Articles tagged with Peptides
The study, published in Pharmacological Reviews, reveals that activation of certain melanocortin receptors can modulate the inflammatory process, reducing major molecules involved. This discovery has implications for treating localized and systemic inflammatory disorders, including organ transplantation and chronic inflammatory diseases.
Researchers developed a novel tumor cell-specific therapy that restores p53 protein function in cancer cells. This approach eliminates tumors and increases animal survival by up to six times, offering promising implications for targeted therapies.
Researchers used AFM to study the effects of two monoclonal antibodies on beta amyloid peptide aggregation. The m266.2 antibody effectively inhibited protofibril formation, suggesting a promising approach for understanding conformational diseases like Alzheimer's.
Biomedical engineers at Purdue used dip-pen nanolithography to create templates on retinal tissue, which can potentially improve transplant strategies for macular degeneration. The research aims to enhance the success of implanting retinal pigment epithelial cells as a treatment for this incurable eye disease.
Researchers found that CART peptide, a natural brain chemical, reduces the effects of cocaine by reducing locomotor activity. The discovery opens doors to develop potential treatment options for cocaine addiction.
Researchers found that CART peptide reduces the effects of cocaine on rodents, leading to a decrease in locomotor activity. They plan to study the mechanism of action and explore its potential as a treatment for cocaine addiction in humans.
A new peptide-based vaccine has shown promising results in treating advanced melanoma by inducing a strong immune response in patients. The vaccine, which includes granulocyte macrophage-colony stimulating factor (GMCSF), resulted in significant tumor regressions and stable disease in some patients.
Researchers found that Peptide T significantly reduced HIV levels in cellular reservoirs, with some participants experiencing undetectable virus and increased CD4 counts. The therapy showed promise as a complement or alternative to existing treatments for HIV/AIDS.
Researchers at UCSD have identified two peptide sequences that bind to abnormal beta-amyloid plaques in Alzheimer's disease. The peptides may be used for diagnostic tests or coupled with molecules to inhibit plaque toxicity, making them a promising new approach to the disease.
Researchers developed a novel computer protein design method that created a more efficient and stable version of the peptide Compstatin, which prevents autoimmune-mediated damage. The new method cut down on trial and error, allowing for faster development of potential biopharmaceuticals.
Researchers discover a new class of proteasome inhibitors that change the shape of the protein-digesting enzyme, leading to reduced activity and selective protein degradation. This finding has implications for treating diseases such as heart disease and cancer.
Researchers discovered that four peptide hormones from the heart inhibited DNA synthesis and tumor cell growth in laboratory tests, outperforming a standard drug used to treat pancreatic cancer. The findings suggest these naturally-occurring hormones may hold promise as an alternative treatment option with fewer side effects.
Researchers at Purdue University have obtained the first-ever images of a developing dengue virus, revealing a complex developmental process that could lead to the discovery of new antiviral medicines. The immature particle is covered with protein spikes that flatten out as it matures into the infectious dengue virus.
Researchers have successfully used syngeneic hematopoietic stem cell transplantation to prevent autoimmune diabetes in mice, providing a promising new approach for treating genetic disorders. This breakthrough is made possible by the discovery of natural gene therapy mechanisms that can reverse mutations causing rare inherited diseases...
Studies found that patients with acute brain injury had lower levels of anti-inflammatory molecule a-MSH, which remained low over four days after injury. This impairment may have detrimental consequences for brain injury treatment.
A Pennsylvania chemist has won a prestigious national award for his groundbreaking work on peptides, which have the potential to revolutionize the treatment of neurological conditions. The researcher designed lactams, chemical bridges that stabilize peptides and make them less digestible to enzymes.
Researchers investigating a potential new treatment for type 1 diabetes found severe allergic reactions in mice, raising concerns about its safety. The study's findings contrast with earlier mouse studies suggesting the treatment could reduce incidence of diabetes, and highlight the need for cautious evaluation of immunotherapy research.
Researchers at Zengen developed a 'super peptide' that kills Candida albicans with high candidacidal activity, outperforming existing antimicrobial peptides. The discovery may help understand the unique mechanism of action of a-MSH peptides and unlock new treatments for fungal infections.
Researchers have found that delta opioid peptide may help protect brain cells from the ravages of Parkinson's disease by inducing a state of suspended animation. The compound was shown to reduce brain damage and neurological deficits in animal models of stroke, suggesting potential benefits for patients.
