Articles tagged with Target Cells
A team of researchers has identified a key mechanism in the degeneration of motor neurons in ALS, revealing that chaperone-mediated autophagy is significantly reduced in patients. This finding suggests that this cellular system may be a potential therapeutic target to slow disease progression.
Researchers have developed a novel approach to fight colorectal cancer using modified Listeria bacteria as a courier to deliver potent cancer-killing proteins into tumor cells. This method has shown significant anti-tumor activity and could potentially lead to the development of a safe and effective oral treatment.
A new study at Stellenbosch University found that blocking the enzymes involved in glycolysis could cut off the malaria parasite's primary energy source and kill it. This approach has shown promise for developing new malaria drugs, particularly against resistant parasites.
A novel lab-on-chip platform uses acoustofluidics to efficiently separate rare circulating tumor cells, enabling real-time diagnosis. The system's precision and energy efficiency hold promise for improved cancer diagnostics and personalized medicine.
Researchers developed AI-driven therapeutic platform mimicking viral structures to deliver therapeutic genes to target cells. The innovative approach achieved precise symmetrical structures and effectively delivered payloads, paving the way for breakthroughs in gene therapies and next-generation vaccines.
This study found that lowering the fecal immunochemical test positivity threshold can achieve comparable sensitivity and specificity to the multitarget stool RNA test without additional testing. The findings are similar to previous observations with multitarget stool DNA testing, suggesting a potentially simpler screening method.
Researchers have discovered that natural antimicrobial predatory bacteria, Bdellovibrio bacterivorous, produce fibre-like proteins on their surface to ensnare prey. This breakthrough enables scientists to use these predators to target and kill problematic bacteria in healthcare, food spoilage, and the environment.
Researchers at MMRI have developed a novel approach to minimize cardiac damage after a heart attack by targeting the spleen with histone deacetylase inhibitors. This targeting strategy results in a significant decrease in cardiac scar size and preservation of heart function, even after just one dose.
A randomized controlled trial suggests that a more liberal approach to red blood cell transfusions for heart attack patients with anemia may benefit outcomes without significant risk. The study found no statistically significant difference between two transfusion strategies, but results suggest a possible benefit of liberal transfusions.
Nucleic acid therapies aim to treat genetic disorders and diseases, but delivering therapeutics is a significant challenge. Researchers are investigating nanoparticle delivery systems to target specific cells and sub-cellular compartments for effective delivery.
Researchers have developed a way to load potent antibiotics like Polymyxin B into red blood cells, allowing them to selectively target and kill drug-resistant bacteria. This technology could help address the ongoing antibiotic resistance crisis and deliver drugs more quickly and directly to specific sites in the body.
A new CAR NK cell engineering approach requires two signals to eliminate target cells, improving tumor specificity and enhancing anti-tumor activity. This strategy mitigates NK cell exhaustion and fratricide, leading to better focus on and attack of only the tumor cells.
Researchers developed a mathematical model to predict the efficiency of nanoparticle delivery into cells, particularly in stem cells. They found that nanoparticles become trapped in bubble-like vesicles, preventing them from reaching their targets.
Researchers developed a MOF-based system for delivering DNA into target cells, overcoming challenges in gene therapy. The tiny structures protected genetic cargo and helped ferry it into the nucleus, where gene activity takes place.
A new study reveals that SARS-CoV-2 limits viral particle release and instead spreads through cell-to-cell transmission, enabling efficient infection without the need for antibodies. This stealthy transmission method makes it challenging for the host immune system to target and neutralize the virus.
Researchers have successfully developed an automatic suction device for Single-cell mass spectroscopy, enabling high efficiency and precision. The device uses cellular image analysis, confocal microscopy technology, and a software for one-click suction, achieving 22 samples per hour.
Scientists at Tufts University visualized the flu virus's dynamic surface protein structure that reaches out to hijack target cells, revealing a 'better mousetrap' mechanism. The discovery sheds new light on viral entry and may help develop more effective vaccines.
Researchers investigated the interaction between induced membrane vesicles and target cells, finding that proteinase K treatment inhibits internalization. The study suggests that artificial microvesicles can be designed to specifically deliver anti-tumor drugs to cancer cells.
A research team from SUTD developed a highly accurate single cell level sorting technology using sound waves, which enables the isolation of rare cell populations in complex biological samples. This technology has the potential to advance precision medicine for cancer treatment by examining DNA mutations at single cell level.
Scientists have created a detailed structural model of aerolysin, a bacterial toxin that causes gastroenteritis and sepsis. The high-resolution imaging reveals the toxin's mechanism of action, including its formation of a pore in target cells.
Researchers developed an integrated inertial microfluidic vortex sorter for simultaneous double sorting of rare target cells and removal of background cells. The device achieved highly purified target cell products, even in complex samples containing orders of magnitude larger number of background cells.
Researchers have deciphered the mechanism of interleukin 37 (IL-37), a powerful inhibitor of inflammation, revealing its ability to regulate and control inflammation by binding to specific receptors on target cells. The findings hold promise for developing new drugs to treat inflammatory diseases such as stroke, heart attack, and autoi...
Researchers at the University of Cambridge discovered that stem cells 'communicate' with damaged cells by transferring molecules via fluid-filled bags called vesicles, helping other cells modify the damaging immune response. This novel mechanism enables stem-cell-based therapies to work more efficiently.
A research team developed an adjuvant that optimizes lentivirus gene transfer by enhancing virus attachment to target cells, resulting in a three-fold increase in transduction rate. This improvement reduces the need for additional viruses, potentially leading to more effective treatments for genetic disorders.
A team of University of Pittsburgh engineers has designed artificial cells capable of self-organizing, performing tasks, and transporting cargo. The cells interact through nanoparticles and can be controlled to perform specific functions, offering a significant step towards synthetic cells that behave like natural organisms.
A team of scientists reveals that microRNAs (miRNAs) can be secretly packaged by cells and delivered to target cells, regulating their functions. This discovery expands our understanding of miRNA's role in mediating intercellular/interorgan communication.
Researchers at the Gladstone Institutes have discovered surfen, a small molecule that inhibits HIV's ability to bind to cells and enhance infection. The discovery could lead to new treatments for HIV, potentially reducing transmission rates through sexual contact.
Researchers at IRB Barcelona identified a new signaling mechanism in Drosophila melanogaster that allows two independent groups of cells to collaborate and send signals to target cells. This mechanism is crucial for proper cell function and development.
Researchers developed radioimmunotherapy to target and kill HIV-infected cells using antibodies. By injecting radioactive antibodies into mice with deficient immune systems, the treatment successfully reduced HIV-infected cell numbers and showed promise for eradicating the virus.
Fibroblast Growth Factors, such as Fgf8, play crucial roles in cellular decisions during development. Endocytosis regulates the spreading and effective signaling range of Fgf8 protein by controlling its internalization and degradation within cells. This process allows target cells to actively influence signal availability.