Articles tagged with Lung Cancer
Current and former smokers who used statins had lower lung function decline than those not using statins, regardless of smoking status. Statin use was found to decrease the decline in lung function by 10.3% in controls versus 1.3% in statin users.
Researchers at Johns Hopkins have found that lung cancer cells exploit the NRF2 gene to detoxify chemicals, including chemotherapy agents, rendering them ineffective. This discovery may lead to new treatment strategies by blocking NRF2 activity, potentially improving standard chemotherapy drug efficacy.
A study found that obese smokers have a 3.5 to 5 times increased risk of death compared to those of normal weight who never smoke. The study also revealed that being a current smoker is a stronger risk factor for cancer death than obesity.
Researchers found that a defective version of the NPRL2 tumor suppressor gene makes lung cancer cells resistant to cisplatin, a common chemotherapy drug. Gene therapy targeting this gene may restore sensitivity to cisplatin, offering new hope for treating resistant lung cancer.
A UK case control study found that living near heavy industry sites for over 25 years increases the risk of developing lung cancer. Women living in areas with high rates of poverty and industrial activity were more likely to develop the disease.
The National Institutes of Health has launched the first phase of The Cancer Genome Atlas (TCGA) project to study genomic changes in lung, brain, and ovarian cancers. The TCGA pilot project aims to identify key genomic alterations associated with cancer development and progression.
The Lung Metagene Predictor scans thousands of genes to identify patterns of gene activity in individual tumors, predicting a patient's likelihood of recurrence and recommending chemotherapy accordingly. The test has the potential to save thousands of lives each year by targeting high-risk patients with aggressive treatment.
Researchers at the University of Kentucky have developed a blood test to detect lung cancer in early stages, showing 90% accuracy in predicting non-small-cell lung cancer. The test identifies the body's immune response to tumors and could become the first blood test to predict cancer since the PSA test was introduced.
Researchers have found that nicotine stimulates cell proliferation and progression of tumors already initiated by tobacco carcinogens. The presence of nicotinic acetylcholine receptors on bronchial cells and lung cancer cells is key to this process, suggesting a new mechanism in lung cancer development.
A study published in JAMA found that women who smoke are more susceptible to lung cancer than men, with a higher rate of diagnosis. However, women tend to survive longer after diagnosis than men, with better survival rates for all major histological types of lung cancer.
Researchers found a novel tumor suppressor, HLJ1, that slows down lung cancer cell proliferation and reduces cancer recurrence. Patients with high HLJ1 expression lived longer than those with low expression.
A new study reveals that post-operative radiation therapy improves overall survival in select lung cancer patients whose disease has spread to regional lymph nodes. This is the first significant increase in survival rate since previous studies used outdated equipment.
A study published in the Journal of the National Cancer Institute found that screening for lung cancer can lead to overdiagnosis, resulting in unnecessary treatment and harm. The study suggests that mass screening may not be beneficial for public health due to the potential for overdiagnosis bias.
Researchers have discovered a new biomarker, ICAM, that can predict lung cancer treatment response and survival. Patients with low levels of ICAM had a higher response rate to treatment and significantly better overall survival rates.
Researchers found that a new 'disease control rate' measure was associated with survival, suggesting it could enhance efficacy assessment and improve clinical trials for advanced NSCLC. The study pooled data from 984 patients with advanced NSCLC who participated in three randomized trials of platinum-based chemotherapy regimens.
A phase-2 clinical trial found that Pfizer's oral drug, sunitinib malate, showed activity similar to other approved agents for non-small cell lung cancer, resulting in six confirmed partial responses and disease stabilization in 27 patients. The study also explored the effectiveness and safety of a continuous dosing strategy.
A new study by Dr. Ramalingam found that adding the drug vorinostat to standard chemotherapy improved outcomes for patients with advanced non-small cell lung cancer, with partial responses in 11 patients and disease stabilization in 7 more. The recommended dose of 400mg daily for two weeks was well-tolerated.
Researchers at UC Davis Cancer Center report a significant extension of survival in advanced lung cancer patients treated with bortezomib plus standard care. The median overall survival was 11 months, with one-year survival at 46%, offering promising results for this patient population.
Researchers have found that pairing Tarceva with Celebrex significantly increases response rates in lung cancer patients, offering a potential breakthrough in treating the disease. The combination therapy has shown to increase response rates by about three-fold, with some patients experiencing responses for up to 93 weeks.
A recent study identified 64 genetic variants associated with lung cancer development, including changes in proteins expressed by the genes. These findings suggest that a complex interplay between genetic and environmental factors contributes to lung cancer susceptibility, while tobacco smoke remains the leading risk factor.
