Articles tagged with Peptides
A new MIT technique involves growing cartilage cells within a novel gel, which is then delivered to damaged joints. The engineered tissue has mechanical and biochemical properties similar to native cartilage.
A new method to prevent HIV from infecting healthy cells has been discovered by a team of researchers at the University of Illinois. The study found that reverse-chirality D-peptides can block the virus's entry into cells, providing a potential new therapeutic option.
Researchers create custom-built antimicrobial agents using polymers and oligomers inspired by natural defense peptides. The new approach focuses on overall shape rather than specific chemistry, offering a novel solution for combating bacterial infections.
New drug targets have been identified by Buck Institute researcher Vivian Hook, Ph.D., that could help treat Alzheimer's Disease. The targets participate in producing the toxic beta-amyloid peptide, which accumulates to form plaques in the brain.
Researchers have synthesized peptide mimics that may inhibit Pin1's action, which regulates cell division. The goal is to develop new anticancer therapies by targeting the cell-cycle-regulating enzyme Pin1.
A team of UB researchers has discovered a novel peptide in human saliva with potent antimicrobial activity against various types of bacteria and fungi, including drug-resistant strains. The peptide, labeled MUC7 20-mer, shows activity at very low concentrations and little toxicity to mammalian cells.
Researchers have found a new, hidden piece of the influenza virus that may kill immune system cells. This protein was discovered by accident while studying
Researchers have developed optimized antiviral peptide vaccines that exhibit enhanced efficacy against various viral infections, including HIV and SARS-CoV-2. These improvements are attributed to the incorporation of specific amino acid sequences that enhance immune responses.
A phase II study found that DiaPep277 treatment maintained insulin production in patients with early type 1 diabetes. The treatment also reduced the need for insulin therapy and altered immune response patterns.
A bacterial peptide has been identified as a key regulator of host responses to infection. This discovery opens up new avenues for the development of therapies targeting this process.
A secreted mitochondrial peptide regulates vascular tone by acting on the endothelial nitric oxide synthase, leading to increased NO production and vasodilation. This peptide also modulates the activity of other key enzymes involved in vascular relaxation.
Dr. Brian L Bray's innovative approach enables mass production of T-20, a 36-amino acid peptide blocking HIV entry. The process opens up new possibilities for peptides as therapeutics and may treat millions of Americans with HIV.
A new DNA-based cancer treatment has shown promise by targeting and eliminating tumor cells. Researchers have discovered that DNA vaccination can place tumors in a state of immune activation, making them more susceptible to attack.
Researchers develop a technique to conjugate peptides to virus-like particles, generating high-titer antibodies that inhibit disease-causing cytokines. This approach shows promise in blocking or delaying onset of autoimmune diseases such as arthritis.
Researchers at Scripps Research Institute develop cyclic peptide nanotubes that disrupt bacterial cell walls, killing deadly pathogens. These 'nanotube' stacks have strong bactericidal activity and may minimize resistance development.
Researchers analyze kinetics of amyloid b1-40 peptide clearance in mice brains, finding vascular transport is primary mechanism. They also suggest ApoE plays role in amyloid clearance pathway.
Jan Lohmann and Thomas Bosch report a discovery of the novel peptide HEADY, which acts as a potent inducer of head formation in lower metazoans. Grafting experiments show that HEADY induces a secondary head in Hydra tissue, revealing its role as a developmental switch for axis specification.
A study published by Emory University researchers found that a naturally occurring neurotransmitter called CART peptide produces behaviors associated with cocaine and methamphetamine. The finding suggests a role for the brain chemical in modulating or mediating the actions of drugs and potentially treating addiction.
Researchers have identified a sequence of amino acids found in fibronectin that accelerates healing of hard-to-treat skin wounds in obese, diabetic mice. The substance completely healed skin puncture wounds in eight days, compared to 20-42 days in untreated diabetic mice.
