Articles tagged with Allergies
Chronic mouth breathing can lead to abnormal facial and dental development, poor sleeping habits and academic performance. Treatment options are available, including surgical removal of tonsils and adenoids, and orthodontic intervention.
Scientists have identified a region of chromosome 5 associated with eosinophilic esophagitis (EoE), a rare allergic disease. The study suggests that the thymic stromal lymphopoietin (TSLP) gene may play a role in EoE, and future research may lead to a genetic test and treatments.
Researchers have identified a potential new set of targets to improve the efficiency of pancreatic islet transplantation. The study found that treatment with an antibody targeting HMGB1 prevented early pancreatic islet loss and inhibited IFN-gamma production by NKT cells and Gr-1+CD11b+ cells.
Researchers found that nasal allergies may be involved in some cases of chronic sinus disease, suggesting a potential link between the two conditions. The study suggests using imaging tests to diagnose and treat patients with nasal allergies who also have chronic sinus disease.
Researchers found that exposure to environmental bacteria triggers a mild inflammatory response in pregnant mice, rendering their offspring resistant to allergies. This protective mechanism could potentially prevent allergies in people by conditioning the developing immune system to tolerate microbes and allergens.
New research suggests that daycare attendance in early childhood doubles respiratory problems, but does not prevent later asthma and allergies. Children who started daycare early were more likely to experience wheezing in the first year of life, but this effect reversed by age eight.
A study found that traditional measurements and markers of inflammation were not effective in predicting future asthma symptoms and exacerbations in well-treated patients with persistent asthma. Researchers hope to identify better clinical predictors for this complex disease.
Dr. Tobias M. Hohl receives the 2009 ICAAC Young Investigator Award for his groundbreaking work on Aspergillus fumigatus and its interaction with the pulmonary innate immune system. His research has improved understanding of echinocandid mechanisms of action.
Researchers at the La Jolla Institute have identified a previously unknown role of an enzyme in suppressing tumor growth, which may lead to new treatments for myeloproliferative diseases and certain types of leukemia. The discovery could also provide insights into the mechanisms underlying blood cancers.
A controlled diet study with human volunteers found that a 2:1 w6/w3 ratio mimics early human diets can reduce inflammatory signaling genes. This study provides the first evidence of large changes in gene expression as a mechanism for omega fatty acids' clinical effects
A UCSF study found that personalized self-management programs for asthma patients significantly improved medication adherence and disease control. The program, which included a 30-minute session with a healthcare professional, resulted in better health outcomes and reduced emergency department visits.
Researchers have identified a gene variant on chromosome 11 that is linked to an increased risk of atopic dermatitis, a chronic inflammatory skin disease. The study found that this variant is also associated with Crohn's disease and affects approximately 36% of the European population.
A study at the University of Gothenburg reveals that over 5% of individuals tested are allergic to linalool, a fragrance ingredient in many hygiene products. The risk increases with exposure, and EU legislation requires labeling of products containing linalool.
A new screening tool developed by Tel Aviv University researchers may help doctors advise young asthmatic adults on safer employment options and prevent asthma attacks triggered by physical exertion. The study found an indisputable connection between exercise and asthma, which could save lives.
REGiMMUNE receives significant funding from Japan's JST and NIBIO to advance its immunosuppressant ToleroVax for GvHD and allergy treatment reVax. The grants will support preclinical and clinical programs for these promising therapies.
A new study identifies specific characteristics of immune cells called CD8+ T cells that successfully destroy HIV-infected cells. These cells are able to load granules with proteins necessary for delivering a death-inducing molecule called granzyme B to infected cells.
Researchers found that allergy symptoms may protect against cancer by removing foreign particles and substances from organs that come into contact with them. However, the relationship between asthma and lung cancer is a special case where asthma actually increases lung cancer rates.
Sequella has received a $2.3 million NIH grant to develop SQ641, a promising new TB drug that demonstrates superior in vitro activity against Mycobacterium tuberculosis. The Phase 2 SBIR grant will fund critical path studies for delivery optimization and IND-related activities.
Researchers found that children with allergic rhinitis are more likely to experience headaches, facial pain, and ear aches. The study suggests that these symptoms may be under-appreciated sources of discomfort for many children, leading to reduced diagnoses and effective treatment.
Research led by the University of New South Wales found that individuals with atopic diseases such as asthma and hay fever are up to 40% less likely to develop NHL if they have multiple conditions. Chronic atopy is associated with a reduced risk, particularly in B-cell NHL cases.