A recent study by the American Thoracic Society found that marijuana smoking does not increase the risk of lung cancer or head and neck cancers. Heavy marijuana users, who smoked over 22,000 joints, did not have an increased risk of developing cancer.
Researchers engineered mice with mutated EGFR genes that can be turned on or off to study lung tumorigenesis and treatment responses. Mutations in EGFR drive lung tumors into regression by inhibiting the gene or turning it off.
A study of 940,000 adults found similar lung cancer death rates for men and women, but higher rates among African-American women. Never-smoking African-Americans may have a higher risk of lung cancer mortality compared to non-smoking whites.
A study found that 17% of patients with non-small cell lung cancer experienced a significant change in tumor size after just 31 days of chemotherapy. Tumors either grew or shrunk by 20-48% during this period, prompting changes to treatment plans.
A study by University College London found that middle-aged English people have lower rates of diseases such as diabetes, high-blood pressure, and lung cancer compared to their American peers. The differences were confirmed through analysis of biological markers, suggesting that the health disparities are not just due to reporting biases.
Researchers found that only 75% of studies met basic criteria for evaluation, highlighting the need for improved reporting in clinical trials. Meanwhile, a lung cancer risk model was found to underestimate actual rates over a 10-year period, while an enzyme-based approach shows promise in killing glioma cells.
Patients who never smoked showed improved response to chemotherapy and longer survival rates compared to former and current smokers. The finding may be attributed to non-smokers having less genetic damage and better preserved lung function.
A nationwide cohort of 3486 Swedish women who underwent cosmetic surgery for breast implants between 1965 and 1993 were followed until the end of 2002. The study found that women with implants had a reduced incidence of breast cancer and an increased incidence of lung cancer compared to the general population.
A new study by UC Davis Cancer Center researchers reveals that smoking is a significant contributor to cancer death rates among Asian Americans and Pacific Islanders. The study found that non-lung cancer death rates correlate closely with smoke exposures, suggesting that eliminating smoking could lead to very low cancer mortality rates.
Researchers developed a prototype model to gauge lung cancer risk based on medical history and genetics. The model predicts increased risk in heavy smokers with emphysema, as well as those with inefficient DNA repair capacity.
Researchers found that former smokers have higher CC10 levels than current smokers, which may help explain the lower risk of lung cancer among quitters. Additionally, first-degree relatives of never-smoking lung cancer patients are at increased risk of cancer and early diagnosis compared to healthy never-smokers.
A new study reveals that regular use of COX-2 inhibitors, such as celecoxib and rofecoxib, significantly reduces the risk of breast cancer. Women who used these drugs for at least two years experienced a 71% lower risk of breast cancer compared to non-users.
Researchers found a significant increase in cancer risk among first-degree relatives of lung cancer patients, particularly young onset cancers. The study's findings suggest that genetic factors play a crucial role in the development of lung cancer and other types of cancer.
Researchers at Duke University Medical Center are studying the interaction between genes and environment in promoting cancer. Environmental scientists have identified new culprits in the cancer equation, including chemicals that can damage or mutate genes, and epigenetic alterations that occur without changing a gene's fundamental code.
A UC Berkeley study found that children born with high levels of in utero arsenic exposure have a significantly higher risk of developing lung diseases such as bronchiectasis and lung cancer. The study, which analyzed death certificates from Chilean cities, revealed a 46 times higher death rate from bronchiectasis and seven times highe...
The American Association for Cancer Research (AACR) offers several awards and fellowships to support promising cancer scientists, including the AACR-GERTRUDE B. ELION CANCER RESEARCH AWARD, CAREER DEVELOPMENT AWARDS, and AACR-Cancer Research and Prevention Foundation Career Development Awards in Translational or Prevention Lung Cancer ...
A new screening method using cells in lung mucus can predict tumor development up to 18 months in advance. The test identified 65% of individuals who later developed symptoms of lung cancer, but also misidentified 35% of cancer-free participants.
A national analysis of local TV news health coverage reveals opportunities for improvement in accuracy and perspective. The study found that health and medical stories comprised 11% of late-evening newscasts, but often lacked specific information about disease prevalence and prevention methods.
A recent survey of 11,600 students in India found that sixth-grade students are using tobacco at a rate two to four times that of their eighth-grade peers. This trend suggests an initial wave of increased tobacco use among Indian youth, which warrants early intervention. The proportion of all deaths attributed to tobacco is expected to...
A study of 2337 lung cancer patients with advanced disease found that nearly 1% survived for five years after receiving low-dose palliative radiation therapy, including 18 who achieved an apparent cure. Prognostic factors were not found to predict survival in these patients.
