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Two novel pancreatic cancer cell lines with highly metastatic activity were established and analyzed

Researchers established two human pancreatic cancer cell sublines with high metastasis potential, MIA PaCa-2 In8 and Panc-1 In8, which demonstrated increased migration, invasion, and clonogenic abilities compared to their parental cells. The study also identified a dysregulated lncRNA-miRNA-mRNA competitive endogenous RNAs (ceRNAs) net...

SourceScience China Press·JournalScience China Life Sciences·DateMar 27, 2019

Some neurons choose mom's gene and others choose dad's

Research reveals that individual neurons or specific types of neurons can silence genes from one parent or the other, particularly during brain development. As the brain matures, these differences tend to decrease, but some genes continue to exhibit differential expression in adult brains.

SourceCell Press·JournalNeuron·DateFeb 23, 2017

Genomic imprinting gets complicated in adults

A recent study found that genomic imprinting, a process silencing one set of parental genes, can be regulated in adult tissues. The researchers observed variation in epigenetic marks between cell types, indicating a need for fine-tuned gene expression in different tissues throughout development and adulthood.

SourceCell Press·JournalCell Reports·DateOct 3, 2016

MSU discovers a new kind of stem cell

Researchers at Michigan State University have discovered a new type of induced Xen (iXEN) stem cells that can be created by reprogramming mature adult cells. These cells have unique properties and can shed light on reproductive diseases, potentially leading to advances in regenerative medicine.

SourceMichigan State University·JournalStem Cell Reports·DateMar 3, 2016

Protein changes are discovered that control whether a gene functions

A Penn State-led research team found that histone protein changes can control whether a gene functions, with the potential to maintain genetic expression and prevent disease. The study's findings have significant implications for the study of diseases like cancer and understanding cellular behavior.

SourcePenn State·JournalProceedings of the National Academy of Sciences·DateAug 6, 2013