Researchers discovered a direct link between apoE and cerebral amyloid angiopathy (CAA), a leading cause of bleeding strokes in the elderly. Decreasing apoE expression may inhibit CAA buildup, lowering the risk for cerebral hemorrhage.
Researchers identify a component of Chilean tarantula venom that specifically blocks stretch-activated channels, implicated in various physiological processes. This peptide toxin shows promise in treating conditions such as congestive heart failure, heart attacks, and brain tumors.
The journal features novel approaches to analyzing complex peptides, such as pramlintide, and developing injectable implants for sustained drug release. Liposomes are also explored as carriers for antimicrobial peptides like Leucinostatin A.
Researchers developed a non-toxic peptide that prevents metastatic prostate cancer from spreading to other organs in laboratory rats. The peptide, PHSRN, was effective even when primary tumors were allowed to grow before treatment began.
Researchers discover a method to find peptides that mimic antibodies by binding to specific peptide epitopes, opening up new possibilities for biomedical research and medical diagnostics. The discovery could lead to more field-practical sensors to detect biowarfare agents and other applications.
Scientists found that pituitary adenylyl cyclase-activating peptide (PACAP) works in concert with glutamate to adjust the body's internal clock. Bright light at night triggers the release of both molecules, which convey information about light properties to the brain.
Researchers at the University of Illinois have isolated and characterized an insulin gene from the marine mollusk Aplysia californica. The study reveals a unique peptide, the 'D' peptide, which is separated from the standard two-chain insulin structure by a 'C' peptide.
Researchers have developed a new family of chemicals that bind specifically to the gp41 pocket, halting HIV's ability to infect cells. The compounds, created using mirror-image phage display, show promise as potential oral treatments for HIV, with advantages including reduced cell membrane penetration and lower likelihood of resistance.
Scientists used peptide injections to divert the immune system and prevent disease progression in mice with type-I diabetes. The study suggests peptide-based immunotherapy may be effective for people at risk of developing the autoimmune disease.
Researchers found that a small peptide, IM862, showed significant anti-angiogenesis activity in a human clinical trial, resulting in major responses in 37% of patients. The peptide inhibits blood vessel formation and modulates the immune system, offering a potential treatment for Kaposi's Sarcoma with improved safety profiles.
Northwestern University researchers have identified key peptides that can halt and even reverse kidney disease in lupus. The peptides were found to be effective in delaying the onset of severe kidney disease in young mice and prolonging survival in adult mice with established kidney disease.
Researchers discover the structure of a key compound enabling the bacterium's deadly mechanism and create molecules that block its effects in mice. The study provides a novel way to combat Staphylococcus aureus infections without killing the bacteria, potentially addressing antibiotic resistance.
A Purdue University study shows that proteins can replicate themselves and adapt to changes, expanding the scientific view of how life began. The study also found that changes to the environment affect the types of peptides that can be formed.
Scientists have identified peptides substance P and neurokinin A as key components in the body's pain responses. The study suggests that these peptides work together to produce moderate-to-severe pain, offering a potential target for new pain treatments.
Researchers have developed molecular sensors that can detect specific proteins in blood plasma or other biological fluids with high accuracy. The sensors could also be used to construct an environmental detector, giving new insights into cell functioning and promoting medical diagnostics.
Researchers discovered a molecule, ERAB, that causes early neuron damage in Alzheimer's disease. The finding may lead to therapies that inhibit the interaction of ERAB and amyloid-B peptide, protecting neurons from damage.
Researchers at Johns Hopkins Medicine discovered a peptide that closes an NMDA glutamate receptor, potentially aiding the development of stroke treatment drugs. The peptide, known as Mag-1.5, can help regulate communication between nerve cells and may provide insights for potential new therapies.
A new vehicle has been found to carry therapeutic proteins into living cells, overcoming a major hurdle in the delivery of protein-based drugs. The discovery uses small peptides to substitute for bulky components of bacterial toxins and deliver therapeutic proteins into cells.