Articles tagged with Peptides
Researchers found that aerobic training can reverse abnormal production of certain neurohormones that cause severe symptoms of heart failure. The study suggests that exercise may be a novel non-pharmacological aid for improving functional capacity, systolic function, and quality of life in heart failure patients.
The pHLIP peptide accumulates in cell membranes at low pH and translocates molecules into cells without relying on traditional entry pathways. This technology has potential applications in imaging, diagnosis, and treatment of diseases associated with acidic environments.
A new targeted drug has been developed to prevent long-term changes in brain cells that contribute to addiction. The peptide works by tricking cellular machinery into pulling the glutamate receptor back onto the surface, restoring normal communication between neurons.
Researchers have developed a method to modify collagen, allowing it to be used in new medical treatments such as preventing blood clots and scar tissue. The modified collagen can also be used to deliver drugs and control the shape of engineered tissue.
Researchers have found that oxytocin plays a key role in regulating food intake in response to dehydration, but its impact may vary depending on the situation. Studies have shown that dehydration anorexia is virtually absent in mice genetically engineered to eliminate oxytocin.
A new molecule Pep1 has been isolated from Arabidopsis thaliana, a plant species favored for experimentation, and found in various crop species. The Pep1 peptide regulates pathogen defense in plants, increasing their resistance to diseases and enhancing overall growth.
Research reveals peptide signals play a key role in information processing, influencing complex behaviors such as sexual and social behaviors. Alpha-MSH effects male sexual behavior by stimulating oxytocin release from dendrites, changing brain circuitry.
Researchers find HIV domains mediate cell membrane fusion and downregulate T-cell responses. The study also suggests a novel way to decrease undesirable immune responses, independent of HIV infection.
Researchers at UCLA have discovered a 'molecular zipper' structure in proteins linked to Alzheimer's, Parkinson's and mad cow disease. The discovery provides a potential rational basis for developing drugs to fight these diseases.
A newly discovered 'branding' process in immune system cells may help the immune system determine which infections to fight, potentially leading to new vaccine strategies. The discovery also sheds light on autoimmune conditions such as rheumatoid arthritis and type 1 diabetes.
Researchers have identified a protein piece that can attach to polypyrrole, a synthetic polymer, allowing for the development of implantable devices that stimulate nerve growth. The breakthrough could lead to new treatments for nerve damage and tissue engineering applications.
Scientists have discovered a way to bio-synthesize an anti-cancer compound using a microbe found in sea squirts. The study, published in PNAS, reveals that the Prochloron microbe produces two patellamide compounds, which can be produced through biosynthesis without destroying large numbers of sea squirts.
Researchers have created a new method to identify specific proteins in bacterial cells, simplifying the process and increasing signal-to-background ratio. The technique uses peptide mass fingerprinting with mass spectrometry, allowing for rapid identification of target proteins amidst hundreds of other cell components.
A study by Cardiff University found that males with attractive body odor produce peptides that increase their sexual attractiveness to females. The research suggests that smell plays a crucial role in choosing a partner, particularly for humans and fish, and may be linked to immune genes.
Research found that enriched mice had lower levels of b-amyloid peptides, which form toxic brain tangles in Alzheimer's disease. The enrichment act as a protective factor, keeping peptide levels low before they can aggregate and cause problems.
Dr. Walsh will focus on his research on nonribosomal peptide synthetases, which biosynthesize a variety of biologically active peptides. He will discuss the molecular logic of enzymatic assembly lines and tailoring enzymes that modify the peptides.
Researchers have developed a peptide vaccine that produces an immune response in 60% of patients with myeloid leukemia, resulting in complete molecular remission for three patients. The vaccine targets the PR1 peptide, which is overexpressed on leukemia cells, inducing immune T-cells to kill cancer cells while leaving normal cells intact.
Researchers used computer simulations to visualize the formation of amyloid fibrils, similar to those found in Alzheimer's and Parkinson's patients. The study suggests that understanding how these fibrils form could lead to discoveries of how to slow or halt their growth.
A UK researcher has made significant breakthroughs in understanding the mechanisms of Alzheimer's disease. The study found that methionine in the human amyloid beta peptide is a key contributor to the disease, causing damage to neurons and decreased cell viability.
Researchers have found that carbonyl sulfide forms peptide bonds spontaneously, addressing a long-standing question in the origin of life. The discovery suggests that this chemical component may have played a significant role in the emergence of life on Earth.
