Articles tagged with Mutant Cells
A robotic microscope system allowed researchers to track changes in individual neurons over time, revealing that formation of inclusion bodies prolongs neuron survival. Neurons with larger gene mutations had a higher cell death rate, but the overall death rate remained constant.
Scientists discovered how neurons communicate by removing a specific part of the calcium channel molecule, disrupting neurotransmitter release. The study, published in PNAS, sheds light on the fundamental process of neural communication, providing insight into cellular structure and function.
A study using Venn diagram tactics categorizes mutation types in cells from different patients, identifying a novel cause of lethal neonatal mitochondrial complex I deficiency. The authors demonstrate the technique's strength by pinpointing mutations in the NDUFS6 gene, a previously unknown contributor to this disease.
Researchers engineered mutations to 700 yeast genes and used computerized analysis to predict gene functions. The developed yeast strains are now commercially available for other researchers.
Mitochondria are targeted by a mutant protein called SOD1, leading to the progressive degeneration of motor nerve cells in spinal cord. The study provides the first explanation for how this mutant protein causes ALS, a disease characterized by wasted muscles and premature death.
A team of scientists found that a single genetic mutation in the BBS4 protein can cause complex disorders like obesity, diabetes, and retinal degeneration. The researchers discovered that the mutation affects microtubule function, which is essential for cellular division and cell death.
Dr. Bissell's research reveals that the cellular microenvironment plays a crucial role in gene expression and cell behavior. She discovered that malignant cells can be reverted to a normal phenotype through manipulation of the extracellular matrix.
Scientists discovered that specific DNA damages cause transcriptional mutagenesis (TM) in non-dividing cells, leading to mutant protein creation. TM can contribute to neurodegenerative diseases, cancer, and aging by causing faulty proteins to be produced during normal cellular processes.
Researchers discovered that neighboring non-neuronal cells can protect or rescue motor neurons from degeneration when they carry an ALS mutation. This finding suggests the potential of stem cell replacement therapy targeting non-neuronal cells to treat ALS. The study used mouse models with a mutation in the gene superoxide dismutase (S...
Researchers discovered that healthy astrocytes and glia can rescue motor neurons containing ALS-causing mutations from degeneration. The study suggests inserting healthy astrocytes into ALS patients may reduce or prevent motor-neuron degeneration.
A study found that acrylamide triggers mutagenesis by damaging DNA in mammalian cells. Low concentrations of acrylamide increased mutations in a transgene, similar to those caused by the known carcinogen BPDE.
A team of researchers discovered a protein that controls animal cell fusion, which is crucial for proper development and tissue formation. The study found that mutations in this gene lead to birth defects and organ malformations, highlighting the importance of understanding the fusion mechanism.
A recent study by Columbia researchers suggests that low doses of radiation can cause widespread mutations in living cells, even if they only affect a small percentage of the population. The findings highlight the importance of considering the 'bystander effect' when assessing radiation exposure risk.
A study published in JCI Journals reveals that an excess of healthy cells may hold leukemia in check. The researchers found that these healthy cells could be used as a therapeutic target to develop new treatments for the disease.