Articles tagged with Reverse Transcriptase
Researchers identified novel truncated RNAs from jumping genes that encode reverse transcriptases in the aging human brain, particularly in neurons. This discovery may provide new insights into Alzheimer's disease and potential therapeutic targets.
Researchers elucidated the spatial structure and molecular mechanisms of 'prime editor,' a novel gene-editing tool that achieves reverse transcription without DNA cutting. This breakthrough contributes to designing gene-editing tools accurate enough for gene therapy treatments, opening new avenues for both basic and applied research.
Researchers from Brigham and Women's Hospital found that anti-HIV drugs can prevent liver abscess formation during Escherichia coli infections by blocking reverse transcription. This mechanism could lead to a new way of treating and preventing deleterious consequences following bloodstream infections.
Scientists have created a new generation of prime editors based on the Cas12a protein and circular RNAs, expanding the scope of precision genome editing. The new editors show high editing efficiencies and low off-target effects, paving the way for diverse applications in biological research, disease treatment, and crop breeding.
A clinical trial reveals that lamivudine, a widely used HIV treatment, halted disease progression in 28% of patients with fourth-line metastatic colorectal cancer. The study suggests an unexpected promising direction for cancer treatment and encourages the exploration of pairing reverse transcriptase inhibitor therapy with immunotherapy.
Researchers from the University of Birmingham have confirmed a novel COVID-19 testing method called RTF-EXPAR that is highly sensitive and fast, giving results in under 10 minutes even at low viral levels. The test was shown to be equivalent to PCR and LAMP tests but faster.
Thomas Jefferson University researchers identified a highly efficient human reverse transcriptase, polymerase theta, which can convert RNA sequences back into DNA. This finding challenges the long-held assumption that polymerases only work in one direction and has implications for various fields of biology.
Researchers have developed a method to quantify transfer RNAs (tRNAs) in cells, which can reveal insights into tRNA regulation in health and disease. The mim-tRNAseq approach accurately measures tRNA abundance and modification status, enabling the study of tRNA dynamics in different tissues and during development.
Researchers have gained a deeper understanding of telomerase, an enzyme that maintains DNA in telomeres. Telomerase is active in cancer cells, enabling them to grow and spread. The study provides clues about how to target the enzyme's activity to develop new drugs.
A study published in Science reports that HIV/AIDS drugs, such as NRTIs, can prevent retinal degeneration in a mouse model of dry AMD by blocking the innate immune pathway called inflammasome. This discovery offers hope for repurposing these inexpensive and safe drugs to treat untreatable conditions.
Researchers at the University of Pittsburgh School of Medicine have discovered a unique mechanism of drug resistance in HIV-1 reverse transcriptase. The discovery provides new insights into how therapy-induced point mutations confer drug resistance and may lead to the design of new NNRTI drugs.
Researchers discovered that manganese can significantly lower HIV's reverse transcriptase enzyme activity. By targeting the manganese transporter, scientists may develop a new class of anti-retroviral drugs to stop HIV replication.