Researchers at Thomas Jefferson University have identified a new cell type, the dermal dendrocyte, that increases in number in tumors of early human Kaposi's sarcoma. The discovery offers a potential tool for studying the disease and its connection to abnormal wound healing and other conditions.
Rutgers University has been awarded millions by the NIH for its genetic research efforts, expanding its capabilities to study disease genetics globally. The new funding will support researchers in studying common pools of subjects to identify genes predisposing individuals to diseases.
Scientists discovered that a protein called ATR protects fragile sites from breaking during DNA replication, controlling genome stability. Fragile site breaks are common in tumor cells and near genes associated with tumors, suggesting defects in the ATR pathway may contribute to cancer progression.
Researchers found imatinib inhibited tumor growth and cell proliferation in mice with human Ewing's sarcoma tumors, offering a potential new therapy for the disease. Higher concentrations of imatinib were needed to kill Ewing's sarcoma cells than other tumor cells.