The prevalence of allergies has increased, with patients facing inadequate specialist care and resources. Community pharmacists are suggested as a solution to bridge the treatment gap, according to a recent editorial in The Lancet.
A study published in the American Journal of Respiratory and Critical Care Medicine found that traffic-related pollution increases the risk of asthma, hay fever, and eczema in children by more than 50%. Children living closer to roads are at a higher risk due to increased exposure to pollutants and aerosols.
Recent studies suggest that specific immunotherapy can be an effective treatment for allergies, reducing symptoms and adverse reactions. The Institute also found that certain measures, such as quitting smoking and taking probiotics during pregnancy, may help prevent allergies in children.
Dr. Anthony S. Fauci, director of NIAID, will be honored with the Presidential Medal of Freedom for his decades-long work on HIV/AIDS research and treatment. The award recognizes his efforts to advance human knowledge and bring hope and healing to millions worldwide.
A new study finds that air pollution from sulfur dioxide, fine particles, and nitrogen dioxide can cause decreased lung function and increase asthma symptoms in inner-city children. The study suggests that current air quality standards may not be sufficient to protect these vulnerable populations.
A nationwide survey of children's health shows significant disparities in healthcare for minority kids, including unequal access to medical services, higher rates of asthma, hearing and vision problems, diabetes, and dental care. These disparities may have long-term effects on the health of these populations.
A new TB drug, SQ109, has been given special status by the US and European regulators for its potential to combat drug-resistant strains of M. tuberculosis. The orphan designation will accelerate clinical testing of the drug, which may lead to simpler and more effective treatment regimens for the disease.
People with a history of allergies have a nearly third lower risk of developing certain brain cancers, such as glioma. Meanwhile, genetic studies identified three locations on human chromosome 8q24 associated with an increased risk of prostate cancer.
Dr. Thomas E. Wellems is being honored by the American Society for Microbiology (ASM) for his groundbreaking research on malaria treatment and resistance to chloroquine. His work has significantly impacted malaria treatment, leading to a decrease in death rates in Africa and Asia.
A recent study led by McGill University found that breastfeeding does not offer protection against childhood asthma and allergies. The research, which followed 13,889 children from birth to age 6½, revealed an increased risk of positive allergic skin tests among breastfed infants.
Researchers at LIAI demonstrated that retinoic acid regulates inflammation in laboratory mice, affecting pro-inflammatory T cell lineages. This finding suggests a new avenue of therapies using retinoic acid to treat autoimmune diseases.
The NIAID Research Agenda for Multidrug-Resistant (MDR) and Extensively Drug-Resistant (XDR) Tuberculosis (TB) identifies six critical areas for investigation, including new diagnostics, therapy, and vaccines. The agenda aims to close gaps in understanding MDR/XDR TB and improve clinical management, particularly for people with HIV/AIDS.
A survey of European parents found that cows' milk allergy affects not only the child but also the entire family unit, causing stress, guilt, and sleep deprivation. The condition can lead to a range of symptoms, including skin rashes, gastrointestinal issues, and respiratory problems, making it challenging for families to cope.
A study published in Journal of Allergy and Clinical Immunology found that exposure to cat allergens at home increases the frequency of allergic sensitization in young children. The study analyzed data from over 1,000 children born between 1997 and 1999 and found that even brief contact with cat hair can lead to sensitization.
Researchers have developed a new diesel exposure model that improves accuracy in assessing air pollution risks, particularly for children. The model takes into account complex factors such as elevation and traffic volume to create 'buffers' around specific sample sites.
Two trials found HIV acquisition rates to be 53% and 51% lower in circumcised men compared to uncircumcised men in Kenya and Uganda, respectively. The Lancet published the findings on adult male circumcision as a prevention strategy for HIV.
A new study by Cincinnati researchers found that children of allergy sufferers are more likely to develop allergic sensitization at a younger age. The study suggests reevaluating skin testing practices for airborne allergens in infants under 4 or 5 years old.
Researchers found that histamine receptor overactivation may cause low blood pressure during exercise recovery, leading to fainting. Antihistamine use before exercise significantly reduced post-exercise hypotension in a study.
The National Institute of Allergy and Infectious Diseases (NIAID) has awarded a $998,325 grant to Berkeley Lab's Kenneth Raymond to develop new agents for large-scale radiological treatment. The goal is to test these agents with animals and proceed to clinical trials within 18 months.
The NIAID has awarded five grants totaling up to $4 million to fund the development of products that eliminate radioactive materials from the human body. The goal is to accelerate the development of previously identified compounds into effective products for licensing in the strategic national stockpile.
