Articles tagged with Cell Metabolism
Researchers at UConn Health have discovered that eliminating senescent cells in human fat tissue can alleviate signs of diabetes and improve insulin sensitivity. The study suggests that clearing away these dysfunctional cells could lead to game-changing new treatments for Type 2 diabetes.
Researchers found that excess carbohydrates can lead to metabolic distress by blocking the synthesis of important antioxidants and increasing insulin levels. This study provides new insights into the relationship between carbohydrate overfeeding and metabolic health.
Researchers at Osaka University found that E-NTPD8 regulates luminal ATP levels, which affects immune cells and promotes inflammation in colitis. Depletion of neutrophils improved symptoms, highlighting the enzyme's role in preventing severe colitis.
A recent study published in Cell Metabolism found that reducing naturally occurring errors in protein synthesis improves both health and lifespan. By engineering a mutation in ribosomes, researchers observed fewer protein mistakes and improved heat resistance, leading to longer lifespans in yeast, worms, and fruit flies.
Scientists investigate rhythmic changes in yeast cells' hydrogen peroxide levels and find that inactivating peroxiredoxin decouples cell division from metabolism. This discovery could provide insights into uncontrolled cell division in tumor cells.
Sarah-Maria Fendt and Markus Ralser receive the EMBO Gold Medal for their pioneering work in understanding metabolic changes during cancer proliferation and metastasis formation. Their discoveries have the potential to develop more effective cancer therapies.
Researchers found gold nanoparticles undergo significant transformations after a few weeks in cellular environments. They revealed mechanisms of detoxification and cell protection, also seen in the degradation of other nanomaterials.
A team of researchers from the University of Birmingham has found a potential new target to treat inflammatory disease. They discovered that lactate build-up in inflamed tissue exacerbates the inflammatory response, and molecules involved in transporting sodium lactate could be a target for treatment.
A randomized, controlled trial found that ultra-processed diets led to higher calorie consumption and weight gain compared to unprocessed diets. Participants consumed an average of 508 calories more per day on the ultra-processed diet, resulting in a two-pound weight gain.
A small-scale trial found that participants eating ultra-processed foods consumed more calories and gained weight than those on a minimally processed diet, despite similar calorie counts. The study suggests that ultra-processed foods may be a significant contributor to overeating and weight gain.
A study using PET technology found that dopamine release in the brain happens twice during a meal: first when eating and second when food reaches the stomach. This release is linked to brain regions involved in reward, sensory perception, and higher cognitive functions.
The study found that dietary cholesterol alters cellular programming, promoting hormone-producing cells and nutrient-handling cells. Low nutrient availability triggers changes in intestinal structure and metabolism with long-term effects on metabolic health.
A new study published in Cell Metabolism found that limiting the times when lab mice eat can correct obesity and other metabolic problems, even when they're fed an unhealthy diet. The results suggest a previously unknown link between disruption of the clock and eating behavior.
Research finds that inefficient breakdown of fats in fat cells predicts later weight gain and metabolic complications such as type 2 diabetes. An algorithm based on clinical and blood measures can detect impairments in hormone-stimulated lipolysis, identifying women at high risk of becoming overweight or obese.
A study published in Cell Metabolism reveals that mitochondrial protein production regulates the well-being of cells via unknown communication links. As cells age, this communication collapses, leading to vital functions deteriorating or failing.
Researchers identified a lipid that circulates in the blood after exercise and exposure to cold, which may help reduce triglyceride levels and improve cardiovascular health. The lipid, called 12,13-diHOME, is produced by brown fat and promotes the uptake of fatty acids into working muscles during exercise.
A calorie restriction trial in healthy adults aged 21-50 found significant improvements in biomarkers of aging, including reduced oxidative stress and slowed metabolic rate. The study suggests that sustained calorie restriction may help decrease risk for chronic disease and prolong life.
Two independent mouse studies found that ketogenic diets improved memory in older animals and increased their chances of living longer. The diets also preserved physical fitness and altered insulin signaling pathways in the mice. Further research is needed to fully understand the effects of a ketogenic diet on human health and aging.
A recent mouse study at UC Davis School of Veterinary Medicine reveals that a high fat, ketogenic diet increases median life span by 13% and improves quality of health in later life. The study also shows improvements in memory and motor function, as well as prevention of age-related markers of inflammation.
A study published in Cell Metabolism found that high glycogen levels actually impair endurance muscle performance in mice. Glycogenin-deficient mice underperformed normal mice despite having higher glycogen levels, suggesting a switch from oxidative to glycolytic metabolism in slow-twitch muscles.
A recent study found that different people react differently to white and whole wheat bread, with half responding better to processed flour and the other half to sourdough. The researchers developed an algorithm to predict individual responses, pointing towards a new paradigm in nutrition based on personal microbiomes.
Researchers discovered that two-liquid cocktails exhibit long-range correlations at equilibrium and when disturbed, resulting in coexistence of different characteristics within the same fluid. Understanding these effects is crucial for studying diffusion mechanisms in various physical and biological processes.
A study published in Cell Metabolism found that varying oxygen levels can reset the circadian clock of mice, which could inform how airlines moderate cabin air pressure. The research also suggests potential benefits for humans, including alleviating jetlag and improving air travel comfort.
Biomedical researchers need to replicate results in multiple animal models and report negative data to ensure reproducibility. Experts propose strategies such as holding public discussions, developing accountability metrics, and improving methods reporting.
A growing number of scientists argue that sex hormones and other variables affect how therapeutics behave, necessitating male and female inclusion in trials. Hormonal fluctuations during the menstrual cycle can significantly impact research, making it essential to consider these differences when testing drugs or transplant tolerance.