Researchers at the University of Illinois have created synthetic cytochromes by designing a small cyclic peptide that binds to iron millions of times more strongly than without it. This peptide's unique structure enables it to facilitate electron transport across cell membranes, potentially leading to effective antibiotics.
The study identifies five insulin-like peptides that regulate mosquito life cycle and disease transmission, providing new targets for genetic interference. The discovery could lead to the development of more effective control methods against malaria.
Scientists study emesis in genetically engineered mice lacking specific PDE4 subtypes and infer that inhibition of PDE4D mediates nausea. The discovery could lead to the development of selective PDE4 inhibitors with anti-inflammatory effects, reducing side effects in humans.
Researchers have identified a protein fragment in cereal grains that causes celiac sprue, an autoimmune disorder requiring strict gluten-free diets. A bacterial enzyme that breaks down this peptide may also offer relief to those with the condition, according to a study published in Science.
Researchers at Ohio State University have developed a peptide treatment that inhibits experimental autoimmune encephalomyelitis (EAE) and suppresses the onset of multiple sclerosis-like symptoms. The treatment targets T cells by binding to CD80, preventing their activation and expansion in disease.
A new MIT technique involves growing cartilage cells within a novel gel, which is then delivered to damaged joints. The engineered tissue has mechanical and biochemical properties similar to native cartilage.
A new method to prevent HIV from infecting healthy cells has been discovered by a team of researchers at the University of Illinois. The study found that reverse-chirality D-peptides can block the virus's entry into cells, providing a potential new therapeutic option.
Researchers create custom-built antimicrobial agents using polymers and oligomers inspired by natural defense peptides. The new approach focuses on overall shape rather than specific chemistry, offering a novel solution for combating bacterial infections.
New drug targets have been identified by Buck Institute researcher Vivian Hook, Ph.D., that could help treat Alzheimer's Disease. The targets participate in producing the toxic beta-amyloid peptide, which accumulates to form plaques in the brain.
Researchers have synthesized peptide mimics that may inhibit Pin1's action, which regulates cell division. The goal is to develop new anticancer therapies by targeting the cell-cycle-regulating enzyme Pin1.
A team of UB researchers has discovered a novel peptide in human saliva with potent antimicrobial activity against various types of bacteria and fungi, including drug-resistant strains. The peptide, labeled MUC7 20-mer, shows activity at very low concentrations and little toxicity to mammalian cells.
Researchers have found a new, hidden piece of the influenza virus that may kill immune system cells. This protein was discovered by accident while studying
Researchers have developed optimized antiviral peptide vaccines that exhibit enhanced efficacy against various viral infections, including HIV and SARS-CoV-2. These improvements are attributed to the incorporation of specific amino acid sequences that enhance immune responses.
A phase II study found that DiaPep277 treatment maintained insulin production in patients with early type 1 diabetes. The treatment also reduced the need for insulin therapy and altered immune response patterns.
A bacterial peptide has been identified as a key regulator of host responses to infection. This discovery opens up new avenues for the development of therapies targeting this process.
A secreted mitochondrial peptide regulates vascular tone by acting on the endothelial nitric oxide synthase, leading to increased NO production and vasodilation. This peptide also modulates the activity of other key enzymes involved in vascular relaxation.
Dr. Brian L Bray's innovative approach enables mass production of T-20, a 36-amino acid peptide blocking HIV entry. The process opens up new possibilities for peptides as therapeutics and may treat millions of Americans with HIV.
A new DNA-based cancer treatment has shown promise by targeting and eliminating tumor cells. Researchers have discovered that DNA vaccination can place tumors in a state of immune activation, making them more susceptible to attack.
Researchers develop a technique to conjugate peptides to virus-like particles, generating high-titer antibodies that inhibit disease-causing cytokines. This approach shows promise in blocking or delaying onset of autoimmune diseases such as arthritis.
Researchers at Scripps Research Institute develop cyclic peptide nanotubes that disrupt bacterial cell walls, killing deadly pathogens. These 'nanotube' stacks have strong bactericidal activity and may minimize resistance development.
Researchers analyze kinetics of amyloid b1-40 peptide clearance in mice brains, finding vascular transport is primary mechanism. They also suggest ApoE plays role in amyloid clearance pathway.
