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Scientists report first transgenic animal developed via retroviral DNA insertion into male germ-line stem cells

Researchers at University of Pennsylvania successfully inserted a foreign gene into male mouse spermatogonial stem cells, achieving high efficiency and expression. The breakthrough enables the creation of transgenic individuals in various species, paving the way for studying human diseases.

SourceUniversity of Pennsylvania·JournalProceedings of the National Academy of Sciences·DateOct 22, 2001