Researchers found that polyamine supplementation reverses slowed circadian clocks in aging mice, opening new possibilities for nutritional interventions. The discovery has potential implications for age-related diseases such as cancer and Alzheimer's disease.
A new study suggests that fish oil diets are more effective than lard diets due to the presence of certain gut bacteria. Mice transplanted with gut microbes from a fish oil diet showed reduced weight gain and inflammation compared to those with lard diet microbes.
Researchers have found that human irisin circulates in the blood at nanogram levels and increases during exercise. The discovery resolves a long-standing controversy over irisin's existence, with alternative start codons explaining its production in skeletal muscle cells.
A study by Kevin Hall found that restricting dietary fat leads to greater body fat loss than carb restriction, even though a low-carb diet increases fat burning. The research used controlled feeding studies and measured participants' food intake over two 2-week periods.
A new study found that bariatric surgeries alter the gut microbiome in ways that last for at least a decade, leading to sustained weight loss and improved metabolic health. The changes are specific to the surgery and not just a reflection of weight loss alone.
Researchers developed a calorie-restricted diet that mimics fasting to promote regeneration and extend lifespan in mice. A human pilot study found similar benefits, with decreased risk factors for aging-related diseases.
A recent study published in Cell Metabolism has raised doubts about the age-reversal properties of GDF-11, a molecule previously linked to anti-aging effects. The research found that GDF-11 actually worsened muscle regeneration in older animals, contradicting previous findings.
Researchers investigated a potential link between new weight-loss drugs and increased colon cancer risk, driven by the intestinal growth factor properties of glucagon-like peptide-1 (GLP-1). The study suggests that patients with a previous history or increased risk of colon cancer may not be ideally suited for these therapies.
Two studies suggest that low protein intake may be beneficial for longevity until old age, while high-protein diets are associated with increased cancer risk and mortality. High-quality protein with low fat and complex carbohydrates is recommended for optimal health and long life.
The study reveals that UCP2 is involved in increased metabolism in embryonic stem cells and cancer cells, while UCP4 is associated with nerve cell metabolism. The findings suggest that UCP proteins can be used to detect diseases at an early stage, such as cancer and neurodegenerative illnesses.
Researchers discovered a molecule produced during exercise that helps protect against metabolic diseases, including diabetes and heart disease. The molecule, β-aminoisobutyric acid (BAIBA), was found to increase fat cells' ability to burn calories and balance blood sugar levels.
A recent study published in Cell Metabolism reveals that a single mutation in the SIRT1 gene can cause type 1 diabetes in humans. The researchers identified a previously undocumented mutation that led to an amino acid substitution in the SIRT1 protein, resulting in high levels of blood sugar.
Researchers created an atlas that maps molecular connections between caloric restriction and aging, identifying pathways in mitochondria that control metabolism. The study suggests therapies targeting Sirt3 function could provide novel interventions to prevent age-related illnesses.
A natural milk ingredient called nicotinamide riboside has been found to protect against obesity in mice. It works by boosting levels of NAD+, a molecular sidekick for SIRT1, which helps with metabolism and longevity.
Researchers identified a natural compound in apple peels as a promising new treatment for muscle wasting. Ursolic acid enhanced insulin signaling and corrected gene signatures linked to atrophy, promoting muscle growth and reducing blood levels of glucose and cholesterol.
Researchers have found that insulin directly affects the brain's reward circuitry, leading to increased food intake and obesity in mice. This study suggests that insulin resistance may contribute to the difficulty in managing weight loss. Further research is needed to understand the clinical implications of these findings.
A recent study found that long-term dietary consumption of capsaicin in chili peppers can reduce blood pressure in genetically hypertensive rats by activating the TRPV1 channel and increasing nitric oxide production. This could lead to potential benefits for humans with high blood pressure.
A study published in Cell Metabolism identifies GPIHBP1 as the key protein responsible for transporting lipoprotein lipase (LPL) into capillaries. This discovery offers new insights into the causes of hypertriglyceridemia, a risk factor for cardiovascular disease.
A study reveals that dynamic changes in DNA, known as epigenetic marks, play a crucial role in the development of diabetes. Researchers found that these changes occur rapidly and can be influenced by environmental factors such as diet and physical activity.
A study published in Cell Metabolism identifies 20 genes that regulate cellular cholesterol levels, potentially pointing to new risk factors for cardiovascular disease. These findings may also pave the way for new cholesterol-lowering drugs.
A new study reveals that high-fat diets supplemented with extra branched chain amino acids can lead to insulin resistance and diabetes in rats. The researchers found that BCAA tend to climb along with insulin resistance, and its effects are exacerbated when combined with high fat consumption.
A gene variant that protects against weight gain and insulin resistance becomes a bad actor on high-fat diets, new research suggests. Mice with the Ala12 variant show improved insulin sensitivity and better plasma lipid profiles on balanced diets but worsen these outcomes when fed a diet high in fat.
Researchers found that transplanted subcutaneous fat into mice visceral cavity showed improved blood sugar and insulin levels, while visceral fat had detrimental effects. The findings suggest fat cells in different depots have intrinsically different properties.
Researchers identified a region on HIP1 that could bind HIPPI, potentially leading to the degeneration of nerve cells. By targeting this interaction, they hope to design a drug that can prevent the disease.
Researchers have identified a new 'starvation hormone' that plays a critical role in the metabolic shift seen in animals on low-carb, high-fat diets. Increased levels of liver-derived FGF21 hormone are required for mice to switch gears and begin burning fat.
Researchers found that increasing protein in the diet augments the body's PYY hormone, reducing hunger and aiding weight loss. High-protein diets stimulate greater release of PYY than high-fat or high-carbohydrate meals.