Articles tagged with Lung Cancer
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A study suggests that patients with non-squamous histology achieve statistically significant higher survival when treated with ALIMTA in the second-line setting compared to those with squamous histology. The analysis also identified other predictive factors for potential benefit from treatment, including adenocarcinoma histology and go...
Researchers have identified a panel of 15 genes that can serve as a biomarker for lung cancer, which may help identify individuals at high risk for the disease. The test, which analyzed gene activity in lung cells, showed a 96% accuracy rate in identifying lung cancer patients.
A new blood test has been developed to detect lung cancer in its earliest stage, promising improved diagnosis and treatment options. The test targets the Human Aspartyl (Asparaginyl) ß-Hydroxylase protein, which is abnormally expressed on the surface of cancer cells.
A third of prostate biopsies detected cancer, with the risk increasing with each subsequent biopsy. Gene variants influencing innate immunity also linked to improved or poorer lung cancer survival in white patients. Brain tumor stem cells susceptible to a cancer-killing virus, offering new treatment hope.
Research found knee monoarthritis in 296 patients (4.4%) with rheumatic disorders, a rare condition associated with operable non-small cell lung cancer. The disease is challenging to treat unless caught early, and the discovery provides new insights into potential early warning signs.
A common molecular pathway called retinoblastoma (RB) tumor suppressor could help predict which lung cancer patients will benefit from chemotherapy drugs. Researchers found that turning off the RB pathway resulted in an altered response to chemotherapy agents and more cancer cell death.
Researchers at UT Southwestern Medical Center have found that combining radiation therapy with the drug bavituximab significantly improves the effectiveness of lung cancer treatment. The drug targets tumor blood vessels by selectively binding to exposed phospholipids, signaling white blood cells to attack and destroy them.
Researchers developed a new technique that can detect specific chromosomal damage associated with lung cancer, which may indicate an increased risk. The study found significant differences in chromosomal abnormalities between never-smokers and high-risk smokers and patients with lung cancer.
Researchers identified genes that are irreversibly activated by smoking, leading to increased lung cancer risk in former smokers. The study's findings provide insight into why former smokers remain susceptible to lung cancer despite quitting.
Researchers found that taking vitamins and minerals did not reduce liver cancer death rates in a study conducted by the National Cancer Institute. However, some vitamin-mineral combinations reduced risk in subgroups defined by age, sex, and alcohol consumption. In contrast, gene expression patterns identified 11 genes in noncancerous l...
A nationwide survey found that nearly seven in ten Americans believe the risk of dying from cancer is increasing, despite clear evidence to the contrary. The study also revealed associations between sociodemographic variables, such as gender and education level, and the likelihood of believing false statements about cancer risks.
Researchers found a strong correlation between tumor responses during treatment and three months after completion, suggesting PET scans can be performed earlier to modify treatment plans. This could lead to better tumor control and survival rates, potentially changing standard practice guidelines.
Researchers have identified IL6 as a protein that stimulates tumor growth when activated by Ras, leading to increased blood vessel formation. Suppressing IL6 activity has shown promising results in fighting tumor formation in preclinical models.
Researchers found gene variations in interleukin 1A and 1B to be a major risk factor for lung cancer, particularly among heavy smokers. These variants can lead to an overzealous inflammatory response, causing genetic damage and cancer.
A recent study found that restaurant workers exposed to tobacco smoke have higher levels of NNK, a potent lung carcinogen. The researchers concluded that clean air exemptions are unjustified and policymakers should prohibit smoking in all indoor workplaces.
Cancer researcher Dimitrios Trichopoulos received a medal of honor from the World Health Organization's cancer agency for his work linking passive smoking to lung cancer. He has also explored the Mediterranean diet's role in reducing cancer and heart disease risk.
Researchers at UT Southwestern Medical Center have discovered how the compound beta-lapachone kills certain cancer cells, leading to a new paradigm for treating non-small cell lung cancer. Beta-lapachone interacts with an enzyme called NQO1, present in high levels in non-small cell lung cancer and other solid tumors.
Death rates from lung and bladder cancer remained high decades after residents in northern Chile were exposed to high levels of arsenic, indicating a clear pattern of latency in health effects. The study found that mortality risks continued to rise long after exposure ended, supporting the need for more testing of world's water sources.
A study found that arsenic exposure led to a significant rise in lung and bladder cancer deaths, with mortality rates peaking 10-20 years after exposure ended. The research suggests the need for controlling arsenic concentrations in drinking water worldwide.
Researchers found that talc stimulates healthy cells to produce endostatin, a hormone that inhibits tumor growth and kills tumor cells. The study reveals talcum powder's potential as a therapeutic agent for metastatic lung cancer, offering new hope for patients with incurable disease.