Researchers at MIT and partners successfully integrated a photosynthetic protein complex with a solid-state electronic device, paving the way for efficient energy generation. The innovation uses spinach chloroplasts to create a dry environment that stabilizes protein complexes, enabling the development of practical organic solar cells.
Researchers developed a novel peptide compound that triggers apoptosis in cancer cells, overcoming key obstacles associated with short peptides. The hydrocarbon-stapled alpha-helix peptide, SAHB, is more resistant to degradation and can be taken up by cells, making it a promising therapeutic agent.
A new technique developed by researchers at the University of Toronto has shown promise in guiding nerve cells to repair spinal damage. By using a series of fibrous rods with peptides, the team aims to stimulate cell adhesion and migration, bridging gaps between severed spine ends.
Researchers at the University of Pennsylvania have created a library of small protein-like molecules that can self-assemble to form hollow corkscrew-like pores. These man-made pores can mimic biological function, filtering out unwanted molecules from solutions or carrying specific molecules across cellular membranes.
A study by University of Wisconsin-Madison assistant professor Stephen Gammie found that low levels of corticotropin-releasing hormone (CRH) trigger maternal aggression in mice, enabling them to protect their offspring. The results show that increasing CRH levels reduces maternal aggression and increases fear responses.
A new study published in the Proceedings of the National Academy of Sciences found that leptin triggers production of áMSH, a powerful peptide signal that boosts metabolism. This discovery could lead to the development of obesity treatments that increase energy production and promote weight loss.
Researchers found three to four times more antibodies in Alzheimer's patients than healthy individuals, indicating a possible autoimmunity component to the disease. This discovery may lead to an early diagnostic test and more targeted treatments.
Researchers found that cross-priming, a key mechanism in T-cell activation, is directly correlated with the levels of whole proteins expressed by virus-infected cells. This new information could lead to the development of vaccines effective against infectious diseases such as HIV/AIDS and malaria.
A new study published in Science proposes a potential design principle for vaccines targeting difficult-to-destroy viruses like HIV and smallpox. The research found that a double-punch approach, targeting both pathways to activate killer cells, could provide more efficient protection against viruses.
CZEN-002 demonstrated anti-infective and anti-inflammatory properties, with 88.2% of subjects showing efficacy in potassium hydroxide tests and mycological cultures. The treatment was well-tolerated with no significant changes from baseline vital signs.
Researchers found that increased expression of ADAM10 reduced AB peptide formation and prevented plaque formation in an Alzheimer disease mouse model. This suggests that targeting alpha-secretase might be a useful therapeutic target for AD.
Researchers create peptide coatings that disguise particles, allowing them to track proteins in live cells. This technology enables molecular-level studies and has potential applications in biology, medicine, and electronics.
Scientists at Johns Hopkins Medicine have overcome a major obstacle to creating large libraries of drug-like peptides. By modifying naturally occurring amino acids with a methyl group, they can produce up to 10 billion stabilized peptides in a single reaction. This breakthrough enables the rapid testing of potential medicines and has s...
The Proteomics Shared Resource at OHSU enables faster and more precise protein identification, processing up to 180 samples in six hours. The lab's advanced technology, including a robotic arm and mass spectrometer, helps researchers analyze proteins and identify their composition.
Scientists have engineered a tobacco plant to produce a toxin derived from the defense system of the flesh fly, which has shown promise in repelling parasitic weeds. The toxin, sarcotoxin IA, is produced only where the parasite attacks the host and accumulates more on the parasite than on the host.
A peptide, MUC7 12-mer, has shown promise for treating drug-resistant fungal strains. When combined with a protease inhibitor cocktail, its anti-microbial action was significantly increased.
The study, published in Pharmacological Reviews, reveals that activation of certain melanocortin receptors can modulate the inflammatory process, reducing major molecules involved. This discovery has implications for treating localized and systemic inflammatory disorders, including organ transplantation and chronic inflammatory diseases.
Researchers developed a novel tumor cell-specific therapy that restores p53 protein function in cancer cells. This approach eliminates tumors and increases animal survival by up to six times, offering promising implications for targeted therapies.
Researchers used AFM to study the effects of two monoclonal antibodies on beta amyloid peptide aggregation. The m266.2 antibody effectively inhibited protofibril formation, suggesting a promising approach for understanding conformational diseases like Alzheimer's.
Biomedical engineers at Purdue used dip-pen nanolithography to create templates on retinal tissue, which can potentially improve transplant strategies for macular degeneration. The research aims to enhance the success of implanting retinal pigment epithelial cells as a treatment for this incurable eye disease.
