A new study found that higher levels of PFAS in the blood are linked to an increased risk of early onset of metabolic dysfunction-associated steatotic liver disease (MASLD) in adolescents. MASLD affects up to 40% of children with obesity and increases long-term risk for type 2 diabetes, heart disease, and liver cancer.
A new study links gut dysbiosis to severe steatosis in MASLD, improving diagnostic accuracy when microbiota status is added to standard clinical tools. The inflammation-linked Bact2 enterotype is strongly associated with severe hepatic steatosis in MASLD.
Researchers discovered that RvD2, a specialized proresolving lipid mediator, can alleviate established liver scarring or fibrosis. Treatment with RvD2 improved liver histopathology and increased bone marrow and blood monocytes.
This study explores the molecular mechanisms of steatosis-to-NASH progression using two mouse models and identifies genes, non-coding RNAs, proteins, and plasma metabolites involved. GDF3 is found to be up-regulated in NASH mice and serves as a potential non-invasive diagnostic biomarker for NASH patients.
A study using gadoxetate disodium-enhanced MRI found associations between imaging characteristics and hepatocellular adenoma (HCA) subtypes. The algorithm identified common HCA subtypes with high accuracy, including β-catenin exon 3 mutations.
The study reveals that SARS-CoV-2 infection alters hepatocyte metabolism towards glycolysis, while impairing mitochondrial activity, leading to liver damage. Metformin is proposed as a potential therapeutic option to attenuate SARS-CoV-2 infection in patients with fatty liver.
Researchers have identified Insulin like growth factor 2 mRNA binding protein 2 (IGF2BP2) as a key regulator in the development and progression of nonalcoholic steatohepatitis. IGF2BP2 overexpression was found to induce liver steatosis, inflammation, and injury in healthy mice, while knockdown improved NASH pathogenesis.
A multicenter study found that only 42% of patients with a visualization score C on surveillance exams maintain the same score on follow-up exams. The study suggests that alternative surveillance strategies may be necessary for patients at risk for HCC, particularly those with severe steatosis and advanced cirrhosis.
A diet rich in green leafy vegetables, especially those high in inorganic nitrate like spinach and rocket, may prevent liver steatosis. Researchers found that increased nitrate intake reduced fat accumulation in the liver and improved insulin/glucose homeostasis in mice with type 2 diabetes.
A large retrospective study found that nonalcoholic fatty liver disease (NAFLD) independently contributes to increased atherosclerosis and cardiovascular mortality. Patients with fatty liver were more likely to develop carotid plaques over time, highlighting the need for thorough cardiovascular and metabolic work-ups in NAFLD patients.
A large study found that fatty liver disease is common among liver transplant recipients, with a significant increase in prevalence over time. The condition is linked to various risk factors, including high body mass index, elevated blood triglycerides, and type 2 diabetes, but does not affect short-term patient survival.
A study by German researchers discovered a link between the PNPLA3 gene and liver cirrhosis in Caucasian alcoholics, revealing that those carrying a specific genetic variant may be at a higher risk of developing the condition. The study found that up to 50% of these high-risk individuals may progress to cirrhosis.
A new index of adipose dysfunction, visceral adiposity index (VAI), is directly correlated with viral load and independently associated with steatosis and necroinflammatory activity in patients with G1 CHC. VAI score also linked to insulin resistance, fibrosis, and moderate-severe necroinflammatory activity.
A study investigated the link between high ferritin levels and steatosis in a non-obese cohort of non-alcoholic patients, finding hyperferritinemia as a surrogate marker of advanced liver disease. The research suggests that high ferritin levels are associated with low platelet count, steatosis and clinical relevance.