Researchers found that high white blood cell counts were associated with an increased risk of cancer mortality, even after controlling for other factors. The association was strongest for lung cancer and suggested that aspirin may have a greater protective effect against cancer for those with high WBC counts.
Researchers found that bexarotene reduced tumor burden by almost 50% and inhibited malignant tumor progression by about 50% in mice. The study suggests bexarotene is a potentially viable lung cancer prevention candidate.
A study of 994 participants from north-east Belgium found a significant association between environmental cadmium exposure and an increased risk of cancer. The study, published in The Lancet Oncology, suggests that higher levels of cadmium in urine are associated with a doubling of overall cancer risk, including lung cancer.
A recent study published in Integrative Cancer Therapies found that dogs can detect breast and lung cancer with sensitivity and specificity rates of 88-97%. The trained dogs were able to identify cancers even in early stages, providing a potential reduction in uncertainty in cancer diagnosis.
A recent study suggests that individuals with a family history of lung cancer are at increased risk, with approximately a two-to-threefold higher chance of developing the illness. Researchers recommend identifying high-risk populations through data collection on family history and genetic susceptibility to facilitate targeted screening...
A study by Dana-Farber Cancer Institute found that black lung cancer patients are less likely to undergo surgery, despite equal access to care. The researchers attributed this disparity to a complex 'communications problem' underlying the interaction between doctors and patients.
A recent study published in the Journal of the National Cancer Institute found that screening chest x-rays can detect early-stage lung cancers at high rates. The study involved 77,465 participants and showed a significant reduction in lung cancer mortality among current smokers, with a detection rate of 6.3 cases per 1000 individuals.
A new study suggests a way to treat lung cancer in women, who are dying from the disease at higher rates than breast cancer. Researchers found that aromatase inhibitors can block estrogen-driven tumor growth in lung cancer cells.
A study of lung cancer patients found that those who did not participate in clinical trials were more likely to be African American, female, or over 70. The researchers suggest targeting specific patient subgroups to improve representation in clinical trials.
Researchers at the National Institute of Environmental Health Sciences discovered that the TLR4 gene plays a critical role in protecting against tumor development and chronic inflammation. This finding suggests targeting the innate immune system may be a useful tool in fighting various human diseases, including cancer.
A new study suggests that video-assisted thoracoscopic surgery can be a viable option for older patients with early-stage non-small cell lung cancer. The procedure has been shown to have low risk and good success rates, allowing patients to avoid the consequences of widespread cancer.
A new study published in Clinical Pharmacology and Therapeutics found that a nicotine vaccine was safe and well-tolerated in helping smokers quit. The vaccine, which works by producing antibodies that bind to nicotine, showed impressive results with 38% of participants quitting for at least 30 days.
A new study found that increased physical activity is associated with a decreased risk of breast cancer in both black women and white women, regardless of disease stage or family history. Additionally, research on plant compound deguelin suggests it may interfere with tobacco-induced lung cancer development, while high plasma levels of...
A new variant of retinoic acid receptor beta has been discovered, which may play a role in vitamin A resistance in lung cancer. The variant, RAR-beta-1', was found to be expressed in normal lung cells and sensitive to retinoic acid, but not in resistant or lung cancer cells.
A new antibody profiling technique has been developed to identify five protein markers that can detect lung cancer with high accuracy. The technique achieved 90% sensitivity and 95% specificity in identifying cancerous versus non-cancerous patient samples.
Researchers have discovered a protein, RAR1, critical for response to retinoid treatment, which is resistant to this class of drugs. By triggering RAR1 protein expression in cancer cells, sensitivity can be restored, offering new hope for lung cancer patients.
Studies identify molecular markers that can predict clinical outcome for patients with non-small cell lung cancer treated with gefitinib. Researchers found subgroups of patients with specific biomarkers, including EGFR gene copy number and Akt activation status, have increased survival rates.
A terminal cancer patient, D.H., has seen his cancerous tumors shrink to 10% of their original size after increasing his intake of omega-3 fatty acids. The nutritional intervention was part of a case study published in the Nutrition and Cancer journal, showing promising results for cancer treatment.
Patients with early-stage non-small cell lung cancer responded well to high doses of radiation administered through extracranial stereotactic body radiation therapy. The Phase I clinical trial treated 47 individuals with the procedure, which spared them from surgery and allowed for higher doses of radiation in a shorter period.
Researchers found that women with lung cancer have a significantly better cancer-specific, overall, and relative survival rate compared to men. In treated patients, women had a 54% lung cancer specific 5-year survival rate, while in untreated patients, women lived longer than men by 21%.