Patients with allergic rhinitis experience more difficulty sleeping and sleep disorders compared to those without allergies. Allergic rhinitis affects about 20-50% of the population, contributing to snoring, breathing problems, and sleep apnea.
The study found that childhood allergy prevalence increased globally, with higher rates in Asia-Pacific and India. The prevalence of eczema was highest in young children, while hayfever showed increases across both age groups.
Researchers at Mayo Clinic have discovered an association between allergic rhinitis and the development of Parkinson's disease. The study found that people with allergic rhinitis are 2.9 times more likely to develop Parkinson's, highlighting a potential link between inflammation and the disease.
Infants exposed to 20 or more cigarettes a day are three times more likely to develop allergic rhinitis by their first birthday. Environmental tobacco smoke puts harmful particulates in the air that can lead to serious allergic conditions like asthma.
A study of over 6,600 children found that those raised in Steiner schools had lower rates of allergic symptoms and diagnoses compared to non-Steiner peers. Early antibiotic use and vaccinations were linked to increased allergy risks.
The updated practice parameter provides new definitions for acute, subacute, chronic, and recurrent sinusitis, as well as guidelines for diagnosis and treatment. Antibiotics should be used judiciously, and referral to an allergist/immunologist is recommended for patients with chronic or recurrent sinusitis.
Patients under the care of an allergist reported significantly fewer asthma control problems, less severe symptoms, and higher satisfaction with their care. This study suggests that specialist care can lead to better outcomes for patients with chronic asthma.
The American Academy of Allergy, Asthma & Immunology recommends regular assessment of asthma control to ensure patients receive optimal treatment. This approach helps identify changes in medication effectiveness and environmental triggers.
A new focus for asthmatics aims to control the condition, rather than letting it control them. Asthma treatment should be individualized and tailored to achieve target symptom control, with regular visits to doctors for reassessment and medication adjustment.
Researchers have identified a protein in the smallpox virus that elicits a strong human antibody response, providing potential protection against the lethal virus. The discovery could lead to the development of an effective treatment for smallpox, offering immediate protection to individuals at risk.
The study found a cellular protein called HVEM acts as an 'off and on switch' for immune responses, enabling communication between T lymphocytes and other cells. This discovery could lead to new treatments for autoimmune diseases by mimicking HVEM's action.
Rokach's research focuses on designing and synthesizing radio- and photo-affinity ligand molecules to bind to the disease-causing enzyme, which contributes to asthma, inflammatory bowel disease, and psoriasis. The grant will support his work on identifying the structure of the enzyme.
Researchers at UTMB discovered that oxidative stress from pollen is as important as antigen exposure in triggering severe respiratory inflammation. Antioxidant substances may help forestall allergy or asthma attacks, and longer-lived antioxidants could be effective in treatment and prevention.
Research suggests that certain genetic variations associated with asthma and allergies may lower the risk of glioblastoma multiforme (GBM), the most common type of brain cancer. The study found that individuals with specific polymorphisms on two genes, IL-4RA and IL-13, had a lower GBM risk.
Plant pathologists warn that SBS is a complex problem requiring objective inspections for possible causes. Mold growth and dust are two of the main contributors to SBS, necessitating the expertise of more plant pathologists and mycologists.
Dr. Albert Z. Kapikian receives the Sabin Gold Medal for developing the first licensed rotavirus vaccine, saving millions of lives worldwide. His pioneering work in electron microscopy and virus characterization has been widely recognized by NIAID Director Anthony Fauci and H.R. Shepherd.
Researchers found that high levels of oxygen can exacerbate lung inflammation in mice by triggering the release of adenosine, a molecule that protects against tissue damage. The study suggests that adenosine substitutes may be useful in preventing lung damage in patients with acute lung inflammation.
A recent study by Dr. Irene Leal-Berumen and colleagues reveals that asthma patients' immune systems exhibit distinct responses to allergens depending on the presence or absence of allergic rhinitis symptoms. The findings have significant implications for the development of personalized treatment therapies.
A recent study found that indoor allergen levels vary significantly across the country, with cockroach allergens exacerbating asthma symptoms in inner-city children. Exposure to dust mite allergens was not found to have a significant impact on asthma symptoms.
A NIAID-sponsored clinical trial is enrolling healthy adults to assess the immune response and safety of the Fluarix vaccine, which has been distributed in over 70 countries. The trial will provide valuable information on the vaccine's efficacy before it can be licensed for use in the US.