Articles tagged with Regeneration
Researchers found that puerarin, a natural compound, activates growth-associated protein 43 in the spinal cord after sciatic nerve injury, contributing to neural regeneration. The study published in Neural Regeneration Research suggests a potential therapeutic role for puerarin in peripheral nerve injuries.
A study of 34 patients with persistent clinical symptoms and neurologic signs of impaired nerve function found that ultrasonography had a concordance rate of 98% with surgical results. The majority of patients (86%) showed good recovery after neurolysis, anastomosis, or transplantation.
Research highlights the importance of glial cells in CNS regeneration. Glial cells provide support and protection for neurons, but also influence the survival and fates of transplanted neural stem cells. Regulating their behavior can create a permissive microenvironment for neuronal regeneration.
Cerebral microbleeds have been shown to be a significant marker for diffuse axonal injury, which can lead to severe neurological disorders. The study highlights the importance of using susceptibility-weighted imaging to detect these tiny changes and evaluate traumatic cerebral microbleeds with high sensitivity.
Researchers found that Ginkgo biloba treatment improved recovery and reduced brain damage after inducing experimental stroke in mice. The treatment also enhanced neurogenesis due to increased protein expression of hemeoxygenase 1, an antioxidant gene involved in neurogenesis.
Researchers established a standardized model of radial nerve injury in rhesus monkeys to evaluate peripheral nerve repair. The study found that bone marrow stem cell-laden allografts achieved comparable nerve regeneration to autografts, suggesting potential for improved treatments.
Intravenous transplantation of BMSCs has been shown to promote nerve cell regeneration in injured cerebral cortex, supplementing lost nerve cells. This study provides evidence for the potential use of BMSCs as a therapeutic option for traumatic brain injury treatment.
Researchers at National Taiwan University have reviewed treatment options and imaging tools for peripheral nerve repair, contributing to knowledge in the field. The study proposes several imaging tools that may help visualize peripheral nerve regeneration in vivo and in real-time.
A recent study found that valproic acid significantly increased Bcl-2 and growth associated protein 43 expression, and reduced c-Jun expression after brachial plexus avulsion in Wistar rats. This suggests that valproic acid can protect neurons and enhance neuronal regeneration following the injury.
A recent study found that ursolic acid induces neural regeneration and repair after sciatic nerve injury in mouse models. The compound promoted the regeneration of injured nerve myelin sheaths and reconstructed muscular functions.
Researchers found that poly(lactic-co-glycolic acid) conduit transplantation can significantly enhance the quality of sciatic nerve regeneration compared to traditional autogenous nerve grafting methods. The conduits increased maximum tensile load, stress, and elastic limit load while reducing strain.
In a study published in Neural Regeneration Research, decimeter wave therapy was found to contribute to the regeneration and recovery of compressed nerves. Intraoperative electric stimulation also showed positive effects on nerve repair.
Researchers found that HEXIM1 blocks gene expression necessary for muscle regeneration after injury, leading to increased muscle mass and function in mice with reduced HEXIM1 levels. This suggests that HEXIM1 may be a key regulator of skeletal muscle regeneration and a potential therapeutic target for degenerative muscle diseases.
Researchers at Johns Hopkins Medicine have identified a protein called semaphorin 5A that prevents nerve growth after injury. By blocking its interaction with CSPGs, nerves can be freed to continue growing.
Acorda Therapeutics has received the L.W. Freeman Award for its pioneering work in regenerative therapies and functional improvements for spinal cord injury patients. The company's lead product, Fampridine-SR, is in Phase 3 clinical trials for chronic SCI and aims to restore function in people with SCI.
Damage to nerves caused by injury can lead to slow and poor recovery. However, a new study suggests that electrical stimulation can enhance nerve regeneration, allowing for faster healing in just two to three weeks. Researchers hope to test this method on people with nerve damage.
Researchers studying sea lamprey nerve regeneration found that fibers grow in the correct direction and create synapses with target cells, restoring function. The discovery led to hypotheses about a new mechanism of neurofilament transport pushing forward growth cones.