Articles tagged with Kupffer Cells
A study found that reshaping the gut microbiome with antibiotics can significantly reduce liver clearance and double chemotherapy delivery to tumors. This approach has potential as a strategy to enhance nanoparticle-based cancer drugs.
A new study finds that macrophages, the liver's cleanup specialists, quickly adapt after injury to clear debris and support tissue recovery. The research highlights the dynamic nature of these cells during liver injury and repair, offering promising implications for future therapies.
This study reveals the molecular mechanisms underlying heat stroke-induced liver injury, focusing on heme oxygenase 1 and its role in ferroptosis in specific Kupffer cell subsets. Targeted therapy against HMOX-1 has the potential to mitigate inflammation and alleviate acute liver injury.
Researchers found that Kupffer cells in liver respond to high cholesterol by removing excess, revealing the liver's role in regulating cholesterol levels. This discovery suggests atherosclerosis is a systemic disease affecting multiple organs.
The study highlights the importance of spatially-resolved macrophage phenotyping in liver diseases. Macrophages exhibit functional and phenotypical heterogeneity, affecting disease progression.
Researchers have discovered a new mechanism of immune surveillance by liver-resident macrophages called Kupffer cells that prevent liver metastasis from escaping. They successfully cleared tumors in various animal models using a new method for in situ targeted expression and remodels of KCs' anti-tumor function.
Researchers at MUSC found that fungal infections are common in cirrhosis patients, often resistant to antibiotics. Patients with cirrhosis are immunocompromised and need proactive infection management.
A study by Kanazawa University researchers found that the chemokine CCL3 plays a significant role in inducing inflammation as nonalcoholic fatty liver disease develops. The presence of CCL3 increased liver macrophage accumulation, leading to liver inflammation and scarring.
Scientists have identified a polymer with fine-tuned mobility properties that alter the immune activity of specific liver cells, offering potential for regenerative medicine. The study found that surface mobility significantly affects the movement and gene expression profile of Kupffer cells.
Researchers developed NicheNet, a method to analyze intercellular communication, using machine learning and statistical techniques. The tool helps gain insight into how gene expression is regulated by interacting cells, with potential applications in immunology and tumor biology.
A study from University of California - San Diego outlines a fundamental process for liver macrophage specialization, enabling future research into macrophage malfunction's contribution to liver disease. The team identified key genetic and molecular changes that occur during the two-week differentiation process.
Scientists from TWINCORE published insights on processes involved in liver inflammation, highlighting the importance of Kupffer cells in regulating inflammatory responses. Type I interferons trigger Kupffer cells to take up infected cells and undergo apoptosis, while also delaying regeneration of immune cells.
B cells circulating through the liver are first depleted after treatment with anti-CD20 antibodies. The study reveals a vital role of liver Kupffer cells in deleting B cells and provides techniques to improve the effectiveness of anti-CD20 therapy.
Researchers developed a novel approach to isolate high-quality RNA from Kupffer cells, overcoming technical obstacles. The method uses laser capture microdissection with India ink labeling, resulting in enriched mRNA and significant gene expression changes.
Researchers investigated Kupffer cell dynamics and phagocytic activity in a rat NASH model, confirming the effectiveness of CEUS examination in diagnosing NASH. The contrast effect in the liver parenchymal phase using Levovist® strongly implicates Kupffer cells in NASH pathogenesis.