A molecule that binds toll-like receptors doubles the early antibody response to an antigen and shifts it to a more effective IgG form. The findings support bridge immunity, which links innate and adaptive arms of the immune response.
Researchers at Duke University Medical Center discovered that the cytokine interleukin-17 plays a significant role in disc disease and may lead to the development of new therapeutic approaches. Targeting this immune response could reduce painful inflammation and halt the evolution of arthritis.
Natural killer cells help maintain a balance between T cells and the immune system, preventing over-response that can cause harm. Understanding how to keep NK cells around could lead to new treatments for patients with compromised immune systems.
A new mouse model reveals that innate immunity plays a key role in driving symptoms of auto-inflammatory diseases. The study shows that the innate immune system is responsible for the over-activation leading to inflammation and symptoms.
Scientists at Mayo Clinic and VBI aim to understand how environmental fungus Alternaria triggers airway inflammation and bronchial asthma. They plan to develop specific therapies and prevention strategies by studying the role of fungal enzymes in innate immune responses.
Researchers challenge traditional hypotheses on Crohn's disease, suggesting a more complex role for cytokines in the immune response. This could lead to new treatment strategies involving the blockade of multiple cytokines.
A new study suggests that using stents to open blocked blood vessels in branching passages can lead to a harmful blood flow pattern, resulting in rapid re-occlusion of the main branch. This contradicts previous findings that suggest stenting was more successful in non-bifurcated areas.
GammaDelta T cells are activated by bacterial pathogens, recognizing and responding to peptidoglycan patterns. They release pro-inflammatory cytokines to coordinate an immune response, providing innate protection against bacterial infections.