Jan Lohmann and Thomas Bosch report a discovery of the novel peptide HEADY, which acts as a potent inducer of head formation in lower metazoans. Grafting experiments show that HEADY induces a secondary head in Hydra tissue, revealing its role as a developmental switch for axis specification.
A study published by Emory University researchers found that a naturally occurring neurotransmitter called CART peptide produces behaviors associated with cocaine and methamphetamine. The finding suggests a role for the brain chemical in modulating or mediating the actions of drugs and potentially treating addiction.
Researchers have identified a sequence of amino acids found in fibronectin that accelerates healing of hard-to-treat skin wounds in obese, diabetic mice. The substance completely healed skin puncture wounds in eight days, compared to 20-42 days in untreated diabetic mice.
Researchers discovered a direct link between apoE and cerebral amyloid angiopathy (CAA), a leading cause of bleeding strokes in the elderly. Decreasing apoE expression may inhibit CAA buildup, lowering the risk for cerebral hemorrhage.
Researchers identify a component of Chilean tarantula venom that specifically blocks stretch-activated channels, implicated in various physiological processes. This peptide toxin shows promise in treating conditions such as congestive heart failure, heart attacks, and brain tumors.
The journal features novel approaches to analyzing complex peptides, such as pramlintide, and developing injectable implants for sustained drug release. Liposomes are also explored as carriers for antimicrobial peptides like Leucinostatin A.
Researchers developed a non-toxic peptide that prevents metastatic prostate cancer from spreading to other organs in laboratory rats. The peptide, PHSRN, was effective even when primary tumors were allowed to grow before treatment began.
Researchers discover a method to find peptides that mimic antibodies by binding to specific peptide epitopes, opening up new possibilities for biomedical research and medical diagnostics. The discovery could lead to more field-practical sensors to detect biowarfare agents and other applications.
Scientists found that pituitary adenylyl cyclase-activating peptide (PACAP) works in concert with glutamate to adjust the body's internal clock. Bright light at night triggers the release of both molecules, which convey information about light properties to the brain.
Researchers at the University of Illinois have isolated and characterized an insulin gene from the marine mollusk Aplysia californica. The study reveals a unique peptide, the 'D' peptide, which is separated from the standard two-chain insulin structure by a 'C' peptide.
Researchers have developed a new family of chemicals that bind specifically to the gp41 pocket, halting HIV's ability to infect cells. The compounds, created using mirror-image phage display, show promise as potential oral treatments for HIV, with advantages including reduced cell membrane penetration and lower likelihood of resistance.
Scientists used peptide injections to divert the immune system and prevent disease progression in mice with type-I diabetes. The study suggests peptide-based immunotherapy may be effective for people at risk of developing the autoimmune disease.
Researchers found that a small peptide, IM862, showed significant anti-angiogenesis activity in a human clinical trial, resulting in major responses in 37% of patients. The peptide inhibits blood vessel formation and modulates the immune system, offering a potential treatment for Kaposi's Sarcoma with improved safety profiles.
Northwestern University researchers have identified key peptides that can halt and even reverse kidney disease in lupus. The peptides were found to be effective in delaying the onset of severe kidney disease in young mice and prolonging survival in adult mice with established kidney disease.
Researchers discover the structure of a key compound enabling the bacterium's deadly mechanism and create molecules that block its effects in mice. The study provides a novel way to combat Staphylococcus aureus infections without killing the bacteria, potentially addressing antibiotic resistance.
A Purdue University study shows that proteins can replicate themselves and adapt to changes, expanding the scientific view of how life began. The study also found that changes to the environment affect the types of peptides that can be formed.
Scientists have identified peptides substance P and neurokinin A as key components in the body's pain responses. The study suggests that these peptides work together to produce moderate-to-severe pain, offering a potential target for new pain treatments.
Researchers have developed molecular sensors that can detect specific proteins in blood plasma or other biological fluids with high accuracy. The sensors could also be used to construct an environmental detector, giving new insights into cell functioning and promoting medical diagnostics.
Researchers discovered a molecule, ERAB, that causes early neuron damage in Alzheimer's disease. The finding may lead to therapies that inhibit the interaction of ERAB and amyloid-B peptide, protecting neurons from damage.
Researchers at Johns Hopkins Medicine discovered a peptide that closes an NMDA glutamate receptor, potentially aiding the development of stroke treatment drugs. The peptide, known as Mag-1.5, can help regulate communication between nerve cells and may provide insights for potential new therapies.