Articles tagged with Gene Flow
A study published in Developmental Cell identified several hundred genes involved in cell migration and material transport, shedding light on the mechanisms of human cancer spread. The research found that these genes share similarities with those found in human metastatic breast cancer cells.
Gene flow researchers found that separation distances between GM and conventional crops can meet most impurity thresholds, reducing the risk of genetic material transfer. The study also estimated that around 32,000 oil seed/B. rapa hybrids are produced in the UK every year.
Researchers used mathematical models to investigate transgene escape from confined crops, finding a high probability that leakage can occur sooner than expected. The study suggests that even with effective containment strategies, genes can still spread to wild populations within a relatively short time frame.
Researchers at the University of Wisconsin-Madison developed mathematical models to understand the effects of gene flow from crops to wild plants. The models show that crop genes can rapidly take over wild populations, leading to genetic changes, population decline and loss of natural traits.
Farm-raised male salmon outcompete wild males in spawning events, fertilizing large numbers of eggs with their rapid maturity and high reproductive performance. This accelerates the gene flow into native populations.
A University of Michigan study finds that ancient human fossils from Australia and Europe show distinctive characteristics to an older African population, contradicting the 'Eve theory'. The research suggests that multiple groups of humans survived and thrived globally, rather than a single ancestral group replacing others.
Researchers at NYU Langone Health discovered a link between a bladder gene and vesicoureteral reflux, a condition that causes urine to flow backward into the kidneys. The study suggests earlier detection and treatment of the condition could prevent kidney failure.
Researchers identified a protein in vertebrates that detects cell salt concentration and regulates its balance. The discovery may lead to improved treatment of kidney disorders and high blood pressure.
A recent NIH study discovered that gene alterations associated with cystic fibrosis may also contribute to chronic sinus problems in some individuals. The study found that nearly five times more patients with sinusitis carried CFTR alterations than those without the condition.
Researchers at Johns Hopkins have identified a previously unknown system that helps control the protein product made by the cystic fibrosis gene, called CFTR. The discovery could lead to improved drug testing and screening for cystic fibrosis therapies.
Researchers at Vanderbilt University Medical Center have identified Bone Morphogenic Protein Receptor Two (BMPR2) as the gene responsible for causing PPH, a fatal lung disease. The mutation of this gene causes cells to grow and clog blood vessels in the lungs, leading to high blood pressure.
Researchers have identified a protein that governs the flow of mineral-reducing pyrophosphate into joint tissues. This finding could provide powerful new insights into the basic mechanisms underlying some forms of arthritis, a group of diseases affecting half of people 65 and older.
Researchers at Dartmouth Medical School have clarified the molecular gears that drive biological clocks, revealing a simple model with striking parallels. The study found that light and dark cycles reset the clocks, but are not required to run them, and identified fundamental properties shared among all living clocks.
Researchers have successfully created genetically engineered mice that cannot produce their own vitamin C, a nutrient essential for growth and healthy tissues. These 'humanized' mice will aid in understanding vitamin C's role in diseases such as heart disease and cancer.
Researchers discovered that low nitric oxide levels in mouse newborns with hypoplastic lungs hinder the proper development of blood vessels, leading to persistent pulmonary hypertension and respiratory distress. The study aims to identify genes affecting lung development and function.
Researchers at Michigan Tech are transferring altered genes into fungi to facilitate nutrient flow through tree roots, helping trees grow faster and live healthier lives. The fungus provides a protective coating around the tree's roots, preventing insect pests and diseases from attacking.
Researchers have observed RNAP molecules possessing intrinsic transcription rates and propensities to pause and stop. The study provides new insights into how genetic expression in cells may be regulated, suggesting a kinetic competition between transcription and pausing.
Researchers discussed various molecular pathways that lead to cancer, including cellular senescence and oncogenic signaling. The symposium addressed the role of genetic instability and signaling pathways in cancer progression.
Researchers at UNC-CH have successfully repaired a genetic problem causing cystic fibrosis, offering new hope for patients. The technique involves correcting a mutation involving unnecessary information inside a gene, resulting in the production of normal messenger RNA.
Researchers found a gene, gata5, that can reprogram embryonic cells to become beating heart cells. The discovery suggests using this technique to cultivate and transplant genetically modified heart cells into people with failing hearts.
