Articles tagged with Cell Metabolism
A study published in Cell Metabolism identifies 20 genes that regulate cellular cholesterol levels, potentially pointing to new risk factors for cardiovascular disease. These findings may also pave the way for new cholesterol-lowering drugs.
A new study reveals that high-fat diets supplemented with extra branched chain amino acids can lead to insulin resistance and diabetes in rats. The researchers found that BCAA tend to climb along with insulin resistance, and its effects are exacerbated when combined with high fat consumption.
A gene variant that protects against weight gain and insulin resistance becomes a bad actor on high-fat diets, new research suggests. Mice with the Ala12 variant show improved insulin sensitivity and better plasma lipid profiles on balanced diets but worsen these outcomes when fed a diet high in fat.
Researchers found that transplanted subcutaneous fat into mice visceral cavity showed improved blood sugar and insulin levels, while visceral fat had detrimental effects. The findings suggest fat cells in different depots have intrinsically different properties.
Researchers identified a region on HIP1 that could bind HIPPI, potentially leading to the degeneration of nerve cells. By targeting this interaction, they hope to design a drug that can prevent the disease.
Researchers have identified a new 'starvation hormone' that plays a critical role in the metabolic shift seen in animals on low-carb, high-fat diets. Increased levels of liver-derived FGF21 hormone are required for mice to switch gears and begin burning fat.
Researchers found that increasing protein in the diet augments the body's PYY hormone, reducing hunger and aiding weight loss. High-protein diets stimulate greater release of PYY than high-fat or high-carbohydrate meals.