Articles tagged with Cell Invasion
A study confirms mitochondrial deficits in children with autism, which affect the functioning of granulocytes and lead to increased oxidative stress. The findings suggest that deficiencies in energy metabolism may contribute to cognitive impairments associated with autism.
Researchers discovered that p53 acts to prevent cancer cell invasion by initiating a chain of events that ultimately prevents the formation of lamellipodia. This process involves the activation of a mitochondrial protease called Omi, which cleaves actin filaments and suppresses the activity of focal adhesion signaling protein p130Cas.
Researchers at LA BioMed developed antibodies to prevent human cell invasion and treat mucormycosis using CotH protein blocker. The study provides groundwork for developing therapies and diagnostic tests for high-risk patients.
Researchers have identified phosphatases in human cells that are involved in bacterial survival and found small molecules that can stop them from working. This approach jams the host cell machinery rather than directly attacking the bacteria, potentially reducing the risk of resistance development.
Researchers discovered that tension on gut muscles induces cell invasion in zebrafish intestine, a process similar to cancer metastasis. The study identified invadopodia formation as the key driver of this process, which is triggered by oxidative stress.
Human HLA genes are evolving rapidly, improving disease-fighting abilities but complicating organ transplant matching. The vast number of variants makes it unlikely to identify a perfect match through worldwide searches.
Researchers have identified enzymes and biochemical compounds that target the dengue virus, suggesting a potential new therapy. Medications used for high cholesterol may also inhibit the virus's replication.
A mutation on the surface of human red blood cells provides protection against malaria caused by Plasmodium vivax. Research found that the parasite binds less easily to cells expressing a specific variant of the Duffy blood group antigen, reducing the risk of infection.
Scientists at Brigham and Women's Hospital create a platform approach that incorporates homing receptors onto cell surfaces to target specific tissues. This enables more efficient cell-based therapies by increasing the concentration of cells at target locations in the body.
A research team led by Bradley Davidson discovered that specialized structures in sea squirt cells, called invadopodia, may help cancer cells evade elimination processes. In contrast to cancer cells, sea squirt cells use these structures to pick up chemical signals for development, not invasion.
Researchers discovered that many proteins are required for maximum toxicity of ricin and PE, with differing requirements at multiple levels. Understanding toxin trafficking may lead to designing treatments targeting these toxins and potential synergistic therapies.
Researchers at Duke University Medical Center have discovered a possible new treatment for idiopathic pulmonary fibrosis (IPF) by targeting the invasive type of cell that leads to lung fibrosis. By reducing the production of hyaluronan and blocking its receptor, they were able to prevent fibrosis in living mice.
A study published in Immunity describes a mechanism by which an infected cell can alert neighboring uninfected cells, leading to amplified inflammation and enhanced immunity. This 'cell-to-cell communication' strategy enables the host to circumvent immunosuppressive bacterial activity and defeat invaders.
Preliminary research published in Gut suggests that plantain and broccoli fibers may prevent the translocation of E. coli across M-cells, a key stage in Crohn's disease development. The study found that plantain and broccoli fibers reduced E. coli translocation by 45-82%, while leek and apple fibers had no effect.
Researchers from the University of Montreal have identified an enzyme called NOX2 that generates highly reactive oxygen derivatives to activate defense genes and molecules against viral invasions. The study reveals how these free radicals serve a critical role in mounting an immune response to viral infections.
Researchers found that ALDH-positive tumor cells have a worse prognosis and are more likely to proliferate and invade compared to ALDH-negative cells. ALDH-positive cells were detected in 90% of primary surgical specimens and were associated with shorter overall survival.
The SRC-3 gene enhances breast cancer growth and invasion by activating cell motility, allowing cancer cells to invade surrounding tissue. Researchers found that the gene enables an alternative form of its coactivator protein to function at the cell membrane, leading to increased cancer spread.
