Articles tagged with Tuberculosis
A two-month course of therapy is an effective alternative to the year-long regimen for preventing active tuberculosis in HIV-infected individuals. The study found that fewer deaths occurred among patients in the two-drug arm, with improved treatment compliance compared to the one-drug arm.
Researchers found that using rapid diagnostic methods for M. tuberculosis can decrease diagnosis time from 38.5 to 23 days, time to therapy from 6.6 to 2.0 days, and mortality by 22-33%. This also reduces healthcare costs per patient.
Researchers discovered identical DNA fingerprints in bacterial cultures from two TB patients who were bronchoscoped at the same hospital. The study emphasizes the importance of maintaining TB DNA fingerprint registries to identify unsuspected transmission modes.
Researchers have created an efficient method to study Mycobacterium tuberculosis (TB) using transposon mutagenesis, allowing them to examine the effect of individual gene mutations on the bacteria's ability to grow or cause disease. This breakthrough enables the development of new drug targets and potential vaccine candidates.
Tuberculosis bacteria use the C2a protein to lure macrophages to their death, a strategy that makes them effective pathogens. Understanding this mechanism may lead to the development of a novel vaccine to prevent tuberculosis.
Researchers found that HIV-positive patients living in the eastern United States are at a higher risk of developing tuberculosis, particularly if they have low levels of CD4 cells. The study also revealed that nearly 25% of those diagnosed with TB died from the disease.
Researchers at Johns Hopkins have found that spending more time and money on strict drug regimens saves money in the long run. The cost-effective strategy, called directly observed therapy (DOT), cures more people sooner and decreases the risk of developing TB germs resistant to treatment.