Articles tagged with Homologous Chromosomes
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Researchers found correlations between MIF and DDT levels with patient survival outcomes in melanoma patients. Higher CD74:MIF and CD74:DDT levels were associated with improved survival and enrichment of inflammatory markers.
A team of scientists at Pohang University of Science & Technology uncovered the molecular mechanism responsible for crossover interference during meiosis, a biological process that generates genetically diverse reproductive cells. The findings have significant implications for breeding and cultivating crops with specific desired traits.
Researchers have developed a novel tool for the selective and efficient recovery of large DNA molecules using TAR cloning. This technique has been applied to isolate individual gene alleles, study genome architecture and evolution, and engineer synthetic viruses with novel properties, including vaccine development.
Researchers discovered a trio of protein segments guiding chromosomal interactions in nematodes, shedding light on the complex process. The study, published in PNAS, provides new insights into meiosis and infertility, with implications for human reproductive health.
Researchers from Northwestern University discuss the multifaceted tumorigenic functions of EZH2, including its role in regulating translation and coactivating transcription. This new understanding may provide novel insights into advancing EZH2-targeting strategies for prostate cancer patients.
Researchers have identified a new gene, NUCL-1, in the transparent roundworm C. elegans, which is linked to human neurodegenerative diseases such as ALS and Alzheimer's. The discovery challenges recent theories on the role of nuclear structures in these disorders.
Researchers found evidence supporting a new theory on how chromosome recombination is regulated during sexual reproduction. By manipulating protein expressions in the model plant Arabidopsis thaliana, they discovered that boosting HEI10 levels significantly increased crossovers, while disrupting ZYP1 expression had a similar effect.
Researchers at Johns Hopkins Medicine discovered a peptide on the SARS-CoV-2 spike protein that triggers an immune response in humans and is also recognized by cells of the immune system, suggesting potential for protection against future zoonotic outbreaks. The study supports the development of multivalent vaccines against a broad spe...
Researchers at Kumamoto University have clarified the mechanism behind homologous chromosome pairing, a process necessary for sperm and egg formation. The study shows that cohesin acts as a marker to call HORMAD1 to the chromosome prior to homologous chromosome pairing, highlighting its importance in reproductive medicine.
The study found that the common ancestor of Deinococcus species was rod-shaped, with six conserved genes (MreB, MreC, MreD, MrdA, RodA, and RodZ) present in all rod-shaped species. Phylogenetic analysis revealed that major gene loss occurred four times during evolution, generating spherical shape species.
Researchers at EPFL create cellular and mouse models that accurately reproduce the evolution of Parkinson's disease, using insights into protein clumps called Lewy bodies. The new models can propel research and drug development, offering a powerful tool for rapid screening of molecular pathways involved in the disease.
Researchers at Washington University in St. Louis have identified seven genes encoding mechanosensitive channels in Arabidopsis thaliana, a small flowering plant related to mustard and cabbage. These channels are believed to play a crucial role in plant movement and response to physical stimuli.
Researchers at UNC Health Care discovered the Kaposi sarcoma virus produces a homolog protein that binds to cellular proteins, preventing inflammatory response and allowing the virus to evade immune system detection. The study highlights the virus's ability to lie dormant in the body over a lifetime by avoiding cell death.
Researchers at UC Berkeley discover that the cytoskeleton plays a critical role in pairing and recombining chromosomes during meiosis. By forming bridges between chromosomes and patches on the nuclear membrane, the cytoskeleton helps ensure homologous chromosome pairing, a crucial step in sex cells' development.
A groundbreaking study published in the Journal of Cell Biology reveals that the protein Pds5 plays a vital regulatory role during meiosis, failing to segregate and pair up properly when it is absent. This finding has significant implications for understanding human chromosomal birth defects, including Down syndrome.
The study identifies a cluster of essential genes on mouse chromosome 11 that are highly conserved across species, including humans. This finding suggests that there may be rules governing the structure and organization of chromosomes.
A team of biologists at UC Berkeley has found a key gene involved in the first step of meiosis, allowing chromosomes to recognize and pair with their homologs. This discovery is crucial for understanding meiosis in humans and could lead to insights into infertility and genetic diseases.
Mouse cells lacking nonhomologous DNA end-joining (NHEJ) pathway show high levels of chromosome breakage and genetic material rearrangement, highlighting its critical role in maintaining genomic stability. The study also reveals that NHEJ is essential for repairing damaged chromosomes induced by ionizing radiation.