Breaking down the walls of immunological ignorance
The study reveals key mechanisms and pathways involved in immune response regulation. It highlights the importance of understanding immunological functions to develop new therapeutic approaches.
Antigens
Articles tagged with Antigens
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Viral proteins may be associated with human brain tumors, according to findings by Temple researchers
Researchers found viral genome and proteins T antigen and agnoprotein in pediatric brain tumor samples, suggesting a potential role in tumor development. The discovery of agnoprotein expression in the absence of T-antigen expression suggests a possible pathway for tumor growth.
Viral protein may be associated with human brain tumors
Studies found that agnoprotein and T antigen are present in 45% of medulloblastoma samples, with some containing only agnoprotein. The presence of these proteins suggests a potential link between the JC virus and brain tumor development.
Researchers identify a key 'brake' of the immune response
Scientists have identified ILT3 and ILT4, a key pair of molecules that function as a brake for the immune response. Increasing their activity on dendritic cells may create tolerance to foreign tissues, while decreasing it can enhance the immune response against malignant cells.
Cyclin B1 identified as a new tumor antigen and candidate for the development of a cancer vaccine
Researchers at the University of Pittsburgh Medical Center have identified cyclin B1 as a promising new tumor antigen for cancer vaccine development. The study found that cyclin B1 is over-expressed in breast and lung cancer cells, making it an attractive target for immunotherapy.
New DNA-base vaccine approach protects mice against anthrax
Researchers at Ohio State University have developed a new DNA-based vaccine approach that successfully immunizes mice against anthrax. The vaccine uses combinations of two gene products produced by the bacteria responsible for causing anthrax, resulting in strong immune responses.
DNA vaccination places tumors in double jeopardy
A new DNA-based cancer treatment has shown promise by targeting and eliminating tumor cells. Researchers have discovered that DNA vaccination can place tumors in a state of immune activation, making them more susceptible to attack.
A match for life
The Office of Naval Research developed an inexpensive and effective HLA test to screen potential bone marrow donors, increasing compatibility by 30%. New research aims to slow down tissue rejection response, allowing near matches.
TB research foundation announces vaccine grants
The Sequella Global Tuberculosis Foundation has awarded $500,000 in grants to nine researchers working on innovative tuberculosis vaccines. The grants will fund projects using novel adjuvants, delivery mechanisms, and immunological approaches.
Dendreon identifies novel approach to improve immunization efficiency
Researchers at Dendreon Corporation have developed a method for generating enhanced immune responses with potentially important implications for therapeutic cancer vaccines. The approach involves modifying antigens to optimize uptake and processing by dendritic cells, resulting in significant cytotoxic T-cell activity.
First potential 'universal' cancer vaccine shows promise in lab
Researchers at Duke University Medical Center and Geron Corp. have made promising findings on a 'universal' cancer vaccine based on the telomerase protein. The active part of telomerase can stimulate development of immune cells that recognize and kill multiple, unrelated mouse and human cancer cells.
Life and death struggle: Proteins play against each other, bringing balance to immune system
Researchers at National Jewish Health discovered how proteins IL-15 and IL-2 work together to control the immune response against viruses. The proteins balance the production and division of memory killer T cells, allowing the immune system to battle antigens with a controlled response.
Jellyfish protein illuminates active immune cells
Using genetically manipulated T cells producing a fluorescent jellyfish protein, researchers observed the movement of MEKK2 towards T cell receptors within seconds of antigen binding. This study reveals MEKK2's crucial role in delivering molecular signals to the nucleus and active attachment between immune cells.
Scientists visualize key molecular interactions that activate the immune response to foreign proteins
Researchers used imaging to 'movie' the interaction between a T cell and an antigen-presenting cell, revealing specific protein rearrangements that form an immunological synapse. This structure determines whether a T cell will respond to an antigen.
Researchers Discover How The Immune System Shuts Down Faulty T Cells
The study identifies a mechanism by which the immune system eliminates dysfunctional T cells, which can lead to autoimmune diseases and cancer. The research suggests that continuous contact with class I MHC proteins is essential for maintaining the balance between cell survival and death.
Researcher Awarded Patent For System To Fight Multiple Diseases
Roy Curtiss III's patent covers a genetically engineered bacterial antigen delivery system that induces immune responses against foreign antigens. The technology is being used to develop recombinant vaccines for various pathogens, including Heliobacter pylori and Mycobacterium tuberculosis.
Security Code Helps Immune Cells Attack Foe And Spare Self
Researchers discovered a specific code that unlocks T cell activation, preventing immune cells from attacking the body's own cells. The code is: B1, C2, A1, A2, B2, C1.
Wistar Research Yields Information About Colorectal Cancer Cell Invasion
Researchers at The Wistar Institute have identified a key role for the GA733 antigen in inhibiting colorectal cancer cell invasion. The discovery has led to the development of an antibody that increases survival rates for CRC patients.
RNA-Dendritic Cell Combo Shows Promise As A Universal Cancer Vaccine
Researchers at Duke University Medical Center have developed a novel vaccine that uses RNA and dendritic cells to target cancer cells. The vaccine stimulates an immediate and sustained assault on human cells in test tube experiments, showing promise as a universal cancer vaccine.
Researchers From Rockefeller University Develop Novel Method To Fight Cancer
Researchers from Rockefeller University have developed a new method to fight cancer by using dendritic cells to activate T cells. This technique offers the promise of new therapies for cancer, AIDS, and autoimmune diseases, potentially overcoming the need for designer immunotherapy.
Cancer Immunotherapy - Supplying The Wake Up Call
Researchers are developing a new approach to cancer treatment called adoptive immunotherapy, which uses tumour antigens to stimulate immune cells. Tumour antigens are identified and used to sensitize T cells, which then recognize and attack cancer cells.
Magnetic Attraction: Towards A New Era In Treating Rh-Factor Incompatibility
A new technology has been developed to address the need for Rh immune globulin, a treatment for pregnant women with Rh-Factor Incompatibility. The approach uses phage display to isolate anti-Rh antibodies from whole cells, offering a promising solution to this long-standing problem.
New Procedure Speeds Detection of Livestock Parasite
A new diagnostic test uses purified proteins to detect Neospora caninum, a parasite causing cattle abortions. The test has been developed by the US Department of Agriculture and is expected to be commercially available within two to three years.