Articles tagged with Genetic Regulatory Circuits
A research team has developed a 'SUPER' platform that utilizes synthetic small RNAs as add-on controllers for genetic switches. This technology enhances the performance and stability of gene regulatory devices by addressing the issue of 'leakage', where genes continue to express at low levels even in the 'OFF' state.
Researchers link neuropilin2 gene to autism and seizure development, highlighting its role in regulating neural circuits. The study suggests targeting specific phases of neuronal development could lead to therapeutic interventions for individuals with autism.
The team developed a Synthetic Translational Coupling Element (SynTCE) that enhances the precision and integration density of genetic circuits in synthetic biology. This allows for more efficient gene circuit integration, minimizing interference between biological parts and enabling precise control over multiple genes.
Researchers at MUSC discover an RNA:DNA 'sandwich' plays a key role in how the brain interprets emotional experiences and brings about behavioral adaptations. The discovery could lead to better RNA therapies for treating brain disorders.
Researchers have developed a smart RNA capable of regulating gene expression in response to various signals, enabling the precise design of gene therapies and advanced personalized treatments for diseases.
A UCLA Health study has unveiled the link between genetic risk of autism and observed cellular activity in the brain. Researchers analyzed post-mortem brain tissue from 66 individuals, including those with autism spectrum disorder, to identify changes in cortical cell types and transcription factor networks.
Researchers mapped the evolution of a specific regulatory protein over millennia, revealing a novel pattern where function gain and loss occur rapidly. This study may reveal similar patterns in other regulatory proteins, enabling new discoveries in biomedical and biotechnological applications.
Researchers have engineered a synthetic gene oscillator device that slows down the aging process in yeast cells by cycling deterioration between two detrimental states. This approach resulted in an 82% increase in lifespan compared to control cells, setting a new record for life extension through genetic and chemical interventions.
Researchers identify genetic circuit that senses cell development stage, triggering deactivation of X chromosome. The discovery reveals a division of labor among genetic switches, providing clues for future study on X chromosome inactivation.
Coffman's research will investigate the role of Klf9 in regulating stress response system using zebrafish as a model, with implications for understanding chronic disease and developing novel therapies. The grant aims to elucidate pathways governing stress response and create tools for future research.
A study by University of Oulu researchers has identified novel genes and mechanisms associated with aggressive prostate cancer progression. The research suggests ways to improve risk stratification and clinical treatment for advanced prostate cancer.
Neuroscientists at the University of Nevada, Reno identified a genetic mechanism in fruit flies that disrupts brain pathways connecting the left and right hemispheres, separately linked to autism. The study suggests that the human gene PRRG4 may play a role in regulating nerve fiber guidance and synapse formation.
Researchers mapped the molecular pathways and signaling circuits of CD8+ T cells responding to infections and cancer. They identified novel biological pathways and discovered highly dynamic processes as these cells develop. The study aims to help advance vaccine development and cancer immunotherapy.
Researchers at MIT have programmed cells to remember and respond to a series of events, including substances commonly used in lab experiments. This approach enables the creation of environmental sensors that store complex histories and biological state machines with different behaviors.
Researchers at the Wyss Institute have developed synthetic gene controls that can be used to create programmable diagnostics and biosensors, which can detect specific diseases or infections using saliva or a drop of blood. The new tools are delivered on pocket-sized slips of paper, making them portable and accessible for widespread use.
Researchers at ETH Zurich have developed an implantable genetic circuit that monitors and regulates blood fat levels, reducing hunger and promoting weight loss in obese mice. The innovative device exploits the natural human satiety mechanism, providing a potential alternative to surgical interventions.
A study published in Science reveals that genetic changes associated with diseases impact the genome's regulatory circuitry, affecting gene expression rather than genes themselves. The research exposed previously hidden connections between different diseases and offers a new approach for pinpointing specific cell types involved in dise...
A large-scale study has reconstructed a key molecular circuit in mammalian immune cells, identifying over 100 regulators that work together to distinguish viruses from bacteria. The research provides a deeper understanding of immune biology and could inspire novel ways to treat disease and design better vaccines.
Researchers have made new inroads into understanding the regulatory circuitry of the biological clock that synchronizes daily activities. Two studies published in Cell and Molecular Cell provide a complete view of the regulation of circadian clocks across a day, revealing the role of phosphorylation and temperature compensation.
Researchers discovered how microRNAs fit into the map of embryonic stem cell circuitry, providing clues for targeting specific microRNAs to direct an embryonic stem cell into another type of cell. The study also provides a better platform for analyzing microRNA gene expression in cancer and other diseases.
Research suggests that a specific gene variant linked to aggression impairs the brain's ability to regulate impulses and emotions, particularly in males. This impairment can lead to increased reactivity in the fear hub and reduced activity in higher brain areas that regulate emotional responses.