A multi-center team has discovered a 'signature' of proteins in the blood that predicts which non-small-cell lung cancer patients will live longer when treated with targeted therapies. The findings could help physicians decide which patients to treat with drugs known as EGF receptor tyrosine kinase inhibitors.
Research from Dana-Farber Cancer Institute reveals that Black Americans are less certain about lung cancer prevention recommendations and more fearful of symptoms evaluation, potentially delaying treatment. This fatalism may contribute to Black patients being diagnosed with advanced stages of the disease.
A new genomic test can identify specific patterns among thousands of genes to determine the precise pathways that led to lung cancer. Researchers found that tumors with defects in certain pathways responded well to targeted therapy, offering a potential alternative to traditional chemotherapy.
A study reveals that genetic differences in Japanese and US patients with non-small cell lung cancer affect how well they respond to chemotherapy drugs like paclitaxel and carboplatin. The research found that specific gene variations, such as CYP3A4 and ERCC2, influence treatment outcomes.
A Phase III study suggests ALIMTA-carboplatin may deliver less toxicity than GEMZAR-carboplatin, offering comparable quality-of-life benefits and survival data. The combination also appears to benefit from a lower toxicity profile.
A large Phase III study found that shark cartilage extract AE-941 has no benefit when combined with chemotherapy and radiation for patients with advanced non-small cell lung cancer. The study did not meet its primary endpoint: survival, and the researchers cast major skepticism on the efficacy of shark cartilage products.
A study of 519 patients found no benefit in overall survival from pre-operative chemotherapy for nonsmall cell lung cancer. Neo-adjuvant therapy did result in tumor down-staging and improved response rates, but its use should be targeted towards specific patient subgroups.
Two Lilly studies analyzed data from African-American and Hispanic patients with non-small cell lung cancer (NSCLC), suggesting race may not significantly impact treatment efficacy. The studies provided insight into the safety profiles of ALIMTA and GEMZAR in diverse populations, paving the way for further research.
A large observational study found that taking vitamin supplements does not decrease the risk of lung cancer. The study involved 77,738 men and women aged 50-76 and found no statistically significant relationships between supplements and lung cancer.
A large cohort study found that using Swedish moist snuff (snus) increases the risk of developing pancreatic cancer by twice the rate of non-users. The study, conducted on almost 300,000 male construction workers, suggests that while the risks are small, snus use can still be a concern for overall health.
Researchers have confirmed that tamoxifen prevents breast cancer in high-risk women, while a combination of three HER inhibitors slows down tumor growth. Additionally, chemotherapy with rituximab improves overall survival rates for patients with indolent lymphoma, and new lung cancer risk prediction models offer modest accuracy.
Researchers at University of Texas M. D. Anderson Cancer Center developed a lung cancer risk assessment tool using standard clinical and epidemiological data. The model assigns a score assessing a person's risk for the disease, with a prediction level of about 60 percent.
Researchers found that East Asians have lower levels of the EGFR protein, but those with lung cancer tend to have increased levels. This could explain why East Asians respond better to a certain type of chemotherapy.
The study found that lung cancer cells can become resistant to novel targeted agents by undergoing a miniscule molecular change in the EGFR protein. Researchers developed compounds to overcome resistance with innovative combinations of medications, which showed promise in preventing further resistance.
Researchers at the University of Texas M. D. Anderson Cancer Center have successfully delivered a cancer-suppressing gene into tumors of stage 4 lung cancer patients via an intravenously administered lipid nanoparticle. The gene, FUS1, was found to be active in metastatic non-small cell lung cancer tumors.
Researchers are developing gene therapies that can target and kill cancer cells, while also exploring the use of viruses and other natural systems to design new cancer treatments. Studies have shown promising results in animal models, including a novel gene therapy approach that eradicates aggressive prostate cancer.
Patients undergoing minimally invasive lung cancer surgery experience shorter hospital stays and accelerated recovery times compared to traditional open surgery. This approach also improves chemotherapy delivery, reducing delays and increasing treatment efficacy.
Researchers found that regular high-dose inhaled corticosteroid use among COPD patients lowered the risk of developing lung cancer. The study, published in the American Journal of Respiratory and Critical Care Medicine, found a significant reduction in relative risk for users of over 1,200 micrograms per day.
A lung cancer screening regimen has been found to identify patients with early-stage cancer, allowing for curative treatment. The study suggests that annual repeat screenings can detect lung cancer at its earliest stage, resulting in a high proportion of patients having no evidence of metastases.
A new study shows radiofrequency ablation effective for early-stage, inoperable lung cancer, achieving survival rates equal to or better than traditional external beam radiation. The treatment resulted in a 57% five-year survival rate and controlled tumor progression.
