Articles tagged with Melanocytes
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A new study finds that human tyrosinase plays a central role in metabolizing hydroquinone into reactive intermediates causing dermal pigmentation. The research shows that these compounds accumulate differently depending on molecular size and bind to dermal proteins, forming ochronotic pigments.
A new study led by Northwestern University finds that tanning bed use increases melanoma risk by almost threefold, with DNA changes detected in areas protected from sun exposure. The study's findings support a broader field of DNA injury caused by tanning beds.
Researchers at Tokyo University of Science discovered a natural tyrosinase inhibitor from Corynebacterium tuberculostearicum that inhibits melanin synthesis and provides an alternative to toxic hydroquinone-based products. The compound, cyclo(L-Pro-L-Tyr), exhibits low toxicity and potential benefits for hyperpigmentation treatment.
Researchers found that melanocyte stem cells, responsible for hair color, lose their ability to mature and maintain hair color as people age due to getting stuck in the skin. The study showed that these 'stuck' cells cease regenerative behavior when they're no longer exposed to WNT signaling, leading to graying and loss of hair color.
Sensory neurons in human skin have been found to regulate melanocytes, influencing pigmentation and cell survival. The study identified a protein called RGMB as a key factor promoting melanocyte survival and darkness.
Researchers have identified stem cells in hair follicles that can regenerate the myelin sheath coating neurons, potentially treating nerve injuries and demyelinating diseases like multiple sclerosis. The study found that these cells can enhance functional recovery from neuronal injury.
Researchers at Harvard University have discovered that the 'blood stem cell niche' evolved to protect blood stem cells from ultraviolet (UV) rays in sunlight. This finding has significant implications for improving the safety of blood stem cell transplants, a procedure used to treat patients with blood diseases and cancers.
Researchers discovered a connection between genes controlling hair color and innate immune response in mice. Gray hair is associated with activation of the innate immune system, which produces signaling molecules to fight off viruses and bacteria.
Researchers have developed a method to create human-like skin pigmentation using 3D bioprinting, enabling standardized distribution of melanocytes and manipulation of pore sizes within the dermal regions.
Researchers at Tel Aviv University and Weizmann Institute successfully transformed mature cells from various parts of the body into melanocytes, responsible for producing skin pigment. This breakthrough enables the potential for curing deafness and developing novel transplants.
Researchers used AI to predict a trio of reagents that generated a never-before-seen cancer-like phenotype in tadpoles, demonstrating its potential in controlling complex biological systems. The study showcases how AI can help human researchers achieve new outcomes in fields like oncology and regenerative medicine.
Researchers identify Alx3 gene as key to African striped mouse's characteristic light-colored stripes. Analysis reveals similar stripe patterns in North American chipmunks, indicating independent evolution of trait.
Researchers discovered that melanocytes from light-skinned humans and albino mice secrete high levels of fibromodulin, which promotes angiogenesis. Fibromodulin's potential as a biomarker and therapeutic target for diseases with increased vascularization is discussed.
A study published in the Proceedings of the National Academy of Sciences found that human melanocytes rely on the TRPA1 ion channel to detect UVA light and trigger the production of melanin. This discovery strengthens the evidence of a parallel between the skin's response to UVA light and the eye's detection of light.
Researchers found that keratinocytes can control melanocyte pigmentation by producing chemical signals, leading to new possibilities for bioengineered skin grafts and cosmetics. This discovery has significant implications for individuals with medical conditions requiring skin transplants or pigment diseases.
A study published in The FASEB Journal has identified specific physiological properties that regulate melanocyte function, offering hope for new treatments of pigmentation disorders. Keratinocytes are found to influence pigment production and help regulate skin coloration.