Researchers discovered a genetic cause of coronary artery spasm, a condition that causes chest pain or heart attack. The endothelial nitric oxide synthase (eNOS) gene mutation was prevalent in patients with the condition and also linked to increased risk in smokers.
A Purdue University researcher has discovered a gene in fruit flies that plays a key role in regulating the flow of calcium into cells. Mutations in this gene suppress the effects of degeneration caused by overactive calcium channels, potentially leading to new treatments for diseases like Alzheimer's.
Researchers found that patients who received the gene therapy had less than half of the failures of those without the treatment, with improved vein wall adaptation and reduced blockage rates. The study suggests a new treatment approach to vastly improve bypass surgery success rates.
Researchers have successfully engineered CD4+ T cells to carry a fluorescent marker, allowing for the first time the tracking of autoimmune cells in vivo. The technique enables the study of physiological processes and inflammatory diseases, opening new avenues for therapeutic approaches.
Researchers at the University of Wisconsin-Madison have identified key genes that govern critical biological tasks, revealing how a low-calorie diet slows aging. The study provides insight into the genetic basis of aging and holds promise for developing age-retarding drugs.
Researchers find limited flow of male genes between subpopulations in India due to historically prevalent marriage system. However, they observe certain trends of haplotype sharing between upper and lower castes, suggesting rare conduits for male genes across social ranks.
Researchers have pinpointed an enzyme that controls the shape of a developing organ in the roundworm C. elegans, opening up new avenues for understanding organ development and potentially cancer research. The discovery reveals that two activities work together to define the shape of an organ.
A detailed map of the human genome will require locating at least half a million genetic markers to be useful for pharmaceutical research and development. According to Dr. Leonid Kruglyak, researchers need to locate more genetic markers to stay on track when chasing down genes that influence disease susceptibility and drug response.
Researchers at NICHD discovered a gene, Lhx5, that controls the development of the hippocampus, a brain structure critical for learning and memory. The gene's inactivation leads to a malformed brain structure, highlighting its importance in complex brain function.
A new human gene has been identified as potentially playing a key role in regulating high-density lipoprotein (HDL) levels in the body. The gene's overexpression in mice led to nearly undetectable HDL levels, a condition associated with high cardiovascular disease risk.
A new study reveals that a specific gene variant can make African Americans more sensitive to salt, increasing their risk of developing high blood pressure. The researchers found that even small amounts of salt can raise blood pressure in individuals with the gene variant.
A Johns Hopkins-led study shows that many heart disease features are better explained by the body's responses to genetic damage rather than the damage itself. The research used a miniaturized catheter to compare healthy and diseased mouse hearts, revealing evolving adaptations that worsen symptoms over time.
Researchers at Harvard Medical School have identified a key pathway linking the growth cone's membrane receptor to actin, the final agent of change. The study reveals an uninterrupted chain of signaling events that enables neurons to transmit information from the membrane to the cytoskeleton.
Researchers have identified two genes crucial for auxin transport, a process vital for plant growth and development. The discovery sheds new light on how plants regulate growth and has significant implications for the agrochemical/biotechnology industries.
Researchers found a genetic variation that increases collagenase production, potentially facilitating cancer invasion and spread. This discovery offers clues to molecular switches controlling cancer progression and provides tools for detection and treatment.
Researchers at the University of Chicago have discovered a gene that causes male progeny of two recently separated species to be sterile, hinting at an early indicator of speciation. The homeobox gene is evolving rapidly due to its role in controlling male sexual function, leading to sibling species incompatibility.
A recent DNA study by Alan R. Templeton reveals that the genetic variation among humans is primarily individual-level, with most differences too small to define distinct racial lines. The research challenges the notion of human races as a scientifically valid concept.
A study linked three specific genes to the progress of Long QT syndrome, a heart-rhythm disorder that affects 25,000 Americans annually. Patients with defective genes can now expect their disease course, allowing for targeted treatments and improved outcomes.
Researcher Joy Bergelson finds that genetically engineered plants can outcross with wild relatives at a higher rate than previously thought, potentially leading to the creation of super-weeds. This could lead to increased pesticide use and crop competition for water and nutrients.