Researchers found that CART peptide, a natural brain chemical, reduces the effects of cocaine by reducing locomotor activity. The discovery opens doors to develop potential treatment options for cocaine addiction.
Researchers found that CART peptide reduces the effects of cocaine on rodents, leading to a decrease in locomotor activity. They plan to study the mechanism of action and explore its potential as a treatment for cocaine addiction in humans.
A new peptide-based vaccine has shown promising results in treating advanced melanoma by inducing a strong immune response in patients. The vaccine, which includes granulocyte macrophage-colony stimulating factor (GMCSF), resulted in significant tumor regressions and stable disease in some patients.
Researchers found that Peptide T significantly reduced HIV levels in cellular reservoirs, with some participants experiencing undetectable virus and increased CD4 counts. The therapy showed promise as a complement or alternative to existing treatments for HIV/AIDS.
Researchers at UCSD have identified two peptide sequences that bind to abnormal beta-amyloid plaques in Alzheimer's disease. The peptides may be used for diagnostic tests or coupled with molecules to inhibit plaque toxicity, making them a promising new approach to the disease.
Researchers developed a novel computer protein design method that created a more efficient and stable version of the peptide Compstatin, which prevents autoimmune-mediated damage. The new method cut down on trial and error, allowing for faster development of potential biopharmaceuticals.
Researchers discover a new class of proteasome inhibitors that change the shape of the protein-digesting enzyme, leading to reduced activity and selective protein degradation. This finding has implications for treating diseases such as heart disease and cancer.
Researchers discovered that four peptide hormones from the heart inhibited DNA synthesis and tumor cell growth in laboratory tests, outperforming a standard drug used to treat pancreatic cancer. The findings suggest these naturally-occurring hormones may hold promise as an alternative treatment option with fewer side effects.
Researchers at Purdue University have obtained the first-ever images of a developing dengue virus, revealing a complex developmental process that could lead to the discovery of new antiviral medicines. The immature particle is covered with protein spikes that flatten out as it matures into the infectious dengue virus.
Researchers have successfully used syngeneic hematopoietic stem cell transplantation to prevent autoimmune diabetes in mice, providing a promising new approach for treating genetic disorders. This breakthrough is made possible by the discovery of natural gene therapy mechanisms that can reverse mutations causing rare inherited diseases...
Studies found that patients with acute brain injury had lower levels of anti-inflammatory molecule a-MSH, which remained low over four days after injury. This impairment may have detrimental consequences for brain injury treatment.
A Pennsylvania chemist has won a prestigious national award for his groundbreaking work on peptides, which have the potential to revolutionize the treatment of neurological conditions. The researcher designed lactams, chemical bridges that stabilize peptides and make them less digestible to enzymes.
Researchers investigating a potential new treatment for type 1 diabetes found severe allergic reactions in mice, raising concerns about its safety. The study's findings contrast with earlier mouse studies suggesting the treatment could reduce incidence of diabetes, and highlight the need for cautious evaluation of immunotherapy research.
Researchers at Zengen developed a 'super peptide' that kills Candida albicans with high candidacidal activity, outperforming existing antimicrobial peptides. The discovery may help understand the unique mechanism of action of a-MSH peptides and unlock new treatments for fungal infections.
Researchers have found that delta opioid peptide may help protect brain cells from the ravages of Parkinson's disease by inducing a state of suspended animation. The compound was shown to reduce brain damage and neurological deficits in animal models of stroke, suggesting potential benefits for patients.
Researchers at the University of Illinois have created synthetic cytochromes by designing a small cyclic peptide that binds to iron millions of times more strongly than without it. This peptide's unique structure enables it to facilitate electron transport across cell membranes, potentially leading to effective antibiotics.
The study identifies five insulin-like peptides that regulate mosquito life cycle and disease transmission, providing new targets for genetic interference. The discovery could lead to the development of more effective control methods against malaria.
Scientists study emesis in genetically engineered mice lacking specific PDE4 subtypes and infer that inhibition of PDE4D mediates nausea. The discovery could lead to the development of selective PDE4 inhibitors with anti-inflammatory effects, reducing side effects in humans.
Researchers have identified a protein fragment in cereal grains that causes celiac sprue, an autoimmune disorder requiring strict gluten-free diets. A bacterial enzyme that breaks down this peptide may also offer relief to those with the condition, according to a study published in Science.
Researchers at Ohio State University have developed a peptide treatment that inhibits experimental autoimmune encephalomyelitis (EAE) and suppresses the onset of multiple sclerosis-like symptoms. The treatment targets T cells by binding to CD80, preventing their activation and expansion in disease.