Articles tagged with Tumor Microenvironments
Researchers found that two different breast cancer models progressed at varying rates based on tumor microenvironment characteristics, with MMP9 playing a crucial role in promoting cancer growth. The study suggests that targeting MMP inhibitors may be more effective in specific patient populations.
Berkeley Lab scientists discovered that genetic makeup affects cancer risk from low-dose radiation, identifying key regions in the genome and tumor microenvironment. The findings could lead to genetic screening tests to identify people at high risk of cancer after exposure.
Hepatitis B virus (HBV) infection is associated with a complex tumor microenvironment in hepatocellular carcinoma (HCC), leading to carcinogenic progression. Targeted therapies targeting the microenvironment offer promise for treating this disease.
Researchers have identified a new therapeutic target for certain myeloproliferative diseases by targeting the microenvironment that sustains hematopoietic stem cells. The treatment involves using clinically approved medications to prevent or reverse damage to this microenvironment.
Researchers have developed a novel approach to treating CLL by disrupting the activity of the NF-kappaB pathway, which ensures survival and resistance of CLL cells. This approach may lead to re-sensitization of CLL cells to conventional chemotherapy and novel agents.
Researchers from Queen Mary University of London are using bioengineering techniques to grow the first complex 3-dimensional human tumour microenvironment in the laboratory. The goal is to understand how this 'tumour microenvironment' supports cancer growth and develop new treatments that target it.
Researchers at Thomas Jefferson University found that decorin, a naturally occurring substance, induces tumor suppressor genes in the surrounding tissue of triple negative breast cancer tumors. This breakthrough may lead to improved therapeutics for metastatic breast cancer.
Researchers found acidic pH microenvironments in tumors promote autophagy, allowing cancer cells to survive and proliferate. The study suggests a potential therapeutic strategy based on inhibiting autophagy, which could introduce novel treatment options for tumor progression.
Researchers found that transforming growth factor-β1 contributes to kidney disease by inducing fibrosis and nephron degeneration. Meanwhile, a new diagnostic criteria for T-cell lymphoma was discovered using mast cells and Th17 cells. Additionally, a novel peptide ASARM may implicate in impaired dentin mineralization in rickets.
Scientists have created unique microenvironment microarrays that reveal how adult stem and progenitor cells develop in a woman's breast. They found that the ultimate fate of these cells depends on signals from multiple microenvironments, suggesting a promising pathway for beneficial therapies.
A new computer simulation of tumor growth sets the stage for individualized cancer treatment. The model suggests that the microenvironment around tumor cells determines the tumor's ultimate cellular makeup and invasive potential.
Researchers at Einstein and U. Albany will create a microchip to detect metastatic cells in human tumors, enabling more aggressive cancer therapy. The project aims to improve understanding of tumor microenvironments and cancer spread.
Researchers at Northwestern University discovered that human embryonic stem cells can reprogram metastatic melanoma cells to a more normal state by mimicking their natural microenvironment. The findings suggest a new approach for investigating the effects of identifying key factors in reversing tumor cell properties.