Articles tagged with Sertoli Cells
Recent studies show chlorpyrifos exposure impairs spermatogenesis by compromising blood-testis barrier integrity, disrupting Sertoli cell junctional function and inducing ferroptosis. Chlorpyrifos primarily metabolite TCP triggers clockophagy-mediated ferroptosis in Sertoli cells.
Researchers developed tiny human ovary organoids using stem cells to understand gonad development and disease. The models replicate key aspects of ovarian follicles, offering a powerful platform for studying gene function in a controlled environment.
A team of researchers has identified a key gene responsible for ovarian development in mice, shedding light on the early stages of sex determination. The -KTS variant of WT1 is essential for female gonad formation, regardless of XX or XY chromosomes, and may hold clues to understanding disorders of sex development.
The study reveals that the Cdc42 gene is essential for proper alignment and function of Sertoli cells, which support sperm cell development. Disruptions in this gene can lead to reduced testicular function and infertility. Researchers hope to develop non-invasive diagnostic tests to identify specific causes of male infertility.
A study found that early weight loss in obese boys can improve reproductive function and reverse alterations in Leydig cell function, which could help prevent future fertility problems. The research suggests that managing childhood obesity may be necessary to prevent reproductive issues and lower the risk of other diseases.
Researchers from Osaka University found a link between excessive autophagy and reduced sperm production, suggesting a potential mechanism for male infertility. The study suggests that Rubicon regulates autophagic degradation of GATA4, promoting Sertoli cell function.
Michigan Medicine researchers created the most complete catalog of cells in the male gonads by analyzing over 30,000 individual cells from mouse testes. The study reveals a continuous sperm cell developmental program and identifies new cell types and molecular features that can help understand the causes of male infertility.
Researchers found that developing sperm cells lacking p73 detached prematurely and died, while Sertoli cells lost their characteristic morphology. The study demonstrates the critical role of p73 in regulating cell adhesions for male fertility.
Researchers successfully reprogrammed skin cells into germ cell-supporting embryonic Sertoli-like cells, which exhibit characteristics of native Sertoli cells. The trans-differentiated cells supported other cells in a Petri dish and had enhanced supportive capacity after transplantation into the brain.
Researchers have found that human Sertoli cells can proliferate in vitro and retain their functionality, making them suitable for therapeutic applications. The cells have also been successfully used as delivery systems for therapeutics in the deep lung areas, potentially providing an effective treatment alternative.
Researchers discovered that lower SMAD3 levels result in faster maturation, while absent levels lead to abnormal responses to testosterone. This finding has implications for altered pubertal timing, affecting adult height and bone density.
Saneron CCEL, a biotechnology R&D startup, has been awarded a $150,000 grant from the NIH to develop Sertoli cells combined with stem cells for treating spinal cord injuries. The company aims to provide readily available, non-controversial stem cells for cellular therapies.
Researchers have successfully restored sperm production in infertile mice by transplanting healthy Sertoli cells. The technique, developed by Dr. Ralph L. Brinster, may provide a new way to replace defective Sertoli cells and initiate normal spermatogenesis.
A new study demonstrates that pig cells can be transplanted into children with type 1 diabetes without the need for immunosuppressive drugs, resulting in some patients being off insulin. The use of embryonic stem cells and novel preservation methods also holds promise for increasing the availability of viable cells for transplantation.