A recent study by Ohio State University researchers has identified a link between the absence of the Olig1 protein in lung tumors and poor survival rates among patients with non-small cell lung cancer. The findings suggest that patients with low levels of the protein may benefit from more aggressive therapy after surgery, potentially i...
According to a randomized controlled trial, radiation therapy is the preferred treatment option for patients with locally advanced stage IIIA-N2 non-small-cell lung cancer who have responded to chemotherapy. This finding suggests that surgery may not improve survival rates compared to radiation after chemotherapy treatment.
A blood pressure drug has shown potential as a new treatment for lung cancer, shrinking tumor volume by 30% in mice. The hormone angiotensin-(1-7) was found to reduce cyclooxygenase-2, an enzyme that regulates cell growth, and may provide a novel approach to treating the deadly disease.
Researchers studied two lung cancer-derived EGFR mutants and found distinct differences in inhibitor binding, leading to overactivation of the enzyme. The study suggests that specific mutants have unique targets for inhibition, potentially reducing toxicity and increasing effectiveness.
Scientists at Dana-Farber Cancer Institute mapped the structures of small molecules and mutated protein receptors in non-small cell lung cancer cells. They found that two inhibitors bind more tightly to specific mutations, potentially leading to more effective treatments.
A study found that computed tomography (CT) screening increased the rate of lung cancer diagnosis and treatment, but did not reduce the risk of advanced lung cancer or death. CT screening resulted in a 10-fold increase in lung cancer surgeries, which may be insufficiently beneficial to justify the morbidities.
A multi-center study found that CT screening for current and former smokers did not reduce deaths from lung cancer, despite finding nearly three times as many lung cancers. The study also found an increased risk of invasive procedures and unnecessary treatments due to false positives.
A new study published in the Journal of the National Cancer Institute found that female Chinese textile workers with high-level exposure to bacterial endotoxin have a 40% decreased risk of developing lung cancer. The researchers also noted that the protective effect was strongest for women exposed early in their career.
A scientific consensus on the link between smoking and lung cancer emerged in the mid-1950s, but tobacco industry efforts to sow doubt and delay regulation persisted. Proctor's research shows that consumer letters and phone logs reveal widespread ignorance about tobacco's health risks.
A new mouse model of non-small cell lung cancer validates MEK inhibitors as a potential treatment option. The model, developed by Dr. Martin McMahon and colleagues, shows that MEK inhibition can halt tumor progression in early-stage lung tumors.
Researchers found that never-smokers get lung cancer more often than thought, with women even more at risk. The study tracked over 1 million people and found significant differences in lung cancer incidence rates between males and females, shedding new light on the disease.
Research reveals that teenagers are more fearful of losing their sight than lung cancer or stroke, yet only a small percentage understand the link between smoking and blindness. The study found that just 5% of respondents correctly identified the risk, with even fewer among smokers.
A new study published in the American Journal of Public Health confirms the association between passive smoke in the workplace and an increased risk of lung cancer. Researchers found a 24% increase in lung cancer risk among people exposed to passive smoke, with highly exposed workers facing a 100% increased risk.
Researchers have discovered a new antibody that effectively regresses lung tumors in mice with two types of lung cancer driven by mutant forms of the EGFR protein. The study highlights the potential therapeutic benefits of this antibody, ch806, for treating patients with specific lung cancer mutations.
Researchers found that increased expression of HO-1 and administration of carbon monoxide protected mice from MS. In contrast, mice lacking HO-1 developed more severe disease. The study suggests modulating HO-1 expression or administering carbon monoxide may be useful therapeutic strategies for treating patients with MS.
Researchers developed a simple and non-invasive gene probe to diagnose early stage lung cancer in current and former smokers. The test identified 76% of stage I lung cancer patients whose tumors also showed the same genetic loss, outperforming existing sputum cytology tests.
Researchers at UT Southwestern Medical Center identified several genes whose expression is lost in lung, breast, prostate, and colon cancer. These findings could form the basis for a new early detection screen for certain cancers.
A new study found that supplements of Indole-3-carbinol provided significant protection against leukemia and lymphoma in young animals, as well as significantly protected against lung cancer later in life. The protective effects were found to come solely from maternal intake during pregnancy and nursing, and lasted into middle age.
A cost-utility analysis found that long-course palliative radiotherapy improved survival and quality of life in late-stage non-small-cell lung cancer patients. The study showed a $5,326 difference in lifetime societal costs between the two treatment regimens.
Researchers have discovered a new class of genetic mutations in the EGFR gene that occur in glioblastoma, a deadly type of brain tumor. These mutations, located in the extracellular domain of the protein, can activate oncogenically EGFR, making them a potential target for cancer therapy.