumors resistant to these drugs.
Researchers found that PET scans at 3 months post-treatment can evaluate tumor response earlier and more accurately than current methods. Stereotactic body radiotherapy may be as effective as surgery in treating small tumors, but early detection is crucial to prevent treatment delays.
A new study published in CANCER found that despite significant increases in healthcare expenditures, survival rates for elderly patients with lung cancer remained relatively stable between 1983 and 1997. The average life-expectancy rose by less than one month, while costs increased by over $20,000 per patient.
Scientists identified DMP1 as a tumor suppressor that activates Arf expression, inducing p53-dependent cell cycle arrest. DMP1 deletion or haploid insufficiency accelerates lung cancer development in K-ras mutated mice and patients, suggesting its potential as a target for drug therapy.
Scientists have discovered a new gene, Dmp1, linked to human lung cancer, which is often deleted in lung tumors. The study found that the non-functional Dmp1 gene leads to reduced activity of tumor suppressors p53 and Arf, allowing cancer cells to grow unchecked.
The report found that cancer death rates declined by an average of 2.1 percent per year from 2002 to 2004, nearly twice the annual decrease of 1.1 percent per year from 1993 to 2002. Cancer incidence rates among American Indians and Alaska Natives varied two-fold across six geographic regions.
A study published in Thorax reveals a potential early warning system for lung cancer, detecting autoantibodies in blood that are associated with solid tumours and triggered by cancerous changes. The presence of these autoantibodies in patients indicates an 80% chance of a cure if the disease has not yet spread.
Researchers at CSHL have identified three genes causing 20% of lung cancers that interact to reactivate fetal gene expression patterns leading to tumor growth. Reversing these genes may lead to new treatment options for patients.
The NIBIB Quantum Grants program funds four innovative projects to develop new technologies for metastatic lung cancer diagnosis, bio-artificial kidneys, insulin-producing cells, and nanoparticles targeting brain tumors. These advancements aim to transform healthcare with potential breakthroughs in disease treatment and prevention.
A new study led by Duke University researchers found distinct differences in tumor susceptibility to chemotherapy drugs based on gene expression profiling. This allows clinicians to predict which patients are most likely to respond to standard therapy and offers alternative options for those not responding.
A study suggests that patients with non-squamous histology achieve statistically significant higher survival when treated with ALIMTA in the second-line setting compared to those with squamous histology. The analysis also identified other predictive factors for potential benefit from treatment, including adenocarcinoma histology and go...
Researchers have identified a panel of 15 genes that can serve as a biomarker for lung cancer, which may help identify individuals at high risk for the disease. The test, which analyzed gene activity in lung cells, showed a 96% accuracy rate in identifying lung cancer patients.
A new blood test has been developed to detect lung cancer in its earliest stage, promising improved diagnosis and treatment options. The test targets the Human Aspartyl (Asparaginyl) ß-Hydroxylase protein, which is abnormally expressed on the surface of cancer cells.
A third of prostate biopsies detected cancer, with the risk increasing with each subsequent biopsy. Gene variants influencing innate immunity also linked to improved or poorer lung cancer survival in white patients. Brain tumor stem cells susceptible to a cancer-killing virus, offering new treatment hope.
Research found knee monoarthritis in 296 patients (4.4%) with rheumatic disorders, a rare condition associated with operable non-small cell lung cancer. The disease is challenging to treat unless caught early, and the discovery provides new insights into potential early warning signs.
A common molecular pathway called retinoblastoma (RB) tumor suppressor could help predict which lung cancer patients will benefit from chemotherapy drugs. Researchers found that turning off the RB pathway resulted in an altered response to chemotherapy agents and more cancer cell death.
Researchers at UT Southwestern Medical Center have found that combining radiation therapy with the drug bavituximab significantly improves the effectiveness of lung cancer treatment. The drug targets tumor blood vessels by selectively binding to exposed phospholipids, signaling white blood cells to attack and destroy them.
Researchers developed a new technique that can detect specific chromosomal damage associated with lung cancer, which may indicate an increased risk. The study found significant differences in chromosomal abnormalities between never-smokers and high-risk smokers and patients with lung cancer.
Researchers identified genes that are irreversibly activated by smoking, leading to increased lung cancer risk in former smokers. The study's findings provide insight into why former smokers remain susceptible to lung cancer despite quitting.
Researchers found that taking vitamins and minerals did not reduce liver cancer death rates in a study conducted by the National Cancer Institute. However, some vitamin-mineral combinations reduced risk in subgroups defined by age, sex, and alcohol consumption. In contrast, gene expression patterns identified 11 genes in noncancerous l...