Articles tagged with Dna Demethylation
Researchers at UT MD Anderson Cancer Center have made significant advancements in targeted therapy treatments for advanced lung cancer and early-stage classical Hodgkin lymphoma. The studies showcase high response rates with novel combination therapies and a new understanding of how an enzyme affects infertility and cancer progression.
Researchers developed RF-SIRF, a quantitative method to detect and map reversed DNA replication forks with single-cell resolution. The study identified unique epigenetic codes for DNA replication stress that can be further examined to understand genomic stability, aging, and treatment response.
Recent discoveries have shed light on gene expression control in tumor growth, revealing the critical role of epigenetic marks and genomic imprinting. The findings have significant implications for cancer treatment, as they suggest that disrupting the tumor's access to neural signaling may halt its growth.
Researchers discover vitamin C promotes epidermal thickening by reactivating genes essential for skin cell growth, suggesting a promising treatment for thinning skin in older adults. Vitamin C supports active DNA demethylation by sustaining TET enzyme activity.
Cells employ a protein network to repress TE activity and keep themselves healthy. O-GlcNAc transferase (OGT) is a lead choreographer in this process, protecting cells from genomic instability by restraining TET activity.
A team of researchers from Xi'an Jiaotong-Liverpool University has engineered a short sequence of artificial DNA to target the mutant protein p53-R175H, linked to lung, colorectal, and breast cancers. The new molecule, dp53m, inhibits cancer cell growth and increases sensitivity to chemotherapy agent cisplatin.
Researchers at Osaka University found that Polβ prevents DNA breaks in brain cells of the hippocampus during early postnatal development, supporting cognitive development. The study also reveals a link between DNA demethylation and increased double-stranded breaks, which can lead to altered gene expression and impaired memory formation.
Researchers have identified a rice strain with improved nutritional profile by thickening its aleurone layer. The mutation of the OsROS1 gene responsible for this change offers a strategy to enhance nutritional value in rice and other cereal crops.
Scientists at the Institute of Molecular Biology have identified two proteins, Neil1 and Neil2, essential for DNA demethylation. These proteins boost the activity of Tdg, a central protein in DNA demethylation, promoting efficient removal of epigenetic marks.
Researchers at Johns Hopkins Medicine discovered that neurons use minor 'DNA surgeries' to toggle their activity levels, shedding light on brain disorders and learning. The study found a mechanism where Tet3 levels respond to synaptic activity, enabling neurons to maintain consistent levels of communication.
Chuan He has been selected as an HHMI investigator to uncover the mechanisms of reversible RNA methylation. His research team will use genomics tools and expertise in various biology fields to explore this new area.
Researchers found evidence of large-scale dynamic DNA demethylation in non-dividing brain cells, challenging scientific dogma. This discovery has major implications for understanding learning, memory, and mood regulation, as well as potential new treatments for depression and neurodegenerative disorders.