Articles tagged with Cell Metabolism
A natural milk ingredient called nicotinamide riboside has been found to protect against obesity in mice. It works by boosting levels of NAD+, a molecular sidekick for SIRT1, which helps with metabolism and longevity.
Researchers have found that insulin directly affects the brain's reward circuitry, leading to increased food intake and obesity in mice. This study suggests that insulin resistance may contribute to the difficulty in managing weight loss. Further research is needed to understand the clinical implications of these findings.
Researchers identified a natural compound in apple peels as a promising new treatment for muscle wasting. Ursolic acid enhanced insulin signaling and corrected gene signatures linked to atrophy, promoting muscle growth and reducing blood levels of glucose and cholesterol.
A recent study found that long-term dietary consumption of capsaicin in chili peppers can reduce blood pressure in genetically hypertensive rats by activating the TRPV1 channel and increasing nitric oxide production. This could lead to potential benefits for humans with high blood pressure.
A study published in Cell Metabolism identifies GPIHBP1 as the key protein responsible for transporting lipoprotein lipase (LPL) into capillaries. This discovery offers new insights into the causes of hypertriglyceridemia, a risk factor for cardiovascular disease.
A study reveals that dynamic changes in DNA, known as epigenetic marks, play a crucial role in the development of diabetes. Researchers found that these changes occur rapidly and can be influenced by environmental factors such as diet and physical activity.
A study published in Cell Metabolism identifies 20 genes that regulate cellular cholesterol levels, potentially pointing to new risk factors for cardiovascular disease. These findings may also pave the way for new cholesterol-lowering drugs.
A new study reveals that high-fat diets supplemented with extra branched chain amino acids can lead to insulin resistance and diabetes in rats. The researchers found that BCAA tend to climb along with insulin resistance, and its effects are exacerbated when combined with high fat consumption.
A gene variant that protects against weight gain and insulin resistance becomes a bad actor on high-fat diets, new research suggests. Mice with the Ala12 variant show improved insulin sensitivity and better plasma lipid profiles on balanced diets but worsen these outcomes when fed a diet high in fat.
Researchers found that transplanted subcutaneous fat into mice visceral cavity showed improved blood sugar and insulin levels, while visceral fat had detrimental effects. The findings suggest fat cells in different depots have intrinsically different properties.
Researchers identified a region on HIP1 that could bind HIPPI, potentially leading to the degeneration of nerve cells. By targeting this interaction, they hope to design a drug that can prevent the disease.
Researchers have identified a new 'starvation hormone' that plays a critical role in the metabolic shift seen in animals on low-carb, high-fat diets. Increased levels of liver-derived FGF21 hormone are required for mice to switch gears and begin burning fat.
Researchers found that increasing protein in the diet augments the body's PYY hormone, reducing hunger and aiding weight loss. High-protein diets stimulate greater release of PYY than high-fat or high-carbohydrate meals.