Researchers have identified a genetic link between the stargazer gene and calcium channel defects in absence epilepsy. The Cacng2 gene produces a defective protein that disrupts normal brain function, leading to abnormal neuron firing and seizures.
Researchers discovered a new gene called double-time that regulates circadian rhythms in fruit flies, which may also influence human sleep patterns. The gene affects the pairing of proteins essential for maintaining daily cycles.
Researchers discovered a gene linked to hydrocephalus and glaucoma in mice, which is also associated with other birth defects. The gene, called mouse forkhead 1 (mf1), produces an incomplete protein that can cause abnormalities in the brain, eyes, and kidneys.
Researchers at Duke University Medical Center have shown that a new type of gene therapy can correct the defect in human blood cells, potentially providing a treatment for sickle cell anemia. The therapy uses ribozymes to edit defective RNA and could lead to a significant reduction in disease symptoms.
Researchers at Purdue University have identified a genetic link to the aggressive stinging behavior in Africanized honey bees. By mapping genes associated with aggression, they hope to develop markers for selective breeding of gentle bees, which could improve pollination and reduce threats to beekeepers.
Research found genetic make-up plays a significant role in determining individual responses to cholesterol-lowering drugs like Lovastatin. A gene variant associated with unresponsiveness was identified, suggesting that 1 in 12 individuals may not benefit from the treatment.
A team of researchers has identified a defective gene, DFNA15, that causes progressive hearing loss in an Israeli family. The gene was pinpointed using a mouse model and is crucial for normal development of mouse hearing.
Researchers at Harvard Medical School have identified four human genes critical to cell division, which could lead to more effective cancer treatments. The genes are part of the anaphase-promoting complex (APC) and play a crucial role in regulating mitosis.
Researchers at the University of Colorado Boulder have created transgenic mice with gene mutations for hypertrophic cardiomyopathy, a genetic disease that thickens the heart muscle and obstructs blood flow. The study may lead to new therapeutic agents to improve heart function in humans.
Researchers identified a novel gene, Doublecortin, involved in cortical development and associated with severe forms of epilepsy and mental retardation. The gene is linked to the X-SCLH/LIS syndrome, which affects brain structure and function.
A study by Cornell University Medical College researchers suggests that atherosclerosis and some forms of cancer may be linked to a single-cell mutation in the Type II TGF-beta receptor gene. This finding could provide new avenues for understanding cardiovascular disease progression and developing diagnostic and therapeutic strategies.
A landmark study found a unique interaction between proteins produced by two brain genes, mdab1 and reelin, crucial for normal brain development. The discovery may lead to breakthroughs in cancer research and treatments for neurological disorders like schizophrenia and epilepsy.
Researchers have identified the TSC2 gene as the second gene responsible for tuberous sclerosis complex (TSC), a genetic disorder affecting 1 million people worldwide. The discovery of this gene brings hope for diagnostic testing, therapies, and improved understanding of autism and seizure disorders.
Scientists at NIH have identified a gene alteration associated with NPC, leading to improved diagnosis and understanding of the disease. The finding also offers insights into cholesterol metabolism and may contribute to treatments for atherosclerosis.
A novel mechanism has been initiated at UC Davis to pool university and industry resources, compensating nations for valuable genetic material. The Genetic Resources Recognition Fund will finance graduate fellowships for students from countries that originally provided the genetic material.
Researchers identified a chromosome 8 gene linked to human epilepsy and migraines, also affecting mice with similar traits. The study suggests a potential cure or prevention method for these diseases.
Researchers at Johns Hopkins Medicine identify TWIST gene as cause of Saethre-Chotzen syndrome, a rare genetic disorder characterized by craniofacial abnormalities and limb defects. The study confirms the role of the TWIST protein in human development and provides insight into the confusion with Crouzon syndrome.
Researchers found that social behavior dictates genetic flow within a single species of social insects, challenging traditional theories. The study discovered four routes of gene flow between single-queen and multiple-queen colonies, highlighting the role of queens in shaping gene exchange.
A team of researchers has found that most DNA mutations in yeast are caused by the activity of an enzyme called REV1. The enzyme helps cells evade quality control and can produce mutations when repairing damaged DNA, potentially leading to cancer.