Articles tagged with Inhibitory Effects
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Researchers discovered diverse types of inhibitory neurons that filter messages to neighbors, enabling precise control over brain activity. This design principle allows for complex and fine-grained inhibition, potentially leading to novel treatments for neurological disorders.
Researchers at McGill University have developed a new vaccine approach to block molecules that prevent nerve regeneration in spinal cord injuries. The technique showed significant regrowth of nerve fibers, outperforming previous methods.
Researchers at UT Southwestern Medical Center designed and tested synthetic inhibitors against telomerase, a key enzyme in cancer cell immortality. These inhibitors successfully caused progressive telomere shortening and cell death in human breast and prostate cancer cells.
Rheumatoid arthritis patients receiving a single dose of Alexion's 5G1.1 showed significant reduction in joint pain and symptoms compared to placebo-treated patients, with 50% achieving an ACR20 score. The company is currently enrolling up to 200 patients in a Phase II efficacy trial employing multiple doses of 5G1.1.
Omapatrilat, a vasopeptidase inhibitor, has been shown to improve cardiovascular function and reduce death rates and hospitalization for worsening heart failure. The drug may offer a potential breakthrough in treating congestive heart failure, which kills over 44,000 annually.
Researchers at UCLA and Human Genome Sciences have discovered two human proteins, METH-1 and METH-2, that inhibit blood vessel formation and show promise in treating a range of cancer tumors. The proteins were found to be more potent than endostatin in preventing new blood vessel growth.
The report in Science reveals the x-ray crystal structure of MMP-2, a key target for anti-cancer drug candidates. The elucidated structure provides valuable information on the function and regulation of MMP-2, enabling the design of improved inhibitors.
Research found that pollutants in house dust, such as PAHs, can enhance the inhibitory effect of chlorpyrifos on cholinesterase, a critical enzyme for nerve cell function. The study suggests that exposure to these pollutants may increase pesticide toxicity, posing health risks to humans.
Researchers have found that butyltins can disrupt the function of human natural killer cells, which are critical in fighting tumor cells and infected cells. The study's findings highlight the need for further research into the potential health effects of these chemical contaminants on humans.
Marie Filbin's research discovery reveals a way to overcome the inhibiting function of MAG and other molecules that prevent axon regrowth after injury. By priming neurons with neurotrophins, she reverses inhibition and enables regeneration.
Researchers found that COX-2 inhibitors suppress prostacyclin, a hormone-like substance produced in blood vessels, which can lead to increased thrombosis risk. This discovery raises concerns about the potential cardiovascular risks of these new pain relievers.
Research by Japanese scientists found that beer inhibited the action of mutagens caused by suspected cancer-causing compounds, with stout beers showing the most potent effect. The study also showed that red and white wines, brandy, and Japanese sake had similar inhibitory effects.
Dynavax's proprietary ISS-DNA alters immune response in allergic asthma, inhibiting symptoms and modifying inflammation. The company believes ISS-DNA therapy may provide a novel treatment for chronic allergic pulmonary inflammation.
Researchers at UT Southwestern Medical Center have discovered how aspirin reduces inflammation by targeting a specific kinase. Aspirin inhibition prevents NF-kB activation and suppresses inflammation, making it an excellent target for developing novel anti-inflammatory agents.
UB researchers found that a minor plant-based fat called B-sitosterol enhances an intracellular signaling system that tells cells not to divide, inhibiting prostate-cancer cell growth. The study showed a 28% inhibition of cancer-cell growth after five days in vitro.
Researchers found that the fen-phen diet drug combination was potentially toxic due to the destruction of serotonin control in blood plasma. This could lead to primary pulmonary hypertension and heart valve lesions in some users. The study highlights the importance of complete and up-to-date drug labels.
Researchers found that aspirin inhibits angiogenesis in tumor cells by blocking COX-2 enzyme production, which prevents the formation of blood vessels. Additionally, aspirin also targets COX-1 enzyme in endothelial cells, forming new blood vessels.
Researchers at Jefferson Medical College have found a way to inhibit the hepatitis B virus by blocking its envelope creation, resulting in a dramatic drop in viral levels. The discovery may provide new leads for treating chronic HBV and HCV infections in humans.
Researchers have made rapid progress on a new class of anti-cancer drugs that target the Ras protein activation pathway, which causes up to 90% of pancreatic cancers. Laboratory studies have shown effective inhibition of cancer cells using FTase inhibitors.
A study found that soy protein with phytoestrogens significantly reduced atherosclerosis progression in postmenopausal monkeys, similar to mammalian estrogen therapy. The treatment also improved cholesterol profiles, including increased HDL levels and reduced LDL/VLDL levels.
A recent MGH study found that only 31% of patients with heart failure were prescribed ACE inhibitors in 1994, despite their proven effectiveness in reducing death and disability. The study suggests a lack of knowledge and unrealistic assessments may contribute to the underprescription of these medications.
Researchers have discovered that individual neurons in the brain can be compared to tiny computers that analyze and integrate information from different sources. These findings have implications for improving hearing aids, sonar devices, and speech recognition systems.
A new study found that ACE inhibitors increase patient survival by about 30 percent overall, especially in patients with impaired heart function. The analysis supports the use of ACE inhibitors in almost all patients with impaired heart function when discharged from hospital following a heart attack.
Researchers at the University of Pennsylvania School of Medicine have identified a molecular target of action for BRCA1, which induces the cell cycle inhibitor p21. This finding suggests potential strategies for treating breast and ovarian cancers, including screening drug compounds to activate p21.
Scientists have discovered how p27 blocks cell growth in virtually all human cancers, providing new hope for developing drugs to halt uncontrolled cell division. The discovery uses X-ray crystallography to reveal the molecular structure of p27 and its interaction with cyclin-CDK complexes.