Articles tagged with Fibroblasts
A new study by the University of Pittsburgh Medical Center has found that muscle-derived stem cell cultures can improve leak point pressure and regenerate deficient urethral muscle, even when contaminated with fibroblasts. The research paves the way for a more efficient and effective treatment for urinary incontinence.
A new study suggests that resveratrol in red wine can prevent the excessive production of collagen in heart cells, leading to a stiffening of the heart muscle and reduced blood pumping efficiency. Drinking moderate amounts of red wine may offer protective effects against hypertension and heart failure.
UC Riverside researchers found that cigarette smoke delays the formation of healing tissue and sets the stage for increased scarring. The study, led by Professor Manuela Martins-Green, used doses equivalent to 'first-hand' and 'second-hand' exposure in humans and mice, revealing the negative effects on fibroblasts' structure and function.
Researchers found that individual fibroblasts in rat and mouse tissues exhibit robust, persistent circadian rhythms of clock gene expression for at least 1-2 weeks in culture. This discovery confirms that peripheral tissue clocks are indeed independent and self-sustaining.
Researchers have identified a link between the fibroblast growth factor system and major depressive disorder, with those treated with SSRIs showing smaller changes. The study's findings offer new insights into the biological mechanisms underlying mood disorders and potential avenues for targeted therapeutics.
Researchers found that adding texture to implant surfaces increased compatibility with fibroblasts, reducing the risk of dead tissue build-up and infections. The study suggests that textured surfaces could lead to fewer implant replacements and improved patient outcomes.
Research finds that passive smoking hinders healing by changing the arrangement of fibroblast cells' cytoskeleton, making them less mobile and more prone to abnormal scarring. This can lead to slower wound closure rates in smokers compared to non-smokers.
A team of scientists at Vanderbilt University Medical Center discovered that tumors can develop in normal epithelial cells due to changes in signals from nearby fibroblasts. The study, published in Science, shows that eliminating a specific cell signaling pathway in fibroblasts leads to precancerous lesions and invasive cancers in mice.
Scientists found certain fibroblasts can transform into myofibroblasts, leading to fibrosis, and lipofibroblasts, developing into fat cells that cause thyroid eye disease. This research may lead to new diagnostic tools and treatments for diseases like fibrosis and fatty tissue buildup.
Researchers found that oxygen-sensitive genes in cardiac fibroblasts transform into myofibroblasts, critical for wound healing after a heart attack. The newly formed myofibroblasts help replace damaged tissue.
Syndecan-4 is essential for wound repair, as its knockout leads to marked defects in angiogenesis and tissue healing. In contrast, fibroblasts from syndecan-4-deficient mice display normal focal adhesion assembly and response to FGF-2.
Researchers identified a new role of fibroblasts in cancer development, showing that epithelial cells engage in a molecular dialogue with surrounding fibroblasts to progress towards cancer. This finding could lead to new diagnostic markers and therapeutic targets.