Researchers at LSUHSC have identified miR-27b as a major player in the development of invasive breast cancer, found to stimulate cell growth and invasion. Meanwhile, ST14 gene suppresses tumor cell growth and may serve as an early detection marker for breast cancer.
Researchers have identified MEK4 as a key player in promoting cell invasion in prostate cancer. Genistein, a dietary compound, inhibits MEK4 kinase activity, suggesting potential therapeutic applications for prostate cancer treatment.
LSUHSC researchers discovered that excessive IQGAP1 production weakens cell-to-cell contacts, promoting cell migration and invasion. The study provides insights into the prolonged activated state of Cdc42, a key protein involved in cancer spread.
FAK coordinates movement of migrating cancer cells by balancing the number of invadopodia that create a path for migration and the number of focal adhesions that hold the cell back. In its absence, breast cancer cells sprout extra invadopodia and form large, sticky focal adhesions.
A new species of microsporidia has been discovered in a roundworm, providing a powerful system to study these mysterious microbes and develop new drugs. The discovery is particularly exciting as it offers a unique opportunity to identify new treatments for human microsporidian infections.
Researchers confirm that bacteria responsible for UTIs are entrenched inside human bladder cells, contradicting previous models. The finding confirms the importance of fully understanding bacterial behavior in the bladder to develop better diagnoses and treatments.
Researchers at Harvard Medical School have discovered a new type of programmed cell death called entosis, where cells bore into their neighbors and died. This process, known as entosis, was found to be more common in cancerous cells than previously thought, and its role in tumor progression is still unclear.
Biologists used simple equations to describe the motion of Listeria monocytogenes, reproducing all observed shapes with just two variables. The equations can help identify bacterial mutants and rule out mechanisms driving the motion.
A new task for IgG has been discovered, helping cells capture germs and dispose of them. The antibody aids in the formation of phagolysosomes that kill off invading microbes.
Researchers at Vanderbilt-Ingram Cancer Center have identified a crucial link between the CXCR4 receptor and the invasion of glioblastoma, a type of aggressive brain tumor. By inhibiting this receptor, experts hope to develop new treatments to prevent cancerous cells from spreading to other organs.
Scientists have identified a new mechanism by which Listeria invades non-phagocytic cells, revealing similarities between phagocytosis and endocytosis. Researchers found that Listeria uses endocytosis to transport tagged proteins inside the cell.
A team of researchers has identified an intermediate stage in virus-cell fusion that lasts several minutes, providing a potential window of opportunity for drug development. This discovery may allow existing drugs to be re-evaluated and fine-tuned to target this critical point in the viral entry process.
Researchers have watched infectious prion proteins invade and move within brain cells, shedding light on transmissible spongiform encephalopathies (TSE) diseases. The findings may lead to ways to prevent or minimize their effects.
A Rutgers-Newark scientist has found that mosquitoes may carry a lethal parasite called B. algerae, which can invade human muscle tissue and cause death. The parasite is typically found in the tissues of mosquitoes and can be transmitted to humans through mosquito bites.
E. coli bacteria undergo four distinct developmental stages during UTIs, including a quiescent state that may create reservoirs for recurrent infections. Researchers hope to use these stages as guides for new drug development.
Researchers found endostatin treatment reduced invasive head and neck cancer cells by half and their migratory capabilities by one-quarter. The study suggests an implanted drug delivery system could provide sustained therapeutic drug levels directly to tumors.
Scientists have found a way for single-celled organisms like Tetrahymena to protect themselves against harmful invaders by co-opting their attributes. This system, discovered by Martin Gorovsky and Kazufumi Mochizuki, helps regulate the cell's genome and prevent disastrous effects from genetic mutations.
Researchers developed an Intrakine blockade to block a specific chemokine receptor, leading to reduced inflammation and modulated immune responses in various disease models. This breakthrough could provide new therapeutic avenues for treating conditions like asthma, autoimmune diseases, and cancer.