Articles tagged with Autoimmune Disorders
Researchers at Wyeth determined the three-dimensional structure of PKCΘ, a key signaling molecule in T lymphocytes. This discovery has potential to identify selective inhibitors for autoimmune diseases by disabling T cell activation.
A Mayo Clinic study found that most children with juvenile dermatomyositis (JDM) carry a particular gene from their mother, triggering an immune response. The research suggests that maternal cells may play a role in the development of JDM, a rare condition that causes inflammation and muscle damage.
Activation of antigen-presenting cells (APCs) by microbial products leads to the breakdown of self-tolerance in the immune system. This breakdown induces autoimmune disease, a condition where the immune system mistakenly attacks healthy tissues.
Researchers at UCSD identified a key gene pathway contributing to pulmonary hypertension, with potential molecular targets for new therapies. The study revealed that abnormal expression of angiopoietin-1 leads to muscle cell proliferation in lung vessels, causing disease progression.
Scientists are developing an encyclopedia of innate immune system activity using systems biology approaches. This could lead to a better understanding of inflammation and its control, potentially revealing targets for new drugs. The study also explores the use of bioinformatics resources to support research on immune-mediated diseases.