Articles tagged with Apoptotic Cells
Researchers explore the role of efferocytosis in reducing inflammation and containing injury spread after an ischemic stroke. Efferocytosis may offer a promising therapeutic strategy to promote neural regeneration and minimize brain damage.
Researchers found that apoptotic cells induce apoptosis in neighboring hair follicle cells during the regression cycle. The study proposes a mathematical model of the hair follicle regression cycle, which suggests that the dermal papilla plays an essential role in initiating apoptosis.
A team of Chinese and UK researchers has identified superoxide dismutase 1 (SOD1) as a potential target for reversing drug resistance in ovarian cancer. By using nanoparticles to deliver siRNA that reduces SOD1 levels, the study showed reduced growth and decreased resistance to cisplatin in female mice.
Researchers found that combining BCL-2 inhibitors can selectively eliminate senescent cells, improving efficacy and reducing toxicity by targeting high-MCL-1 expressing subpopulation of cells. This synergistic approach enables lower doses of drugs to be used, overcoming resistance to monotherapy.
Researchers at Nagoya University have identified a signaling cascade involved in the regeneration of damaged nerves in roundworms, which shares similarities with the recognition and engulfment of apoptotic cells. This discovery may lead to pharmaceutical interventions to treat conditions like brain and spinal cord injuries.
Researchers discovered two distinct mechanisms of cell extrusion from epithelial sheets, with low-density cell crawling and lamellipodia extension being the predominant mechanism at low cell density, while purse-string contraction takes over at high densities.
Researchers found that maslinic acid induces extrinsic cellular death pathway in Caco-2 cells without protein p53, leading to early apoptosis. The study suggests natural antitumoral agents with dual apoptotic pathways could be effective in treating colon cancer.
Recent studies demonstrate that ethanol directly induces apoptotic cell death of neurons, leading to brain damage and cognitive deficits. The researchers found that ethanol activates the p53-related cell cycle arrest pathway, resulting in neuronal apoptosis.
Researchers developed a small molecule receptor that can detect a lipid molecule revealing cellular death, particularly in cancer cells targeted by anti-cancer drugs. The discovery could enable oncologists to determine the effectiveness of anti-cancer drugs in days rather than weeks.
A study by Dini et al. investigates the effect of 6 mT Static Magnetic Field (SMF) on phagocytosis in human macrophages, finding that it depends on the degree of macrophage differentiation. The results suggest that moderate intensity SMF can modify cell surface morphology and influence fluid-phase endocytosis and phagocytosis.
Research by B.L. McVicker et al. found that reactive oxygen species are involved in ethanol-mediated cell death, but their presence is not solely responsible for apoptosis. The study also revealed that sustained cellular glutathione levels play a crucial role in this process.
Scientists have identified a new cancer therapy that sensitizes human cancer cells to a promising treatment, combining tumor necrosis factor death receptor ligand with multikinase inhibitor sorafenib. The combination enhances the potency and effectiveness of this treatment, overcoming resistance in some cancer cells.
Researchers at UCSD School of Medicine discovered that C-reactive protein (CRP) binds to oxidized LDL, suggesting a potential trigger for the development of atherosclerosis. The study highlights CRP's role in recognizing phosphocholine on oxidized LDL and apoptotic cells.